Aliases for NXT1 Gene
External Ids for NXT1 Gene
Previous GeneCards Identifiers for NXT1 Gene
The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for NXT1 Gene
NXT1 (Nuclear Transport Factor 2 Like Export Factor 1) is a Protein Coding gene. Diseases associated with NXT1 include St. Louis Encephalitis. Among its related pathways are RNA transport and Transport of Mature Transcript to Cytoplasm. Gene Ontology (GO) annotations related to this gene include Ran GTPase binding. An important paralog of this gene is NXT2.
UniProtKB/Swiss-Prot for NXT1 Gene
Stimulator of protein export for NES-containing proteins (PubMed:10567585). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:19165146, PubMed:11259602).