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Aliases for MRPL22 Gene

Aliases for MRPL22 Gene

  • Mitochondrial Ribosomal Protein L22 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein UL22m 3 4
  • 39S Ribosomal Protein L25, Mitochondrial 3 4
  • MRP-L22 3 4
  • MRP-L25 3 4
  • RPML25 3 4
  • L22mt 3 4
  • L25mt 3 4
  • 39S Ribosomal Protein L22, Mitochondrial 3
  • HSPC158 3
  • MRPL25 4

External Ids for MRPL22 Gene

Previous GeneCards Identifiers for MRPL22 Gene

  • GC05P154413
  • GC05P154303
  • GC05P154349
  • GC05P154300
  • GC05P149462

Summaries for MRPL22 Gene

Entrez Gene Summary for MRPL22 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL22 Gene

MRPL22 (Mitochondrial Ribosomal Protein L22) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL22 Gene

Additional gene information for MRPL22 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL22 Gene

Genomics for MRPL22 Gene

GeneHancer (GH) Regulatory Elements for MRPL22 Gene

Promoters and enhancers for MRPL22 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J154940 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.5 497 2.3 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF143 SP3 MRPL22 KIF4B CNOT8 GC05P154943
GH05J154962 Enhancer 0.6 ENCODE 11.3 +21.6 21606 0.2 PKNOX1 JUN JUNB MEF2B BATF ATF2 FOS PRDM1 RUNX3 SPI1 GEMIN5 MRPL22 KIF4B GC05P154943 LOC100288010
GH05J154583 Enhancer 1.1 FANTOM5 ENCODE 1.5 -356.4 -356428 2 NEUROD1 KLF17 ELK1 ZNF366 RCOR1 FOS DEK SMARCC1 CEBPB GATAD2B HAND1 SAP30L-AS1 MRPL22 SAP30L MIR3141 CIR1P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPL22 gene promoter:
  • AP-1
  • Cdc5
  • NRSF form 2
  • NRSF form 1
  • NF-1
  • Hand1
  • E47
  • Sox5
  • FAC1
  • Evi-1

Genomic Locations for MRPL22 Gene

Genomic Locations for MRPL22 Gene
28,342 bases
Plus strand
28,342 bases
Plus strand

Genomic View for MRPL22 Gene

Genes around MRPL22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL22 Gene

Proteins for MRPL22 Gene

  • Protein details for MRPL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L22, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6NGJ8
    • Q5H9Q1
    • Q96Q51
    • Q9P006

    Protein attributes for MRPL22 Gene

    206 amino acids
    Molecular mass:
    23641 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    • Sequence=AAF29122.1; Type=Frameshift; Positions=197; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL22 Gene

    Alternative splice isoforms for MRPL22 Gene


neXtProt entry for MRPL22 Gene

Post-translational modifications for MRPL22 Gene

  • Ubiquitination at Lys191
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL22 Gene

No data available for DME Specific Peptides for MRPL22 Gene

Domains & Families for MRPL22 Gene

Gene Families for MRPL22 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Ribosomal proteins

Protein Domains for MRPL22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL22 family.
  • Belongs to the universal ribosomal protein uL22 family.
genes like me logo Genes that share domains with MRPL22: view

Function for MRPL22 Gene

Phenotypes From GWAS Catalog for MRPL22 Gene

Gene Ontology (GO) - Molecular Function for MRPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003735 structural constituent of ribosome IEA,IBA --
genes like me logo Genes that share ontologies with MRPL22: view
genes like me logo Genes that share phenotypes with MRPL22: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL22 Gene

Localization for MRPL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL22 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL22 gene
Compartment Confidence
mitochondrion 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
GO:0015934 large ribosomal subunit IEA --
genes like me logo Genes that share ontologies with MRPL22: view

Pathways & Interactions for MRPL22 Gene

genes like me logo Genes that share pathways with MRPL22: view

Gene Ontology (GO) - Biological Process for MRPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL22: view

No data available for SIGNOR curated interactions for MRPL22 Gene

Drugs & Compounds for MRPL22 Gene

No Compound Related Data Available

Transcripts for MRPL22 Gene

mRNA/cDNA for MRPL22 Gene

Unigene Clusters for MRPL22 Gene

Mitochondrial ribosomal protein L22:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL22 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for MRPL22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL22 Gene

Protein differential expression in normal tissues from HIPED for MRPL22 Gene

This gene is overexpressed in Lung (31.2) and Pancreas (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL22 Gene

Protein tissue co-expression partners for MRPL22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL22 Gene:


SOURCE GeneReport for Unigene cluster for MRPL22 Gene:


Evidence on tissue expression from TISSUES for MRPL22 Gene

  • Skin(4.2)
  • Blood(4.1)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with MRPL22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL22 Gene

Orthologs for MRPL22 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPL22 34 33
  • 99.51 (n)
(Bos Taurus)
Mammalia MRPL22 34 33
  • 91.18 (n)
(Canis familiaris)
Mammalia MRPL22 34 33
  • 90.36 (n)
(Mus musculus)
Mammalia Mrpl22 16 34 33
  • 85.76 (n)
(Rattus norvegicus)
Mammalia Mrpl22 33
  • 85.6 (n)
(Monodelphis domestica)
Mammalia MRPL22 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL22 34
  • 78 (a)
(Gallus gallus)
Aves MRPL22 34 33
  • 72.59 (n)
(Anolis carolinensis)
Reptilia MRPL22 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl22 33
  • 67.67 (n)
Str.17424 33
(Danio rerio)
Actinopterygii mrpl22 34 33
  • 71.46 (n)
Dr.13982 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12520 33
fruit fly
(Drosophila melanogaster)
Insecta mRpL22 34 33
  • 55.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000508 33
  • 51.63 (n)
(Caenorhabditis elegans)
Secernentea mrpl-22 34 33
  • 45.27 (n)
Species where no ortholog for MRPL22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL22 Gene

Gene Tree for MRPL22 (if available)
Gene Tree for MRPL22 (if available)
Evolutionary constrained regions (ECRs) for MRPL22: view image

Paralogs for MRPL22 Gene Pseudogenes for MRPL22 Gene

genes like me logo Genes that share paralogs with MRPL22: view

No data available for Paralogs for MRPL22 Gene

Variants for MRPL22 Gene

Sequence variations from dbSNP and Humsavar for MRPL22 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000030775 -- 154,947,487(+) A/G intron_variant
rs1000072418 -- 154,940,356(+) T/G upstream_transcript_variant
rs1000128735 -- 154,947,368(+) G/A intron_variant
rs1000199325 -- 154,945,776(+) A/G intron_variant
rs1000267219 -- 154,965,693(+) A/G/T intron_variant

Variation tolerance for MRPL22 Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL22 Gene

Disorders for MRPL22 Gene

Additional Disease Information for MRPL22

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPL22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL22 Gene

Publications for MRPL22 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MRPL22 Gene

Sources for MRPL22 Gene

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