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Aliases for MRPL15 Gene

Aliases for MRPL15 Gene

  • Mitochondrial Ribosomal Protein L15 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein UL15m 3 4
  • MRP-L15 3 4
  • L15mt 3 4
  • 39S Ribosomal Protein L15, Mitochondrial 3
  • HSPC145 3
  • MRP-L7 3
  • RPML7 3

External Ids for MRPL15 Gene

Previous GeneCards Identifiers for MRPL15 Gene

  • GC08P054319
  • GC08P054987
  • GC08P054770
  • GC08P055097
  • GC08P055210
  • GC08P050515

Summaries for MRPL15 Gene

Entrez Gene Summary for MRPL15 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL15 Gene

MRPL15 (Mitochondrial Ribosomal Protein L15) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL15 Gene

Additional gene information for MRPL15 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL15 Gene

Genomics for MRPL15 Gene

GeneHancer (GH) Regulatory Elements for MRPL15 Gene

Promoters and enhancers for MRPL15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I054134 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.6 560 3.2 PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 IRF4 MRPL15 TCEA1 RNU6ATAC32P
GH08I054100 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.8 -33.8 -33778 2.7 MLX ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ZNF766 GLIS2 ELK1 ZNF143 LYPLA1 TCEA1 MRPL15 TDGF1P5
GH08I054165 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.5 +30.7 30711 1 HDAC1 CLOCK ATF1 ARID4B SIN3A RAD21 ZNF335 ZNF766 ZNF143 BCLAF1 MRPL15 SOX17 ATP6V1H TCEA1 RNU6ATAC32P GC08M054193
GH08I054105 Enhancer 1 FANTOM5 ENCODE 13.2 -28.7 -28692 1.7 HDAC1 PKNOX1 ZBTB40 FOS NCOA1 USF2 ZEB2 HDAC8 ZNF592 ZNF217 PIR33175 MRPL15 TCEA1 RGS20 ATP6V1H LYPLA1
GH08I054169 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.5 +34.8 34791 1.6 CTCF RB1 GTF2E2 CEBPG RAD21 GTF3C2 POLR2A SMC3 ZNF143 ZNF654 MRPL15 SOX17 ATP6V1H CHCHD2P10 RNU6ATAC32P GC08M054193
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRPL15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPL15 gene promoter:

Genomic Locations for MRPL15 Gene

Genomic Locations for MRPL15 Gene
chr8:54,135,210-54,148,514
(GRCh38/hg38)
Size:
13,305 bases
Orientation:
Plus strand
chr8:55,047,770-55,061,074
(GRCh37/hg19)

Genomic View for MRPL15 Gene

Genes around MRPL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL15 Gene

Proteins for MRPL15 Gene

  • Protein details for MRPL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P015-RM15_HUMAN
    Recommended name:
    39S ribosomal protein L15, mitochondrial
    Protein Accession:
    Q9P015
    Secondary Accessions:
    • Q96Q54
    • Q9H0Y1

    Protein attributes for MRPL15 Gene

    Size:
    296 amino acids
    Molecular mass:
    33420 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL15 Gene

neXtProt entry for MRPL15 Gene

Post-translational modifications for MRPL15 Gene

  • Ubiquitination at isoforms=28 and isoforms=80
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL15 Gene

No data available for DME Specific Peptides for MRPL15 Gene

Domains & Families for MRPL15 Gene

Gene Families for MRPL15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for MRPL15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P015

UniProtKB/Swiss-Prot:

RM15_HUMAN :
  • Belongs to the universal ribosomal protein uL15 family.
Family:
  • Belongs to the universal ribosomal protein uL15 family.
genes like me logo Genes that share domains with MRPL15: view

Function for MRPL15 Gene

Phenotypes From GWAS Catalog for MRPL15 Gene

Gene Ontology (GO) - Molecular Function for MRPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IBA,IEA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with MRPL15: view
genes like me logo Genes that share phenotypes with MRPL15: view

Animal Model Products

miRNA for MRPL15 Gene

miRTarBase miRNAs that target MRPL15

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL15 Gene

Localization for MRPL15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL15 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL15 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for MRPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
GO:0015934 large ribosomal subunit IEA --
genes like me logo Genes that share ontologies with MRPL15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPL15 Gene

Pathways & Interactions for MRPL15 Gene

genes like me logo Genes that share pathways with MRPL15: view

Gene Ontology (GO) - Biological Process for MRPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
GO:1990830 cellular response to leukemia inhibitory factor IEA --
genes like me logo Genes that share ontologies with MRPL15: view

No data available for SIGNOR curated interactions for MRPL15 Gene

Drugs & Compounds for MRPL15 Gene

No Compound Related Data Available

Transcripts for MRPL15 Gene

Unigene Clusters for MRPL15 Gene

Mitochondrial ribosomal protein L15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL15 Gene

No ASD Table

Relevant External Links for MRPL15 Gene

GeneLoc Exon Structure for
MRPL15
ECgene alternative splicing isoforms for
MRPL15

Expression for MRPL15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL15 Gene

mRNA differential expression in normal tissues according to GTEx for MRPL15 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for MRPL15 Gene

This gene is overexpressed in Breast (35.6) and Lung (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL15 Gene



Protein tissue co-expression partners for MRPL15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL15 Gene:

MRPL15

SOURCE GeneReport for Unigene cluster for MRPL15 Gene:

Hs.18349

Evidence on tissue expression from TISSUES for MRPL15 Gene

  • Nervous system(4.6)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with MRPL15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL15 Gene

Orthologs for MRPL15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL15 33 34
  • 99.77 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL15 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL15 33 34
  • 90.54 (n)
mouse
(Mus musculus)
Mammalia Mrpl15 33 16 34
  • 85.76 (n)
cow
(Bos Taurus)
Mammalia MRPL15 33 34
  • 83.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL15 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL15 33 34
  • 74.77 (n)
lizard
(Anolis carolinensis)
Reptilia MRPL15 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl15 33
  • 70.23 (n)
Str.7141 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19285 33
zebrafish
(Danio rerio)
Actinopterygii mrpl15 33 34
  • 65.16 (n)
Dr.18509 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.652 33
fruit fly
(Drosophila melanogaster)
Insecta mRpL15 35 33 34
  • 53.41 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011946 33
  • 52.55 (n)
worm
(Caenorhabditis elegans)
Secernentea mrpl-15 33 34
  • 45.18 (n)
Y92H12BR.8 35
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL10 34 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToOne
Species where no ortholog for MRPL15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL15 Gene

ENSEMBL:
Gene Tree for MRPL15 (if available)
TreeFam:
Gene Tree for MRPL15 (if available)

Paralogs for MRPL15 Gene

Pseudogenes.org Pseudogenes for MRPL15 Gene

genes like me logo Genes that share paralogs with MRPL15: view

No data available for Paralogs for MRPL15 Gene

Variants for MRPL15 Gene

Sequence variations from dbSNP and Humsavar for MRPL15 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000272980 -- 54,146,819(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000347964 -- 54,148,492(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000376196 -- 54,134,601(+) A/G upstream_transcript_variant
rs1000409496 -- 54,141,571(+) G/A intron_variant
rs1000425801 -- 54,141,233(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL15 Gene

Variant ID Type Subtype PubMed ID
nsv1026869 CNV gain 25217958
nsv510147 OTHER sequence alteration 20534489
nsv820132 CNV gain 19587683

Variation tolerance for MRPL15 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL15 Gene

Disorders for MRPL15 Gene

Additional Disease Information for MRPL15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPL15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL15 Gene

Publications for MRPL15 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 2 3 4 58
  2. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58

Products for MRPL15 Gene

Sources for MRPL15 Gene

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