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Aliases for GRINA Gene

Aliases for GRINA Gene

  • Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1 2 3 5
  • Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate-Associated Protein 1 (Glutamate Binding) 2 3
  • Transmembrane BAX Inhibitor Motif-Containing Protein 3 3 4
  • Glutamate [NMDA] Receptor-Associated Protein 1 3 4
  • Transmembrane BAX Inhibitor Motif Containing 3 2 3
  • NMDA Receptor Glutamate-Binding Subunit 3 4
  • Putative MAPK-Activating Protein PM02 3 4
  • NMDARA1 3 4
  • TMBIM3 3 4
  • LFG1 3 4
  • Glutamate Receptor, NMDA Subtype, Glutamate-Binding Subunit 3
  • Protein Lifeguard 1 3
  • HNRGW 3

External Ids for GRINA Gene

Previous HGNC Symbols for GRINA Gene


Previous GeneCards Identifiers for GRINA Gene

  • GC08U990038
  • GC08M145371
  • GC08P144839
  • GC08P145170
  • GC08P145171
  • GC08P145136
  • GC08P145064
  • GC08P140305

Summaries for GRINA Gene

GeneCards Summary for GRINA Gene

GRINA (Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1) is a Protein Coding gene. Among its related pathways are nNOS Signaling at Neuronal Synapses and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include ion channel binding. An important paralog of this gene is FAIM2.

UniProtKB/Swiss-Prot for GRINA Gene

  • Potential apoptotic regulator.

Additional gene information for GRINA Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRINA Gene

Genomics for GRINA Gene

GeneHancer (GH) Regulatory Elements for GRINA Gene

Promoters and enhancers for GRINA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J143989 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 +0.3 333 2.3 ARID4B SIN3A ZNF48 ZNF207 SP3 SP5 GMEB1 NR2C1 HNF4A WT1 GRINA PLEC ENSG00000254973 SPATC1 PARP10
GH08J143991 Enhancer 0.2 ENCODE 650.7 +1.7 1670 0.2 GRINA SPATC1 PARP10
GH08J143914 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.1 -52.9 -52928 45.2 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 MEF2D PLEC EEF1D ZNF7 MAF1 RPL8 ZNF251 GPAA1 CPSF1 ZNF623 SHARPIN
GH08J143430 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 5.1 -559.0 -558976 1.6 PKNOX1 ARID4B SIN3A ZNF2 ETS1 GLIS2 CBX5 ZNF207 ZNF143 ATF7 MAFA ZNF623 JRK VPS28 CPSF1 LOC105375798 GSDMD ZNF696 GRINA PIR44330
GH08J144011 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 3.9 +22.5 22479 2.3 HDGF EBF1 RELA FOSL1 ZNF316 POLR2A EED ATF7 ETV6 IKZF2 SPATC1 PARP10 PLEC ENSG00000255224 GRINA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRINA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRINA gene promoter:
  • Max1
  • c-Myc
  • MyoD

Genomic Locations for GRINA Gene

Genomic Locations for GRINA Gene
3,362 bases
Plus strand
3,358 bases
Plus strand

Genomic View for GRINA Gene

Genes around GRINA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRINA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRINA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRINA Gene

Proteins for GRINA Gene

  • Protein details for GRINA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein lifeguard 1
    Protein Accession:
    Secondary Accessions:
    • B3KXM7
    • O43836
    • Q8IVW7

    Protein attributes for GRINA Gene

    371 amino acids
    Molecular mass:
    41203 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB94292.1; Type=Frameshift; Positions=224, 371; Evidence={ECO:0000305};

neXtProt entry for GRINA Gene

Post-translational modifications for GRINA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRINA Gene

Domains & Families for GRINA Gene

Gene Families for GRINA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GRINA Gene


Suggested Antigen Peptide Sequences for GRINA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BI1 family. LFG subfamily.
  • Belongs to the BI1 family. LFG subfamily.
genes like me logo Genes that share domains with GRINA: view

Function for GRINA Gene

Molecular function for GRINA Gene

UniProtKB/Swiss-Prot Function:
Potential apoptotic regulator.
GENATLAS Biochemistry:
N-methyl D-aspartate receptor,glutamate receptor,glutamate binding subunit

Phenotypes From GWAS Catalog for GRINA Gene

Gene Ontology (GO) - Molecular Function for GRINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044325 ion channel binding IEA --
genes like me logo Genes that share ontologies with GRINA: view
genes like me logo Genes that share phenotypes with GRINA: view

Animal Models for GRINA Gene

MGI Knock Outs for GRINA:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRINA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRINA Gene

Localization for GRINA Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRINA Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRINA gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
golgi apparatus 3
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GRINA: view

Pathways & Interactions for GRINA Gene

genes like me logo Genes that share pathways with GRINA: view

Interacting Proteins for GRINA Gene

Gene Ontology (GO) - Biological Process for GRINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032469 endoplasmic reticulum calcium ion homeostasis IEA --
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with GRINA: view

No data available for SIGNOR curated interactions for GRINA Gene

Drugs & Compounds for GRINA Gene

No Compound Related Data Available

Transcripts for GRINA Gene

mRNA/cDNA for GRINA Gene

Unigene Clusters for GRINA Gene

Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRINA

Alternative Splicing Database (ASD) splice patterns (SP) for GRINA Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: -
SP2: - -
SP3: - - -
SP4: - -
SP5: - -

Relevant External Links for GRINA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRINA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRINA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRINA Gene

This gene is overexpressed in Whole Blood (x7.1).

Protein differential expression in normal tissues from HIPED for GRINA Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRINA Gene

Protein tissue co-expression partners for GRINA Gene

NURSA nuclear receptor signaling pathways regulating expression of GRINA Gene:


SOURCE GeneReport for Unigene cluster for GRINA Gene:


Evidence on tissue expression from TISSUES for GRINA Gene

  • Pancreas(4.8)
  • Lung(4.6)
  • Kidney(4.5)
  • Liver(4.5)
  • Nervous system(4.4)
  • Skin(3.4)
  • Eye(3)
  • Intestine(2.1)
  • Bone marrow(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with GRINA: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRINA Gene

Orthologs for GRINA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GRINA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GRINA 34 33
  • 99.46 (n)
(Bos Taurus)
Mammalia GRINA 34 33
  • 91.17 (n)
(Canis familiaris)
Mammalia GRINA 34 33
  • 90.54 (n)
(Rattus norvegicus)
Mammalia Grina 33
  • 89.56 (n)
(Mus musculus)
Mammalia Grina 16 34 33
  • 87.73 (n)
(Monodelphis domestica)
Mammalia GRINA 34
  • 83 (a)
(Anolis carolinensis)
Reptilia GRINA 34
  • 80 (a)
African clawed frog
(Xenopus laevis)
Amphibia grina-prov 33
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1396 33
(Danio rerio)
Actinopterygii zgc:136572 33
  • 68.41 (n)
  • 66 (a)
zgc64102 33
fruit fly
(Drosophila melanogaster)
Insecta Nmda1 33
  • 54.83 (n)
CG3814 34
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BXI1 34
  • 24 (a)
Species where no ortholog for GRINA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRINA Gene

Gene Tree for GRINA (if available)
Gene Tree for GRINA (if available)
Evolutionary constrained regions (ECRs) for GRINA: view image

Paralogs for GRINA Gene

Paralogs for GRINA Gene

(4) SIMAP similar genes for GRINA Gene using alignment to 6 proteins:

  • H0YC98_HUMAN
genes like me logo Genes that share paralogs with GRINA: view

Variants for GRINA Gene

Sequence variations from dbSNP and Humsavar for GRINA Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000602570 -- 143,990,929(+) A/G intron_variant
rs1001264450 -- 143,993,141(+) G/T 3_prime_UTR_variant
rs1002271584 -- 143,992,192(+) A/C intron_variant
rs1002850287 -- 143,988,529(+) G/A upstream_transcript_variant
rs1003404964 -- 143,988,715(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GRINA Gene

Variant ID Type Subtype PubMed ID
dgv12431n54 CNV loss 21841781
dgv12432n54 CNV loss 21841781
dgv12433n54 CNV gain 21841781
dgv906n27 CNV loss 19166990
nsv1075597 CNV deletion 25765185
nsv1161815 CNV deletion 26073780
nsv470249 CNV loss 18288195
nsv470250 CNV gain 18288195
nsv515809 CNV gain+loss 19592680
nsv612906 CNV loss 21841781
nsv612907 CNV gain+loss 21841781
nsv612914 CNV loss 21841781
nsv6445 CNV insertion 18451855
nsv950015 CNV deletion 24416366

Variation tolerance for GRINA Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRINA Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRINA Gene

Disorders for GRINA Gene

Additional Disease Information for GRINA

No disorders were found for GRINA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRINA Gene

Publications for GRINA Gene

  1. Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively. (PMID: 8406459) Collins C … Hayden MR (Genomics 1993) 2 3 4 22 58
  2. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 3 4 58
  3. Cloning of cDNA for the glutamate-binding subunit of an NMDA receptor complex. (PMID: 1719427) Kumar KN … Michaelis EK (Nature 1991) 2 3 58
  4. Extraintestinal manifestations of celiac disease: 33-mer gliadin binding to glutamate receptor GRINA as a new explanation. (PMID: 26990286) Garcia-Quintanilla A … Miranzo-Navarro D (BioEssays : news and reviews in molecular, cellular and developmental biology 2016) 3 58
  5. The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state. (PMID: 25764978) Lisak DA … Methner A (Biochimica et biophysica acta 2015) 3 58

Products for GRINA Gene

Sources for GRINA Gene

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