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Aliases for MRPS18B Gene

Aliases for MRPS18B Gene

  • Mitochondrial Ribosomal Protein S18B 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein BS18b 3 4
  • Mitochondrial Small Ribosomal Subunit Protein MS40 3 4
  • 28S Ribosomal Protein S18-2, Mitochondrial 3 4
  • MRP-S18-2 3 4
  • MRP-S18-B 3 4
  • Mrps18-B 3 4
  • C6orf14 3 4
  • S18mt-B 3 4
  • Mitochondrial Small Ribosomal Subunit Protein BS18m-B 3
  • 28S Ribosomal Protein S18b, Mitochondrial 3
  • Mitochondrial Ribosomal Protein S18-2 3
  • HumanS18a 3
  • MRPS18-2 3
  • HSPC183 3
  • PTD017 3
  • S18amt 3

External Ids for MRPS18B Gene

Previous GeneCards Identifiers for MRPS18B Gene

  • GC06P030641
  • GC06P030356
  • GC06P030691
  • GC06P030693
  • GC06P030585
  • GC06P030386

Summaries for MRPS18B Gene

Entrez Gene Summary for MRPS18B Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS18B Gene

MRPS18B (Mitochondrial Ribosomal Protein S18B) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS18B Gene

Additional gene information for MRPS18B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS18B Gene

Genomics for MRPS18B Gene

GeneHancer (GH) Regulatory Elements for MRPS18B Gene

Promoters and enhancers for MRPS18B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J030611 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 650.7 -1.8 -1768 8.7 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPP1R10 MRPS18B MDC1 DDX39B TRIM39 NRM DHX16 ZNRD1 ABCF1 TRIM26
GH06J030541 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.5 -74.4 -74419 3.7 PKNOX1 ATF1 ARID4B SIN3A ZNF2 IRF4 ZNF48 YY1 TCF12 ZNF213 ABCF1 PPP1R10 TRIM39 DHX16 MDC1 ZNRD1 DDX39B PAIP1P1 TRIM26 LINC02569
GH06J030735 Enhancer 1.2 Ensembl ENCODE dbSUPER 12 +119.8 119790 2.9 HDGF HDAC1 PKNOX1 SMAD1 RB1 BMI1 BATF IRF4 GATA2 ZNF366 ENSG00000201988 GC06M030736 PPP1R10 DHX16 MDC1 TRIM39 DDX39B PTMAP1 ATAT1 MRPS18B
GH06J030655 Enhancer 0.6 ENCODE 12.2 +39.6 39624 2.1 FOXA2 ZFP64 ZNF48 SP1 ZFHX2 CREB1 BCL6 ZNF600 HNF4A KDM1A DHX16 PTMAP1 ATAT1 PPP1R10 MRPS18B MDC1 MIR877 ABCF1 C6orf136
GH06J030625 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.4 +9.4 9416 2.2 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF143 KLF13 PAF1 ATAT1 PIR40859 PRRC2A TRIM39 MDC1 DHX16 ZNRD1ASP ABCF1 HLA-L HLA-J
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPS18B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS18B gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • deltaCREB
  • CREB
  • HOXA5
  • aMEF-2
  • MEF-2
  • MAZR
  • MEF-2A
  • Egr-2

Genomic Locations for MRPS18B Gene

Genomic Locations for MRPS18B Gene
9,078 bases
Plus strand
8,689 bases
Plus strand

Genomic View for MRPS18B Gene

Genes around MRPS18B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS18B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MRPS18B Gene

  • Protein details for MRPS18B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S18b, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6NDQ0
    • Q659G4
    • Q9BS27

    Protein attributes for MRPS18B Gene

    258 amino acids
    Molecular mass:
    29396 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mS40 has a zinc binding site.
    • There are 3 mitochondrial isoforms of bS18 in mammalia, localizing to 3 distinct sites in the mitoribosome. bS18m (bs18c) binds to the same site as bacterial bS18, mS40 (bS18b, this protein) binds to a novel location of the 28S small subunit, and mL66 (bS18a) binds to the 39S large subunit.

    Three dimensional structures from OCA and Proteopedia for MRPS18B Gene

neXtProt entry for MRPS18B Gene

Post-translational modifications for MRPS18B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS18B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS18B Gene

Domains & Families for MRPS18B Gene

Gene Families for MRPS18B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPS18B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
  • Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
genes like me logo Genes that share domains with MRPS18B: view

Function for MRPS18B Gene

Phenotypes From GWAS Catalog for MRPS18B Gene

Gene Ontology (GO) - Molecular Function for MRPS18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
GO:0005515 protein binding IPI 18391203
genes like me logo Genes that share ontologies with MRPS18B: view
genes like me logo Genes that share phenotypes with MRPS18B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS18B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS18B Gene

Localization for MRPS18B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS18B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS18B gene
Compartment Confidence
mitochondrion 5
nucleus 5
peroxisome 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Cell Junctions (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRPS18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA,IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit NAS 11279123
genes like me logo Genes that share ontologies with MRPS18B: view

Pathways & Interactions for MRPS18B Gene

genes like me logo Genes that share pathways with MRPS18B: view

Gene Ontology (GO) - Biological Process for MRPS18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0032543 mitochondrial translation ISS 11402041
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS18B: view

No data available for SIGNOR curated interactions for MRPS18B Gene

Drugs & Compounds for MRPS18B Gene

No Compound Related Data Available

Transcripts for MRPS18B Gene

mRNA/cDNA for MRPS18B Gene

Unigene Clusters for MRPS18B Gene

Mitochondrial ribosomal protein S18B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS18B

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS18B Gene

No ASD Table

Relevant External Links for MRPS18B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS18B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS18B Gene

mRNA differential expression in normal tissues according to GTEx for MRPS18B Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for MRPS18B Gene

This gene is overexpressed in Nasal epithelium (20.1), Breast (11.8), and Lavage (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPS18B Gene

Protein tissue co-expression partners for MRPS18B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS18B Gene:


SOURCE GeneReport for Unigene cluster for MRPS18B Gene:


Evidence on tissue expression from TISSUES for MRPS18B Gene

  • Nervous system(4.7)
  • Heart(4.4)
  • Blood(4.3)
  • Liver(2.5)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with MRPS18B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS18B Gene

Orthologs for MRPS18B Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS18B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPS18B 34 33
  • 99.74 (n)
(Canis familiaris)
Mammalia MRPS18B 34 33
  • 86.33 (n)
(Bos Taurus)
Mammalia MRPS18B 34 33
  • 86.18 (n)
(Mus musculus)
Mammalia Mrps18b 16 34 33
  • 82.02 (n)
(Rattus norvegicus)
Mammalia Mrps18b 33
  • 81.55 (n)
(Monodelphis domestica)
Mammalia MRPS18B 34
  • 73 (a)
(Anolis carolinensis)
Reptilia MRPS18B 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489063 33
  • 54.65 (n)
(Danio rerio)
Actinopterygii mrps18b 34 33
  • 53.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpS18b 35
  • 45 (a)
mRpS18B 34
  • 36 (a)
(Caenorhabditis elegans)
Secernentea mrps-18B 34
  • 24 (a)
Species where no ortholog for MRPS18B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS18B Gene

Gene Tree for MRPS18B (if available)
Gene Tree for MRPS18B (if available)
Evolutionary constrained regions (ECRs) for MRPS18B: view image

Paralogs for MRPS18B Gene Pseudogenes for MRPS18B Gene

genes like me logo Genes that share paralogs with MRPS18B: view

No data available for Paralogs for MRPS18B Gene

Variants for MRPS18B Gene

Sequence variations from dbSNP and Humsavar for MRPS18B Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000048094 -- 30,626,582(+) C/T downstream_transcript_variant
rs1000442325 -- 30,616,660(+) C/T upstream_transcript_variant
rs1000473154 -- 30,616,508(+) G/A upstream_transcript_variant
rs1000655568 -- 30,621,065(+) C/A/T intron_variant
rs1000967267 -- 30,617,785(+) G/C/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS18B Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv5244 CNV deletion 18451855
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv830626 CNV loss 17160897

Variation tolerance for MRPS18B Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS18B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS18B Gene

Disorders for MRPS18B Gene

Additional Disease Information for MRPS18B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPS18B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS18B Gene

Publications for MRPS18B Gene

  1. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 4 58
  2. Ribosome. The structure of the human mitochondrial ribosome. (PMID: 25838379) Amunts A … Ramakrishnan V (Science (New York, N.Y.) 2015) 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  5. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PMID: 16702430) Shiina T … Bahram S (Genetics 2006) 3 4 58

Products for MRPS18B Gene

Sources for MRPS18B Gene

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