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Aliases for TMEM176B Gene

Aliases for TMEM176B Gene

  • Transmembrane Protein 176B 2 3 3 5
  • LR8 3 4
  • LR8-Like Protein 3
  • Protein LR8 4
  • MS4B2 3

External Ids for TMEM176B Gene

Previous GeneCards Identifiers for TMEM176B Gene

  • GC07M150119
  • GC07M150488
  • GC07M144300

Summaries for TMEM176B Gene

GeneCards Summary for TMEM176B Gene

TMEM176B (Transmembrane Protein 176B) is a Protein Coding gene. An important paralog of this gene is TMEM176A.

UniProtKB/Swiss-Prot for TMEM176B Gene

  • May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity).

Additional gene information for TMEM176B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM176B Gene

Genomics for TMEM176B Gene

GeneHancer (GH) Regulatory Elements for TMEM176B Gene

Promoters and enhancers for TMEM176B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J150798 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 663.6 +0.9 930 3.7 RXRA RNF2 SUZ12 REST YY1 SMARCA4 ZNF512 RBM39 EZH2 TMEM176A TMEM176B ENSG00000244151 NUB1 AOC1
GH07J150876 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 650.2 -76.0 -76000 1.1 HDAC1 ARNT SIN3A ZNF2 RAD21 ZEB1 ZNF335 SCRT2 ZNF143 ATF7 LOC105375567 TMEM176B AOC1 GIMAP8 KCNH2
GH07J150780 Enhancer 1 Ensembl ENCODE dbSUPER 68.9 +20.0 20047 2.2 ZNF687 RXRA CEBPB CEBPG EBF1 MEF2B YY1 SP1 CEBPA HNF4A LOC105375566 TMEM176B TMEM176A AOC1 BET1P1
GH07J150778 Enhancer 1 Ensembl ENCODE 68.4 +22.1 22059 1.4 ATF1 RB1 ARNT IRF4 RAD21 RFX5 ZNF366 ZNF143 RCOR1 IKZF2 TMEM176B TMEM176A ENSG00000244151 NUB1 LOC105375566 BET1P1
GH07J150783 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 33.5 +14.1 14119 7 PKNOX1 ATF1 SMAD1 ARNT YY1 TCF12 GATA2 E2F8 ZFP91 ATF7 TMEM176A TMEM176B AOC1 ENSG00000244151 NUB1 GIMAP1 ZNF862 GIMAP2 AGAP3 GIMAP8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM176B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM176B gene promoter:
  • E2F
  • E2F-2
  • E2F-1
  • Nkx2-5

Genomic Locations for TMEM176B Gene

Genomic Locations for TMEM176B Gene
10,076 bases
Minus strand
10,076 bases
Minus strand

Genomic View for TMEM176B Gene

Genes around TMEM176B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM176B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM176B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM176B Gene

Proteins for TMEM176B Gene

  • Protein details for TMEM176B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 176B
    Protein Accession:
    Secondary Accessions:
    • B2RDK2
    • D3DWZ7
    • E9PAV4
    • Q5BJI2
    • Q9BT42
    • Q9Y609

    Protein attributes for TMEM176B Gene

    270 amino acids
    Molecular mass:
    29056 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH91471.1; Type=Erroneous termination; Positions=30; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM176B Gene


neXtProt entry for TMEM176B Gene

Post-translational modifications for TMEM176B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM176B Gene

Domains & Families for TMEM176B Gene

Gene Families for TMEM176B Gene

Protein Domains for TMEM176B Gene


Suggested Antigen Peptide Sequences for TMEM176B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM176 family.
  • Belongs to the TMEM176 family.
genes like me logo Genes that share domains with TMEM176B: view

Function for TMEM176B Gene

Molecular function for TMEM176B Gene

UniProtKB/Swiss-Prot Function:
May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated in fibrotic lung. Down-regulated in activated dendritic cells.

Phenotypes From GWAS Catalog for TMEM176B Gene

genes like me logo Genes that share phenotypes with TMEM176B: view

Animal Models for TMEM176B Gene

MGI Knock Outs for TMEM176B:

Animal Model Products

CRISPR Products

miRNA for TMEM176B Gene

miRTarBase miRNAs that target TMEM176B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM176B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM176B Gene

Localization for TMEM176B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM176B Gene

Nucleus membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM176B gene
Compartment Confidence
plasma membrane 3
nucleus 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM176B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with TMEM176B: view

Pathways & Interactions for TMEM176B Gene

SuperPathways for TMEM176B Gene

No Data Available

Interacting Proteins for TMEM176B Gene

Gene Ontology (GO) - Biological Process for TMEM176B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009887 animal organ morphogenesis TAS 9922225
GO:0030154 cell differentiation IEA --
GO:2001199 negative regulation of dendritic cell differentiation IEA --
genes like me logo Genes that share ontologies with TMEM176B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM176B Gene

Drugs & Compounds for TMEM176B Gene

No Compound Related Data Available

Transcripts for TMEM176B Gene

Unigene Clusters for TMEM176B Gene

Transmembrane protein 176B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM176B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM176B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: - - -

Relevant External Links for TMEM176B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM176B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM176B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM176B Gene

This gene is overexpressed in Liver (x17.3).

Protein differential expression in normal tissues from HIPED for TMEM176B Gene

This gene is overexpressed in Monocytes (22.3), Liver (21.6), Ovary (10.5), and Colon (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM176B Gene

Protein tissue co-expression partners for TMEM176B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM176B Gene:


SOURCE GeneReport for Unigene cluster for TMEM176B Gene:


mRNA Expression by UniProt/SwissProt for TMEM176B Gene:

Tissue specificity: Expressed in lung and dermal fibroblasts.

Evidence on tissue expression from TISSUES for TMEM176B Gene

  • Liver(4.7)
  • Lung(4.3)
  • Nervous system(4.3)
  • Kidney(3)
  • Heart(2.2)
  • Gall bladder(2.1)
  • Intestine(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with TMEM176B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM176B Gene

Orthologs for TMEM176B Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM176B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM176B 34 33
  • 99.51 (n)
(Bos Taurus)
Mammalia TMEM176B 34 33
  • 77.78 (n)
(Canis familiaris)
Mammalia TMEM176B 34 33
  • 77.65 (n)
(Mus musculus)
Mammalia Tmem176b 16 34 33
  • 69.44 (n)
(Rattus norvegicus)
Mammalia Tmem176b 33
  • 68.36 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 44 (a)
Species where no ortholog for TMEM176B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM176B Gene

Gene Tree for TMEM176B (if available)
Gene Tree for TMEM176B (if available)
Evolutionary constrained regions (ECRs) for TMEM176B: view image

Paralogs for TMEM176B Gene

Paralogs for TMEM176B Gene

(1) SIMAP similar genes for TMEM176B Gene using alignment to 1 proteins:

  • T176B_HUMAN
genes like me logo Genes that share paralogs with TMEM176B: view

Variants for TMEM176B Gene

Sequence variations from dbSNP and Humsavar for TMEM176B Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000385570 -- 150,801,115(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000409615 -- 150,798,280(-) G/A intron_variant
rs1000505564 -- 150,791,186(-) T/C downstream_transcript_variant
rs1000657366 -- 150,792,477(-) G/T intron_variant
rs1000693691 -- 150,800,282(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM176B Gene

Variant ID Type Subtype PubMed ID
dgv3695n106 OTHER inversion 24896259
esv3891235 CNV loss 25118596
nsv1030109 CNV gain 25217958
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv519444 CNV loss 19592680
nsv608990 CNV gain 21841781
nsv831187 CNV loss 17160897

Variation tolerance for TMEM176B Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.69; 89.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM176B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM176B Gene

Disorders for TMEM176B Gene

Additional Disease Information for TMEM176B

No disorders were found for TMEM176B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM176B Gene

Publications for TMEM176B Gene

  1. Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display. (PMID: 9922225) Lurton J … Narayanan AS (American journal of respiratory cell and molecular biology 1999) 2 3 4 58
  2. Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts. (PMID: 16095493) Louvet C … Cuturi MC (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus. (PMID: 27009467) Drujont L … Louvet C (Scientific reports 2016) 3 58

Products for TMEM176B Gene

Sources for TMEM176B Gene

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