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Aliases for MRPS28 Gene

Aliases for MRPS28 Gene

  • Mitochondrial Ribosomal Protein S28 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein BS1m 3 4
  • 28S Ribosomal Protein S35, Mitochondrial 3 4
  • MRP-S28 3 4
  • MRP-S35 3 4
  • MRPS35 3 4
  • S28mt 3 4
  • S35mt 3 4
  • 28S Ribosomal Protein S28, Mitochondrial 3
  • Mitochondrial 28S Ribosomal Protein S35 3
  • HSPC007 3

External Ids for MRPS28 Gene

Previous GeneCards Identifiers for MRPS28 Gene

  • GC08M079718
  • GC08M080879
  • GC08M080554
  • GC08M080881
  • GC08M080993
  • GC08M076320
  • GC08M080830

Summaries for MRPS28 Gene

Entrez Gene Summary for MRPS28 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS28 Gene

MRPS28 (Mitochondrial Ribosomal Protein S28) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.

Gene Wiki entry for MRPS28 Gene

Additional gene information for MRPS28 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS28 Gene

Genomics for MRPS28 Gene

GeneHancer (GH) Regulatory Elements for MRPS28 Gene

Promoters and enhancers for MRPS28 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J080026 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.5 1497 5.3 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 MEF2D MRPS28 TPD52 ENSG00000276418 ENSG00000272518
GH08J080167 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 650.1 -139.6 -139575 5.6 HDGF SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ZNF213 ZNF207 ZNF143 FOS TPD52 MRPS28 ENSG00000254205 RN7SL41P
GH08J079996 Promoter 0.6 EPDnew 661 +33.7 33710 0.1 HMBOX1 MRPS28 ENSG00000272518 ENSG00000276418
GH08J079766 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 15.9 +261.9 261862 3.9 PKNOX1 SMAD1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 FOS SP3 HEY1 LINC01607 MRPS28 RNU7-85P LOC101927040 GC08M079801
GH08J080078 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 -52.1 -52109 8.5 HDGF PKNOX1 FOXA2 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 IRF4 ZNF207 TPD52 ENSG00000276418 LOC105375918 MRPS28 ENSG00000254162 LOC105375919 ENSG00000254205
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPS28 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS28 gene promoter:
  • POU2F1c
  • POU2F1b
  • POU2F1a
  • POU2F1
  • Hlf
  • ATF-2

Genomic Locations for MRPS28 Gene

Genomic Locations for MRPS28 Gene
111,573 bases
Minus strand
111,573 bases
Minus strand

Genomic View for MRPS28 Gene

Genes around MRPS28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS28 Gene

Proteins for MRPS28 Gene

  • Protein details for MRPS28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S28, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2RDZ7
    • Q96Q21

    Protein attributes for MRPS28 Gene

    187 amino acids
    Molecular mass:
    20843 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS28 Gene

neXtProt entry for MRPS28 Gene

Post-translational modifications for MRPS28 Gene

  • Ubiquitination at isoforms=75
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MRPS28 Gene

Domains & Families for MRPS28 Gene

Gene Families for MRPS28 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Ribosomal proteins

Protein Domains for MRPS28 Gene


Suggested Antigen Peptide Sequences for MRPS28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bacterial ribosomal protein bS1 family.
  • Belongs to the bacterial ribosomal protein bS1 family.
genes like me logo Genes that share domains with MRPS28: view

Function for MRPS28 Gene

Phenotypes From GWAS Catalog for MRPS28 Gene

Gene Ontology (GO) - Molecular Function for MRPS28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with MRPS28: view
genes like me logo Genes that share phenotypes with MRPS28: view

Animal Model Products

miRNA for MRPS28 Gene

miRTarBase miRNAs that target MRPS28

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS28 Gene

Localization for MRPS28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS28 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS28 gene
Compartment Confidence
mitochondrion 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPS28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit TAS 10938081
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS28: view

Pathways & Interactions for MRPS28 Gene

genes like me logo Genes that share pathways with MRPS28: view

Gene Ontology (GO) - Biological Process for MRPS28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS28: view

No data available for SIGNOR curated interactions for MRPS28 Gene

Drugs & Compounds for MRPS28 Gene

No Compound Related Data Available

Transcripts for MRPS28 Gene

mRNA/cDNA for MRPS28 Gene

Unigene Clusters for MRPS28 Gene

Mitochondrial ribosomal protein S28:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS28 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: - -
SP3: -
SP4: - - - - -

Relevant External Links for MRPS28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS28 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6), Breast (10.1), Lung (9.6), and Pancreas (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MRPS28 Gene

Protein tissue co-expression partners for MRPS28 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS28 Gene:


SOURCE GeneReport for Unigene cluster for MRPS28 Gene:


Evidence on tissue expression from TISSUES for MRPS28 Gene

  • Nervous system(4.4)
  • Blood(4.1)
  • Heart(2.1)
  • Liver(2.1)
  • Muscle(2.1)
  • Kidney(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with MRPS28: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS28 Gene

Orthologs for MRPS28 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS28 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPS28 34 33
  • 98.22 (n)
(Bos Taurus)
Mammalia MRPS28 34 33
  • 86.56 (n)
(Canis familiaris)
Mammalia MRPS28 34 33
  • 84.59 (n)
(Mus musculus)
Mammalia Mrps28 16 34 33
  • 76.52 (n)
(Monodelphis domestica)
Mammalia MRPS28 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100124857 33
  • 64.5 (n)
Str.1431 33
(Danio rerio)
Actinopterygii mrps28 34 33
  • 56.59 (n)
Dr.14825 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4190 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006650 33
  • 54.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpS28 34 33
  • 54.14 (n)
(Caenorhabditis elegans)
Secernentea mrps-28 34
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 26 (a)
Species where no ortholog for MRPS28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS28 Gene

Gene Tree for MRPS28 (if available)
Gene Tree for MRPS28 (if available)
Evolutionary constrained regions (ECRs) for MRPS28: view image

Paralogs for MRPS28 Gene

(5) SIMAP similar genes for MRPS28 Gene using alignment to 9 proteins:

  • RT28_HUMAN
  • E5RK86_HUMAN
  • H0YC42_HUMAN
  • H7C5V3_HUMAN
genes like me logo Genes that share paralogs with MRPS28: view

No data available for Paralogs for MRPS28 Gene

Variants for MRPS28 Gene

Sequence variations from dbSNP and Humsavar for MRPS28 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000016614 -- 79,921,506(-) A/G intron_variant
rs1000030716 -- 80,003,998(-) C/A intron_variant
rs1000047104 -- 80,006,569(-) T/C intron_variant
rs1000096182 -- 79,919,861(-) A/G intron_variant
rs1000113992 -- 79,977,157(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS28 Gene

Variant ID Type Subtype PubMed ID
esv2666906 CNV deletion 23128226
esv3332416 CNV insertion 20981092
esv3572851 CNV loss 25503493
esv3617765 CNV loss 21293372
esv3617766 CNV loss 21293372
esv3617767 CNV gain 21293372
nsv951447 CNV duplication 24416366

Variation tolerance for MRPS28 Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.05; 60.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS28 Gene

Disorders for MRPS28 Gene

Additional Disease Information for MRPS28

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPS28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS28 Gene

Publications for MRPS28 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 58
  5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 3 4 58

Products for MRPS28 Gene

Sources for MRPS28 Gene

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