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Aliases for LIN9 Gene

Aliases for LIN9 Gene

  • Lin-9 DREAM MuvB Core Complex Component 2 3 5
  • Type I Interferon Receptor Beta Chain-Associated Protein 3 4
  • Beta Subunit-Associated Regulator Of Apoptosis 3 4
  • TUDOR Gene Similar Protein 3 4
  • Rb Related Pathway Actor 2 3
  • PRB-Associated Protein 3 4
  • BARA 3 4
  • TGS 3 4
  • Lin-9 Homolog (C. Elegans) 2
  • Protein Lin-9 Homolog 3
  • TUDOR Gene Similar 2
  • Lin-9 Homolog 3
  • HuLin-9 4
  • BARPsv 3
  • HLin-9 4
  • Lin-9 3
  • TGS1 3
  • TGS2 3

External Ids for LIN9 Gene

Previous GeneCards Identifiers for LIN9 Gene

  • GC01M222725
  • GC01M224485
  • GC01M226420
  • GC01M196936

Summaries for LIN9 Gene

Entrez Gene Summary for LIN9 Gene

  • This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for LIN9 Gene

LIN9 (Lin-9 DREAM MuvB Core Complex Component) is a Protein Coding gene. Diseases associated with LIN9 include Algoneurodystrophy and Tuberculous Peritonitis. Among its related pathways are Cell Cycle, Mitotic and Regulation of PLK1 Activity at G2/M Transition.

UniProtKB/Swiss-Prot for LIN9 Gene

  • Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.

Gene Wiki entry for LIN9 Gene

Additional gene information for LIN9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIN9 Gene

Genomics for LIN9 Gene

GeneHancer (GH) Regulatory Elements for LIN9 Gene

Promoters and enhancers for LIN9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J226307 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.7 665 3.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B GC01M226306 LIN9 ACBD3-AS1 H3F3A LOC105373110 ENAH LINC01703 ACBD3
GH01J226126 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +182.0 181963 2.7 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF121 ELK1 ZNF143 FOS ENSG00000270598 H3F3A LIN9 MIXL1 ACBD3 PARP1 PYCR2 GC01P226137
GH01J226121 Enhancer 1.5 Ensembl ENCODE dbSUPER 10.3 +186.5 186497 5.2 HDGF SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF766 ZNF213 H3F3A RPL34P7 ACBD3-AS1 MIXL1 SDE2 LIN9 LINC01703 ENSG00000270598 GC01P226093
GH01J226131 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.1 +176.1 176057 4.6 HDAC1 ELF3 PKNOX1 NFIB NEUROD1 SIN3A BMI1 ZNF48 YY1 ELK1 H3F3A ACBD3 MIXL1 LIN9 LINC01703 GC01P226137 ENSG00000270598
GH01J226348 Enhancer 1 Ensembl ENCODE 11.8 -40.1 -40137 2.7 HDAC1 RB1 NFIB TCF12 ZNF121 ZNF766 GATA2 EGR1 RUNX3 CREM ACBD3-AS1 ACBD3 LIN9 PARP1 MIXL1 LOC101060016
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LIN9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LIN9 gene promoter:
  • Elk-1
  • C/EBPalpha
  • POU2F1a
  • POU2F1
  • AML1a
  • c-Myb
  • MIF-1
  • RFX1
  • MyoD
  • En-1

Genomic Locations for LIN9 Gene

Genomic Locations for LIN9 Gene
78,951 bases
Minus strand
78,721 bases
Minus strand

Genomic View for LIN9 Gene

Genes around LIN9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIN9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIN9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIN9 Gene

Proteins for LIN9 Gene

  • Protein details for LIN9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein lin-9 homolog
    Protein Accession:
    Secondary Accessions:
    • Q5U5L8
    • Q5U7E1
    • Q6PI55
    • Q6ZTV4
    • Q7Z3J1

    Protein attributes for LIN9 Gene

    542 amino acids
    Molecular mass:
    61946 Da
    Quaternary structure:
    • Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RB1.
    • Sequence=AAH43444.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97871.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LIN9 Gene


neXtProt entry for LIN9 Gene

Post-translational modifications for LIN9 Gene

  • Ubiquitination at isoforms=2, 332
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LIN9 Gene

Domains & Families for LIN9 Gene

Gene Families for LIN9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LIN9 Gene


Suggested Antigen Peptide Sequences for LIN9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the lin-9 family.
  • Belongs to the lin-9 family.
genes like me logo Genes that share domains with LIN9: view

Function for LIN9 Gene

Molecular function for LIN9 Gene

UniProtKB/Swiss-Prot Function:
Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.

Gene Ontology (GO) - Molecular Function for LIN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0005515 protein binding IPI 17159899
genes like me logo Genes that share ontologies with LIN9: view
genes like me logo Genes that share phenotypes with LIN9: view

Animal Models for LIN9 Gene

MGI Knock Outs for LIN9:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIN9 Gene

Localization for LIN9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIN9 Gene

Nucleus, nucleoplasm. Note=Found in perinucleolar structures. Associated with chromatin.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIN9 gene
Compartment Confidence
nucleus 5
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LIN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0017053 transcriptional repressor complex IEA --
genes like me logo Genes that share ontologies with LIN9: view

Pathways & Interactions for LIN9 Gene

genes like me logo Genes that share pathways with LIN9: view

Pathways by source for LIN9 Gene

1 BioSystems pathway for LIN9 Gene
1 KEGG pathway for LIN9 Gene

SIGNOR curated interactions for LIN9 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for LIN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000003 reproduction IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0007049 cell cycle IEA --
GO:0051726 regulation of cell cycle TAS --
genes like me logo Genes that share ontologies with LIN9: view

Drugs & Compounds for LIN9 Gene

No Compound Related Data Available

Transcripts for LIN9 Gene

Unigene Clusters for LIN9 Gene

Lin-9 homolog (C. elegans):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIN9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP2: -

Relevant External Links for LIN9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LIN9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LIN9 Gene

mRNA differential expression in normal tissues according to GTEx for LIN9 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.4).

Protein differential expression in normal tissues from HIPED for LIN9 Gene

This gene is overexpressed in Heart (46.8), CD8 Tcells (9.9), and Testis (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LIN9 Gene

Protein tissue co-expression partners for LIN9 Gene

NURSA nuclear receptor signaling pathways regulating expression of LIN9 Gene:


SOURCE GeneReport for Unigene cluster for LIN9 Gene:


mRNA Expression by UniProt/SwissProt for LIN9 Gene:

Tissue specificity: Expressed in thymus and testis.

Evidence on tissue expression from TISSUES for LIN9 Gene

  • Heart(4.3)
  • Muscle(2.3)
  • Stomach(2.3)
  • Intestine(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with LIN9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for LIN9 Gene

Orthologs for LIN9 Gene

This gene was present in the common ancestor of animals.

Orthologs for LIN9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LIN9 34 33
  • 99.86 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 97 (a)
-- 34
  • 97 (a)
(Bos Taurus)
Mammalia LIN9 34 33
  • 95.04 (n)
(Ornithorhynchus anatinus)
Mammalia LIN9 34
  • 94 (a)
(Canis familiaris)
Mammalia LIN9 34 33
  • 92.79 (n)
(Mus musculus)
Mammalia Lin9 16 34 33
  • 89.98 (n)
(Rattus norvegicus)
Mammalia Lin9 33
  • 89.9 (n)
(Gallus gallus)
Aves LIN9 34 33
  • 84.48 (n)
(Anolis carolinensis)
Reptilia LIN9 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lin9 33
  • 76.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3885 33
(Danio rerio)
Actinopterygii LIN9 (2 of 2) 34
  • 79 (a)
lin9 34
  • 78 (a)
LOC100330674 33
  • 72.28 (n)
wufb79c09 33
fruit fly
(Drosophila melanogaster)
Insecta mip130 34 33
  • 45.98 (n)
aly 34
  • 20 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004624 33
  • 45.81 (n)
(Caenorhabditis elegans)
Secernentea lin-9 34 33
  • 49.13 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.27 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.27 33
Species where no ortholog for LIN9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LIN9 Gene

Gene Tree for LIN9 (if available)
Gene Tree for LIN9 (if available)
Evolutionary constrained regions (ECRs) for LIN9: view image

Paralogs for LIN9 Gene

No data available for Paralogs for LIN9 Gene

Variants for LIN9 Gene

Sequence variations from dbSNP and Humsavar for LIN9 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000015635 -- 226,242,792(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000063352 -- 226,272,721(-) C/T intron_variant
rs1000110835 -- 226,302,913(-) C/T intron_variant
rs1000149119 -- 226,281,776(-) C/T intron_variant
rs1000201485 -- 226,306,004(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LIN9 Gene

Variant ID Type Subtype PubMed ID
esv3589011 CNV gain 21293372
esv3891148 CNV loss 25118596
nsv517107 CNV gain+loss 19592680
nsv832759 CNV loss 17160897
nsv832770 CNV loss 17160897

Variation tolerance for LIN9 Gene

Residual Variation Intolerance Score: 9.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LIN9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIN9 Gene

Disorders for LIN9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LIN9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • reflex sympathetic dystrophy
tuberculous peritonitis
  • peritonitis tuberculous
- elite association - COSMIC cancer census association via MalaCards
Search LIN9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LIN9

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LIN9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIN9 Gene

Publications for LIN9 Gene

  1. Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein. (PMID: 15538385) Gagrica S … Gaubatz S (The EMBO journal 2004) 2 3 4 22 58
  2. LIN9, a subunit of the DREAM complex, regulates mitotic gene expression and proliferation of embryonic stem cells. (PMID: 23667535) Esterlechner J … Gaubatz S (PloS one 2013) 2 3 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest. (PMID: 20360844) Arking DE … Chugh SS (PloS one 2010) 3 44 58
  5. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PMID: 17531812) Litovchick L … DeCaprio JA (Molecular cell 2007) 3 4 58

Products for LIN9 Gene

Sources for LIN9 Gene

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