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Aliases for NKIRAS2 Gene

Aliases for NKIRAS2 Gene

  • NFKB Inhibitor Interacting Ras Like 2 2 3 5
  • NFKB Inhibitor Interacting Ras-Like Protein 2 2 3
  • I-Kappa-B-Interacting Ras-Like Protein 2 3 4
  • Kappa B-Ras Protein 2 3 4
  • KappaB-Ras2 3 4
  • KBRAS2 3 4
  • NF-Kappa-B Inhibitor-Interacting Ras-Like Protein 2 3
  • NFKB Inhibitor Interacting Ras-Like 2 2

External Ids for NKIRAS2 Gene

Previous GeneCards Identifiers for NKIRAS2 Gene

  • GC17P040546
  • GC17P037422
  • GC17P040170
  • GC17P035934

Summaries for NKIRAS2 Gene

GeneCards Summary for NKIRAS2 Gene

NKIRAS2 (NFKB Inhibitor Interacting Ras Like 2) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is NKIRAS1.

UniProtKB/Swiss-Prot for NKIRAS2 Gene

  • Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).

Gene Wiki entry for NKIRAS2 Gene

Additional gene information for NKIRAS2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKIRAS2 Gene

Genomics for NKIRAS2 Gene

GeneHancer (GH) Regulatory Elements for NKIRAS2 Gene

Promoters and enhancers for NKIRAS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I042019 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.4 +9.1 9051 2 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 DNAJC7 NKIRAS2 NT5C3B RETREG3 ENSG00000267758 PSME3 KAT2A
GH17I042015 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.4 +5.9 5922 2.9 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B DNAJC7 NKIRAS2 ENSG00000267758 CNTNAP1 ENSG00000259623 STAT5A NAGLU NT5C3B TUBG2 RETREG3
GH17I042010 Enhancer 1.1 Ensembl ENCODE dbSUPER 550.8 +0.6 588 3.9 KLF1 PKNOX1 ASH1L ZNF316 SCRT2 FOS ZNF600 SCRT1 CEBPB MAFG NKIRAS2 NT5C3B CNP ZNF385C DNAJC7
GH17I041674 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 25.6 -333.7 -333673 5.6 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT SIN3A YBX1 ZNF2 YY1 POLR2B ENSG00000267758 RETREG3 NKIRAS2 DHX58 TTC25 STAT5A ACLY STAT3 CAVIN1 LOC108783654
GH17I042672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 15.5 +667.3 667316 11.4 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 CNTNAP1 CCR10 PLEKHH3 ENSG00000267042 TUBG2 HSD17B1P1 ENSG00000267002 HMGN1P29 HMGN2P15 ENSG00000259623
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NKIRAS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NKIRAS2 gene promoter:

Genomic Locations for NKIRAS2 Gene

Genomic Locations for NKIRAS2 Gene
chr17:42,011,382-42,025,644
(GRCh38/hg38)
Size:
14,263 bases
Orientation:
Plus strand
chr17:40,163,400-40,177,659
(GRCh37/hg19)

Genomic View for NKIRAS2 Gene

Genes around NKIRAS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKIRAS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKIRAS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKIRAS2 Gene

Proteins for NKIRAS2 Gene

  • Protein details for NKIRAS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYR9-KBRS2_HUMAN
    Recommended name:
    NF-kappa-B inhibitor-interacting Ras-like protein 2
    Protein Accession:
    Q9NYR9
    Secondary Accessions:
    • A6NCZ5
    • B3KNN0
    • B4DNM3
    • Q6PK52
    • Q96KC7
    • Q9NSX1

    Protein attributes for NKIRAS2 Gene

    Size:
    191 amino acids
    Molecular mass:
    21508 Da
    Quaternary structure:
    • Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo.
    SequenceCaution:
    • Sequence=BAB55006.1; Type=Miscellaneous discrepancy; Note=Absence of residues from position 133 within an exon that change the frame which is not the result of an alternative splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for NKIRAS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NKIRAS2 Gene

Post-translational modifications for NKIRAS2 Gene

  • Ubiquitination at Lys167 and Lys174
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for NKIRAS2

No data available for DME Specific Peptides for NKIRAS2 Gene

Domains & Families for NKIRAS2 Gene

Gene Families for NKIRAS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9NYR9

UniProtKB/Swiss-Prot:

KBRS2_HUMAN :
  • In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
  • Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
Domain:
  • In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
Family:
  • Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
genes like me logo Genes that share domains with NKIRAS2: view

Function for NKIRAS2 Gene

Molecular function for NKIRAS2 Gene

UniProtKB/Swiss-Prot Function:
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).

Phenotypes From GWAS Catalog for NKIRAS2 Gene

Gene Ontology (GO) - Molecular Function for NKIRAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,NAS 10657303
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with NKIRAS2: view
genes like me logo Genes that share phenotypes with NKIRAS2: view

Animal Model Products

miRNA for NKIRAS2 Gene

miRTarBase miRNAs that target NKIRAS2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKIRAS2 Gene

Localization for NKIRAS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKIRAS2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKIRAS2 gene
Compartment Confidence
nucleus 3
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NKIRAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NKIRAS2: view

Pathways & Interactions for NKIRAS2 Gene

SuperPathways for NKIRAS2 Gene

SuperPathway Contained pathways
1 NF-KappaB Family Pathway
genes like me logo Genes that share pathways with NKIRAS2: view

Pathways by source for NKIRAS2 Gene

1 Qiagen pathway for NKIRAS2 Gene

Gene Ontology (GO) - Biological Process for NKIRAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling NAS 10657303
genes like me logo Genes that share ontologies with NKIRAS2: view

No data available for SIGNOR curated interactions for NKIRAS2 Gene

Drugs & Compounds for NKIRAS2 Gene

(1) Drugs for NKIRAS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with NKIRAS2: view

Transcripts for NKIRAS2 Gene

Unigene Clusters for NKIRAS2 Gene

NFKB inhibitor interacting Ras-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKIRAS2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
SP1: - - - -
SP2: - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - -

Relevant External Links for NKIRAS2 Gene

GeneLoc Exon Structure for
NKIRAS2
ECgene alternative splicing isoforms for
NKIRAS2

Expression for NKIRAS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKIRAS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NKIRAS2 Gene

This gene is overexpressed in Gallbladder (16.3), Fetal testis (9.3), Placenta (8.9), and Fetal Brain (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NKIRAS2 Gene



Protein tissue co-expression partners for NKIRAS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NKIRAS2 Gene:

NKIRAS2

SOURCE GeneReport for Unigene cluster for NKIRAS2 Gene:

Hs.632252

mRNA Expression by UniProt/SwissProt for NKIRAS2 Gene:

Q9NYR9-KBRS2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for NKIRAS2 Gene

  • Nervous system(4.7)
  • Muscle(4.4)
  • Eye(2)
genes like me logo Genes that share expression patterns with NKIRAS2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKIRAS2 Gene

Orthologs for NKIRAS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKIRAS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKIRAS2 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia NKIRAS2 33 34
  • 93.19 (n)
dog
(Canis familiaris)
Mammalia NKIRAS2 33 34
  • 92.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NKIRAS2 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkiras2 33 16 34
  • 90.92 (n)
rat
(Rattus norvegicus)
Mammalia Nkiras2 33
  • 90.75 (n)
oppossum
(Monodelphis domestica)
Mammalia NKIRAS2 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NKIRAS2 33 34
  • 82.37 (n)
lizard
(Anolis carolinensis)
Reptilia NKIRAS2 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nkiras2 33
  • 75.84 (n)
zebrafish
(Danio rerio)
Actinopterygii nkiras2 34 34
  • 77 (a)
OneToMany
LOC100538046 33
  • 73.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta kappaB-Ras 34
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F52A8.6 34
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToMany
Species where no ortholog for NKIRAS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NKIRAS2 Gene

ENSEMBL:
Gene Tree for NKIRAS2 (if available)
TreeFam:
Gene Tree for NKIRAS2 (if available)

Paralogs for NKIRAS2 Gene

Paralogs for NKIRAS2 Gene

genes like me logo Genes that share paralogs with NKIRAS2: view

Variants for NKIRAS2 Gene

Sequence variations from dbSNP and Humsavar for NKIRAS2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000355625 -- 42,016,313(+) C/T upstream_transcript_variant
rs1000968404 -- 42,020,649(+) T/C intron_variant
rs1001235155 -- 42,020,452(+) A/G intron_variant
rs1001642071 -- 42,023,401(+) A/G intron_variant
rs1001904681 -- 42,022,931(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NKIRAS2 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159

Variation tolerance for NKIRAS2 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NKIRAS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKIRAS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKIRAS2 Gene

Disorders for NKIRAS2 Gene

Additional Disease Information for NKIRAS2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NKIRAS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKIRAS2 Gene

Publications for NKIRAS2 Gene

  1. A subclass of Ras proteins that regulate the degradation of IkappaB. (PMID: 10657303) Fenwick C … Ghosh S (Science (New York, N.Y.) 2000) 2 3 4 58
  2. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PMID: 18434448) Dieguez-Gonzalez R … Gonzalez A (Annals of the rheumatic diseases 2009) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for NKIRAS2 Gene

Sources for NKIRAS2 Gene

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