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Aliases for JAKMIP3 Gene

Aliases for JAKMIP3 Gene

  • Janus Kinase And Microtubule Interacting Protein 3 2 3 5
  • Neuroendocrine Long Coiled-Coil Protein 2 3 4
  • Neuroendocrine Long Coiled-Coil 2 2 3
  • C10orf14 3 4
  • C10orf39 3 4
  • NECC2 3 4
  • Janus Kinase And Microtubule-Interacting Protein 3 3
  • Chromosome 10 Open Reading Frame 39 2
  • Chromosome 10 Open Reading Frame 14 2
  • BA140A10.5 3
  • Jamip3 3
  • JAMIP3 4

External Ids for JAKMIP3 Gene

Previous HGNC Symbols for JAKMIP3 Gene

  • C10orf39
  • C10orf14

Previous GeneCards Identifiers for JAKMIP3 Gene

  • GC10P133769
  • GC10P133918
  • GC10P127467

Summaries for JAKMIP3 Gene

GeneCards Summary for JAKMIP3 Gene

JAKMIP3 (Janus Kinase And Microtubule Interacting Protein 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include microtubule binding and kinase binding. An important paralog of this gene is JAKMIP1.

Additional gene information for JAKMIP3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JAKMIP3 Gene

Genomics for JAKMIP3 Gene

GeneHancer (GH) Regulatory Elements for JAKMIP3 Gene

Promoters and enhancers for JAKMIP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J132035 Enhancer 1.1 Ensembl ENCODE dbSUPER 657.9 +0.6 645 2.5 CTCF MXI1 SIN3A ZIC2 ZNF335 GLIS2 POLR2A SCRT2 ZNF600 EZH2 JAKMIP3 BNIP3 DPYSL4
GH10J132060 Enhancer 0.5 FANTOM5 dbSUPER 22.2 +24.2 24221 0.1 JAKMIP3 BNIP3 DPYSL4
GH10J132536 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4 +502.5 502514 5.1 HDGF PKNOX1 ATF1 ARID4B SIN3A BRCA1 YY1 ELK1 ZNF207 ZNF143 INPP5A PAOX JAKMIP3 CFAP46 NKX6-2 PIR45643
GH10J132022 Enhancer 1.3 FANTOM5 Ensembl ENCODE 6 -12.8 -12775 0.9 ELF3 RB1 ARID4B SIN3A IRF4 ZNF48 RAD21 ZNF614 ARID2 ZNF143 BNIP3 JAKMIP3 STK32C DPYSL4 ENSG00000279982
GH10J132443 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 5 +410.3 410315 5.4 HDGF ARID4B ZNF48 GLIS2 KLF7 RUNX3 DEK SP3 SP5 NCOA1 C10orf91 JAKMIP3 LOC105378569
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JAKMIP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the JAKMIP3 gene promoter:
  • AREB6
  • RORalpha2
  • COMP1
  • GR-beta
  • GR-alpha
  • GR
  • HNF-4alpha2
  • HNF-4alpha1
  • ATF6
  • POU3F2 (N-Oct-5b)

Genomic Locations for JAKMIP3 Gene

Genomic Locations for JAKMIP3 Gene
148,703 bases
Plus strand
80,139 bases
Plus strand

Genomic View for JAKMIP3 Gene

Genes around JAKMIP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JAKMIP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JAKMIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JAKMIP3 Gene

Proteins for JAKMIP3 Gene

  • Protein details for JAKMIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Janus kinase and microtubule-interacting protein 3
    Protein Accession:
    Secondary Accessions:
    • A6PW00
    • Q69YM6
    • Q6ZT29

    Protein attributes for JAKMIP3 Gene

    844 amino acids
    Molecular mass:
    98529 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC86766.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH10388.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH10388.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for JAKMIP3 Gene


neXtProt entry for JAKMIP3 Gene

Post-translational modifications for JAKMIP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for JAKMIP3 Gene

Domains & Families for JAKMIP3 Gene

Gene Families for JAKMIP3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for JAKMIP3 Gene


Suggested Antigen Peptide Sequences for JAKMIP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the JAKMIP family.
  • Belongs to the JAKMIP family.
genes like me logo Genes that share domains with JAKMIP3: view

Function for JAKMIP3 Gene

Phenotypes From GWAS Catalog for JAKMIP3 Gene

Gene Ontology (GO) - Molecular Function for JAKMIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IEA --
GO:0019900 kinase binding IEA --
genes like me logo Genes that share ontologies with JAKMIP3: view

Phenotypes for JAKMIP3 Gene

genes like me logo Genes that share phenotypes with JAKMIP3: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for JAKMIP3 Gene

Localization for JAKMIP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JAKMIP3 Gene

Golgi apparatus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JAKMIP3 gene
Compartment Confidence
golgi apparatus 4
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for JAKMIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with JAKMIP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for JAKMIP3 Gene

Pathways & Interactions for JAKMIP3 Gene

SuperPathways for JAKMIP3 Gene

No Data Available

Interacting Proteins for JAKMIP3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000298622 for JAKMIP3 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for JAKMIP3 Gene


No data available for Pathways by source and SIGNOR curated interactions for JAKMIP3 Gene

Drugs & Compounds for JAKMIP3 Gene

No Compound Related Data Available

Transcripts for JAKMIP3 Gene

mRNA/cDNA for JAKMIP3 Gene

(17) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for JAKMIP3 Gene

Janus kinase and microtubule interacting protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for JAKMIP3 Gene

No ASD Table

Relevant External Links for JAKMIP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for JAKMIP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JAKMIP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for JAKMIP3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3).

Protein differential expression in normal tissues from HIPED for JAKMIP3 Gene

This gene is overexpressed in Liver (51.2) and Urine (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for JAKMIP3 Gene

Protein tissue co-expression partners for JAKMIP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of JAKMIP3 Gene:


SOURCE GeneReport for Unigene cluster for JAKMIP3 Gene:


mRNA Expression by UniProt/SwissProt for JAKMIP3 Gene:

Tissue specificity: Specifically expressed in the CNS and endocrine tissues. Also detected in other tissues including heart, testis and prostate.

Evidence on tissue expression from TISSUES for JAKMIP3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with JAKMIP3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for JAKMIP3 Gene

Orthologs for JAKMIP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for JAKMIP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia JAKMIP3 34 33
  • 97.44 (n)
(Bos Taurus)
Mammalia JAKMIP3 34 33
  • 88.98 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
-- 34
  • 86 (a)
-- 34
  • 77 (a)
(Canis familiaris)
Mammalia JAKMIP3 34 33
  • 87.61 (n)
(Rattus norvegicus)
Mammalia Jakmip3 33
  • 87.4 (n)
(Mus musculus)
Mammalia Jakmip3 16 34 33
  • 87.32 (n)
(Monodelphis domestica)
Mammalia JAKMIP3 34
  • 86 (a)
(Gallus gallus)
Aves JAKMIP3 34 33
  • 81.97 (n)
(Anolis carolinensis)
Reptilia JAKMIP3 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia jakmip3 33
  • 76.41 (n)
(Danio rerio)
Actinopterygii JAKMIP3 34
  • 78 (a)
LOC100334213 33
  • 72.92 (n)
Species where no ortholog for JAKMIP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JAKMIP3 Gene

Gene Tree for JAKMIP3 (if available)
Gene Tree for JAKMIP3 (if available)
Evolutionary constrained regions (ECRs) for JAKMIP3: view image

Paralogs for JAKMIP3 Gene

Paralogs for JAKMIP3 Gene

(2) SIMAP similar genes for JAKMIP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with JAKMIP3: view

Variants for JAKMIP3 Gene

Sequence variations from dbSNP and Humsavar for JAKMIP3 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
VAR_039473 A breast cancer sample p.Arg795Gly
rs1000014807 -- 132,094,439(+) C/T intron_variant
rs1000031580 -- 132,085,197(+) C/G intron_variant
rs1000034852 -- 132,179,396(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000045541 -- 132,100,727(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for JAKMIP3 Gene

Variant ID Type Subtype PubMed ID
dgv551n106 CNV duplication 24896259
dgv552n106 CNV deletion 24896259
esv1281400 CNV deletion 17803354
esv1290967 CNV insertion 17803354
esv1418735 CNV insertion 17803354
esv21792 CNV gain+loss 19812545
esv2301386 CNV deletion 18987734
esv2643236 CNV insertion 19546169
esv2656970 CNV deletion 23128226
esv2669676 CNV deletion 23128226
esv2674885 CNV deletion 23128226
esv2675722 CNV deletion 23128226
esv2743610 CNV deletion 23290073
esv2743611 CNV deletion 23290073
esv2743612 CNV deletion 23290073
esv2743613 CNV deletion 23290073
esv2743614 CNV deletion 23290073
esv2743615 CNV deletion 23290073
esv2743616 CNV deletion 23290073
esv2743617 CNV deletion 23290073
esv2743618 CNV deletion 23290073
esv2743620 CNV deletion 23290073
esv2743621 CNV deletion 23290073
esv2743622 CNV deletion 23290073
esv2743623 CNV deletion 23290073
esv2743624 CNV deletion 23290073
esv2743625 CNV deletion 23290073
esv2743626 CNV deletion 23290073
esv2743627 CNV deletion 23290073
esv2761642 CNV gain 21179565
esv2851 CNV loss 18987735
esv3397852 CNV duplication 20981092
esv3425398 CNV duplication 20981092
esv3547095 CNV deletion 23714750
esv3624956 CNV gain 21293372
esv996010 CNV deletion 20482838
nsv1054569 CNV gain 25217958
nsv1054934 CNV gain 25217958
nsv1069523 CNV deletion 25765185
nsv1070907 CNV deletion 25765185
nsv1113349 CNV deletion 24896259
nsv1113350 CNV deletion 24896259
nsv1122573 CNV deletion 24896259
nsv1126274 CNV deletion 24896259
nsv1134075 CNV deletion 24896259
nsv1140460 CNV tandem duplication 24896259
nsv1141058 CNV deletion 24896259
nsv1148994 CNV duplication 26484159
nsv523296 CNV loss 19592680
nsv552502 CNV loss 21841781
nsv552503 CNV loss 21841781
nsv552504 CNV loss 21841781
nsv825652 CNV gain 20364138
nsv825654 CNV gain 20364138
nsv825655 CNV gain 20364138
nsv832030 CNV loss 17160897
nsv951885 CNV deletion 24416366

Variation tolerance for JAKMIP3 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.70; 78.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JAKMIP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JAKMIP3 Gene

Disorders for JAKMIP3 Gene

Additional Disease Information for JAKMIP3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for JAKMIP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JAKMIP3 Gene

Publications for JAKMIP3 Gene

  1. Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins. (PMID: 17572408) Cruz-Garcia D … Malagon MM (FEBS letters 2007) 2 3 4 58
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  3. Jamip1 (marlin-1) defines a family of proteins interacting with janus kinases and microtubules. (PMID: 15277531) Steindler C … Pellegrini S (The Journal of biological chemistry 2004) 2 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58

Products for JAKMIP3 Gene

Sources for JAKMIP3 Gene

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