Aliases for IFNL1 Gene
External Ids for IFNL1 Gene
Previous HGNC Symbols for IFNL1 Gene
Previous GeneCards Identifiers for IFNL1 Gene
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
GeneCards Summary for IFNL1 Gene
IFNL1 (Interferon Lambda 1) is a Protein Coding gene. Diseases associated with IFNL1 include Microphthalmia With Limb Anomalies. Among its related pathways are Type III Interferon Signaling Pathways and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and interleukin-28 receptor binding. An important paralog of this gene is IFNL3.
UniProtKB/Swiss-Prot for IFNL1 Gene
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.