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Aliases for GOLGA1 Gene

Aliases for GOLGA1 Gene

  • Golgin A1 2 3 5
  • Golgi Autoantigen, Golgin Subfamily A, 1 2 3
  • Golgin-97 3 4
  • Gap Junction Protein, Alpha 4, 37kD 3
  • Golgin Subfamily A Member 1 3

External Ids for GOLGA1 Gene

Previous GeneCards Identifiers for GOLGA1 Gene

  • GC09M118755
  • GC09M119287
  • GC09M121094
  • GC09M123016
  • GC09M124720
  • GC09M126680
  • GC09M127640
  • GC09M097252

Summaries for GOLGA1 Gene

Entrez Gene Summary for GOLGA1 Gene

  • The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein is associated with Sjogren's syndrome. [provided by RefSeq, Feb 2010]

GeneCards Summary for GOLGA1 Gene

GOLGA1 (Golgin A1) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport.

UniProtKB/Swiss-Prot for GOLGA1 Gene

  • Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking.

Gene Wiki entry for GOLGA1 Gene

Additional gene information for GOLGA1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGA1 Gene

Genomics for GOLGA1 Gene

GeneHancer (GH) Regulatory Elements for GOLGA1 Gene

Promoters and enhancers for GOLGA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J124939 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 660.8 +7.2 7183 3 HDGF SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GOLGA1 GC09P124941 GAPVD1 ARPC5L PRPS1P2 SCAI PPP6C GC09M124944
GH09J124950 Enhancer 0.8 ENCODE 650.7 -1.8 -1825 0.6 FOXA2 MLX ARID4B DMAP1 THRB RAD21 RARA YY1 SMARCC2 CREM GC09M124947 GOLGA1 FXNP2 SCAI
GH09J124414 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 40.3 +533.4 533426 2.1 HDGF HNRNPUL1 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 PSMB7 GAPVD1 GOLGA1 PRPS1P2 NEK6 GC09P124378
GH09J124768 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 38.3 +177.8 177839 3.5 CLOCK MLX FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000236643 NR6A1 PRPS1P2 GAPVD1 GOLGA1 WDR38 ARPC5L RPL35 MIR181A2HG
GH09J125744 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 34.3 -798.7 -798680 4.9 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B PBX3 LOC51145 GOLGA1 GAPVD1 PRPS1P2 PPP6C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLGA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GOLGA1 gene promoter:
  • Pbx1a
  • Nkx3-1 v4
  • HFH-1
  • FOXD3
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • FOXJ2 (long isoform)
  • FOXJ2

Genomic Locations for GOLGA1 Gene

Genomic Locations for GOLGA1 Gene
chr9:124,878,294-124,948,492
(GRCh38/hg38)
Size:
70,199 bases
Orientation:
Minus strand
chr9:127,640,573-127,710,771
(GRCh37/hg19)
Size:
70,199 bases
Orientation:
Minus strand

Genomic View for GOLGA1 Gene

Genes around GOLGA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA1 Gene

Proteins for GOLGA1 Gene

  • Protein details for GOLGA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92805-GOGA1_HUMAN
    Recommended name:
    Golgin subfamily A member 1
    Protein Accession:
    Q92805
    Secondary Accessions:
    • Q5T164
    • Q8IYZ9

    Protein attributes for GOLGA1 Gene

    Size:
    767 amino acids
    Molecular mass:
    88184 Da
    Quaternary structure:
    • Interacts with RAB6A (PubMed:10209123). Directly interacts with TBC1D23 (PubMed:29084197). Interacts with FAM91A1; this interaction may mediated by TBC1D23 (PubMed:29084197).
    Miscellaneous:
    • Antibodies against GOLGA1 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.

neXtProt entry for GOLGA1 Gene

Post-translational modifications for GOLGA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLGA1 Gene

Antibody Products

No data available for DME Specific Peptides for GOLGA1 Gene

Domains & Families for GOLGA1 Gene

Gene Families for GOLGA1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GOLGA1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLGA1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GOLGA1: view

No data available for UniProtKB/Swiss-Prot for GOLGA1 Gene

Function for GOLGA1 Gene

Molecular function for GOLGA1 Gene

UniProtKB/Swiss-Prot Function:
Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking.

Gene Ontology (GO) - Molecular Function for GOLGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GOLGA1: view
genes like me logo Genes that share phenotypes with GOLGA1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA1 Gene

Localization for GOLGA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA1 Gene

Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane. Cytoplasmic vesicle, secretory vesicle, acrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLGA1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 3
endosome 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GOLGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0001669 acrosomal vesicle IEA --
GO:0005794 Golgi apparatus IDA,TAS 17724343
GO:0005802 trans-Golgi network IDA,IEA 17488291
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GOLGA1: view

Pathways & Interactions for GOLGA1 Gene

genes like me logo Genes that share pathways with GOLGA1: view

Gene Ontology (GO) - Biological Process for GOLGA1 Gene

None

No data available for SIGNOR curated interactions for GOLGA1 Gene

Drugs & Compounds for GOLGA1 Gene

(1) Additional Compounds for GOLGA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GOLGA1: view

Transcripts for GOLGA1 Gene

mRNA/cDNA for GOLGA1 Gene

Unigene Clusters for GOLGA1 Gene

Golgin A1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - -
SP2:
SP3: - - -
SP4: -
SP5:
SP6: -
SP7: - - -
SP8: - -
SP9:
SP10:
SP11:
SP12:

ExUns: 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b · 22c ^ 23 ^ 24
SP1: - - -
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for GOLGA1 Gene

GeneLoc Exon Structure for
GOLGA1
ECgene alternative splicing isoforms for
GOLGA1

Expression for GOLGA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GOLGA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GOLGA1 Gene

This gene is overexpressed in Plasma (18.0), Ovary (6.6), Pancreas (6.5), and Colon muscle (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GOLGA1 Gene



NURSA nuclear receptor signaling pathways regulating expression of GOLGA1 Gene:

GOLGA1

SOURCE GeneReport for Unigene cluster for GOLGA1 Gene:

Hs.133469

Evidence on tissue expression from TISSUES for GOLGA1 Gene

  • Liver(4.2)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with GOLGA1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA1 Gene

Orthologs for GOLGA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GOLGA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLGA1 34 33
  • 99.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GOLGA1 34 33
  • 88.24 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GOLGA1 34 33
  • 87.3 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Golga1 16 34 33
  • 83.6 (n)
rat
(Rattus norvegicus)
Mammalia Golga1 33
  • 83.25 (n)
oppossum
(Monodelphis domestica)
Mammalia GOLGA1 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
OneToMany
-- 34
  • 47 (a)
OneToMany
chicken
(Gallus gallus)
Aves GOLGA1 34 33
  • 66.23 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOLGA1 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia golga1 33
  • 59.86 (n)
zebrafish
(Danio rerio)
Actinopterygii golga1 34 33
  • 58.6 (n)
OneToOne
-- 33
fruit fly
(Drosophila melanogaster)
Insecta cbs 34
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToMany
-- 34
  • 21 (a)
OneToMany
Species where no ortholog for GOLGA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GOLGA1 Gene

ENSEMBL:
Gene Tree for GOLGA1 (if available)
TreeFam:
Gene Tree for GOLGA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GOLGA1: view image

Paralogs for GOLGA1 Gene

No data available for Paralogs for GOLGA1 Gene

Variants for GOLGA1 Gene

Sequence variations from dbSNP and Humsavar for GOLGA1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000035087 -- 124,930,606(-) C/G intron_variant
rs1000080621 -- 124,926,940(-) T/C intron_variant
rs1000124451 -- 124,882,384(-) C/T intron_variant
rs1000159124 -- 124,879,024(-) A/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000264322 -- 124,923,575(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GOLGA1 Gene

Variant ID Type Subtype PubMed ID
esv2658018 CNV deletion 23128226
esv2739038 CNV deletion 23290073
esv2739039 CNV deletion 23290073
esv3573384 CNV loss 25503493
esv3621728 CNV loss 21293372
esv3621729 CNV loss 21293372
nsv825075 CNV loss 20364138

Variation tolerance for GOLGA1 Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLGA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLGA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA1 Gene

Disorders for GOLGA1 Gene

Additional Disease Information for GOLGA1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GOLGA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLGA1 Gene

Publications for GOLGA1 Gene

  1. Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjögren's syndrome. (PMID: 9324025) Griffith KJ … Fritzler MJ (Arthritis and rheumatism 1997) 2 3 4 22 58
  2. A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins. (PMID: 10209123) Barr FA (Current biology : CB 1999) 3 4 22 58
  3. TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi. (PMID: 29084197) Shin JJH … Munro S (Nature cell biology 2017) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A … Vieira AR (American journal of medical genetics. Part A 2010) 3 44 58

Products for GOLGA1 Gene

Sources for GOLGA1 Gene

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