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Aliases for GNG7 Gene

Aliases for GNG7 Gene

  • G Protein Subunit Gamma 7 2 3 5
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 7 2 3
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-7 3
  • GNGT7 4

External Ids for GNG7 Gene

Previous GeneCards Identifiers for GNG7 Gene

  • GC19M002577
  • GC19M002454
  • GC19M002463
  • GC19M002464
  • GC19M002465
  • GC19M002283

Summaries for GNG7 Gene

GeneCards Summary for GNG7 Gene

GNG7 (G Protein Subunit Gamma 7) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and G-protein signaling G-Protein alpha-i signaling cascades. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is GNG12.

UniProtKB/Swiss-Prot for GNG7 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).

Tocris Summary for GNG7 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG7 Gene

Additional gene information for GNG7 Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG7 Gene

Genomics for GNG7 Gene

GeneHancer (GH) Regulatory Elements for GNG7 Gene

Promoters and enhancers for GNG7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J002701 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 658.5 +0.5 521 2.3 PKNOX1 ATF1 ZFP64 KLF17 GTF3C2 ZNF614 GLIS2 SCRT2 ZNF143 ATF7 GNG7 ENSG00000276097 LSM7 SF3A2 LOC100288123 CACTIN-AS1 CACTIN ZNF77 ENSG00000267139 DOT1L
GH19J002700 Enhancer 0.7 FANTOM5 dbSUPER 664.9 +1.8 1806 0.3 ZFHX2 L3MBTL2 ZSCAN5C ZNF600 MLLT1 EGR2 GNG7 ENSG00000276097 LINGO3 TMPRSS9 ZNF555 PIR43863
GH19J003363 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 -665.0 -664989 8.1 HDGF SMAD1 ARNT YBX1 ZNF2 YY1 POLR2B ZNF213 ZNF143 ZNF263 NFIC CACTIN-AS1 CACTIN YJU2 ZNF77 APBA3 LMNB2 PIAS4 ENSG00000267139 ZNF555
GH19J003605 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 9.8 -904.9 -904855 4.6 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF2 POLR2B ZNF766 SP3 MCM5 CACTIN-AS1 TBXA2R ZNF77 CACTIN ENSG00000267030 ZNF555 ENSG00000267769 YJU2 APBA3 GNA11
GH19J002693 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 15.7 +7.7 7650 3.1 ZNF146 ZNF311 ZNF514 NR2F2 ZFHX2 ZNF366 BCL6B ZNF512 PRDM1 ZNF77 CACTIN-AS1 DIRAS1 CACTIN GNG7 SLC39A3 ZNF556 LINGO3 ENSG00000276097 PIR43863
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNG7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GNG7 gene promoter:
  • POU2F1
  • POU2F1a
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2
  • RFX1

Genomic Locations for GNG7 Gene

Genomic Locations for GNG7 Gene
191,530 bases
Minus strand
191,491 bases
Minus strand

Genomic View for GNG7 Gene

Genes around GNG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG7 Gene

Proteins for GNG7 Gene

  • Protein details for GNG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
    Protein Accession:
    Secondary Accessions:
    • B2R496

    Protein attributes for GNG7 Gene

    68 amino acids
    Molecular mass:
    7522 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma.

neXtProt entry for GNG7 Gene

Post-translational modifications for GNG7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG7 Gene

Domains & Families for GNG7 Gene

Gene Families for GNG7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GNG7 Gene

Suggested Antigen Peptide Sequences for GNG7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G protein gamma family.
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG7: view

Function for GNG7 Gene

Molecular function for GNG7 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).

Phenotypes From GWAS Catalog for GNG7 Gene

genes like me logo Genes that share phenotypes with GNG7: view

Animal Models for GNG7 Gene

MGI Knock Outs for GNG7:

Animal Model Products

  • Taconic Biosciences Mouse Models for GNG7

miRNA for GNG7 Gene

Clone Products

  • Addgene plasmids for GNG7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNG7 Gene

Localization for GNG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG7 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG7 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for GNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with GNG7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GNG7 Gene

Pathways & Interactions for GNG7 Gene

genes like me logo Genes that share pathways with GNG7: view

Gene Ontology (GO) - Biological Process for GNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 9600093
GO:0071377 cellular response to glucagon stimulus TAS --
genes like me logo Genes that share ontologies with GNG7: view

No data available for SIGNOR curated interactions for GNG7 Gene

Drugs & Compounds for GNG7 Gene

(3) Drugs for GNG7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG7 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
G-Protein antagonist peptide
Gue 1654
SCH 202676 hydrobromide

(5) Tocris Compounds for GNG7 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Gue 1654 Selective inhibitor of OXE-R Gbetagamma signaling 397290-30-1
Mastoparan Activates Gi and Go 72093-21-1
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG7: view

Transcripts for GNG7 Gene

mRNA/cDNA for GNG7 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(95) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNG7 Gene

Guanine nucleotide binding protein (G protein), gamma 7:
Representative Sequences:

Clone Products

  • Addgene plasmids for GNG7

Alternative Splicing Database (ASD) splice patterns (SP) for GNG7 Gene

No ASD Table

Relevant External Links for GNG7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNG7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG7 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x11.8), Brain - Caudate (basal ganglia) (x9.8), and Brain - Nucleus accumbens (basal ganglia) (x9.2).

Protein differential expression in normal tissues from HIPED for GNG7 Gene

This gene is overexpressed in Frontal cortex (23.2) and Spinal cord (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNG7 Gene

Protein tissue co-expression partners for GNG7 Gene

NURSA nuclear receptor signaling pathways regulating expression of GNG7 Gene:


SOURCE GeneReport for Unigene cluster for GNG7 Gene:


mRNA Expression by UniProt/SwissProt for GNG7 Gene:

Tissue specificity: Expressed in a variety of tissues. Down-regulated in pancreatic and esophageal cancer.

Evidence on tissue expression from TISSUES for GNG7 Gene

  • Nervous system(4.9)
  • Skin(4)
genes like me logo Genes that share expression patterns with GNG7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG7 Gene

Orthologs for GNG7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GNG7 34 33
  • 98.53 (n)
(Monodelphis domestica)
Mammalia GNG7 34
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia GNG7 34
  • 91 (a)
(Bos Taurus)
Mammalia GNG7 34 33
  • 90.69 (n)
(Canis familiaris)
Mammalia GNG7 34 33
  • 88.73 (n)
(Mus musculus)
Mammalia Gng7 16 34 33
  • 83.33 (n)
(Rattus norvegicus)
Mammalia Gng7 33
  • 82.84 (n)
(Gallus gallus)
Aves GNG7 34
  • 91 (a)
LOC100858976 33
  • 82.84 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gng7 33
  • 76.96 (n)
(Danio rerio)
Actinopterygii gng7 34 33
  • 78.92 (n)
Species where no ortholog for GNG7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG7 Gene

Gene Tree for GNG7 (if available)
Gene Tree for GNG7 (if available)
Evolutionary constrained regions (ECRs) for GNG7: view image

Paralogs for GNG7 Gene

Paralogs for GNG7 Gene

(10) SIMAP similar genes for GNG7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNG7: view

Variants for GNG7 Gene

Sequence variations from dbSNP and Humsavar for GNG7 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000003222 -- 2,543,541(-) A/G intron_variant
rs1000005774 -- 2,512,071(-) G/A 3_prime_UTR_variant
rs1000008173 -- 2,656,732(-) C/G intron_variant
rs1000009413 -- 2,664,230(-) G/A intron_variant
rs1000033098 -- 2,650,925(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GNG7 Gene

Variant ID Type Subtype PubMed ID
dgv1688n106 CNV deletion 24896259
dgv6219n54 CNV gain+loss 21841781
dgv6220n54 CNV loss 21841781
dgv6221n54 CNV gain+loss 21841781
dgv6222n54 CNV gain 21841781
dgv6223n54 CNV loss 21841781
dgv6224n54 CNV loss 21841781
dgv6225n54 CNV loss 21841781
esv1406094 CNV insertion 17803354
esv1706865 CNV deletion 17803354
esv2153598 CNV deletion 18987734
esv23824 CNV loss 19812545
esv2444878 CNV deletion 19546169
esv2657598 CNV deletion 23128226
esv2717899 CNV deletion 23290073
esv2717900 CNV deletion 23290073
esv2717901 CNV deletion 23290073
esv2717902 CNV deletion 23290073
esv2717903 CNV deletion 23290073
esv2717904 CNV deletion 23290073
esv2762019 CNV gain 21179565
esv29337 CNV loss 19812545
esv3368818 CNV insertion 20981092
esv3371283 CNV duplication 20981092
esv3555860 CNV deletion 23714750
esv3555863 CNV deletion 23714750
esv3574275 CNV gain 25503493
esv3643429 CNV loss 21293372
esv3643430 CNV loss 21293372
esv3643431 CNV loss 21293372
esv3643432 CNV loss 21293372
esv3643433 CNV loss 21293372
esv3643434 CNV loss 21293372
nsv1056064 CNV loss 25217958
nsv1064930 CNV gain 25217958
nsv1071890 CNV deletion 25765185
nsv1072839 CNV deletion 25765185
nsv1072840 CNV deletion 25765185
nsv1109158 CNV deletion 24896259
nsv1123208 CNV deletion 24896259
nsv1129614 CNV tandem duplication 24896259
nsv1133437 CNV deletion 24896259
nsv1134741 CNV deletion 24896259
nsv1146074 CNV deletion 26484159
nsv458326 CNV gain 19166990
nsv470109 CNV loss 18288195
nsv470111 CNV gain 18288195
nsv509714 CNV insertion 20534489
nsv526820 CNV loss 19592680
nsv578387 CNV gain 21841781
nsv578388 CNV gain+loss 21841781
nsv578390 CNV loss 21841781
nsv578398 CNV gain 21841781
nsv828397 CNV gain 20364138
nsv833708 CNV loss 17160897
nsv953944 CNV deletion 24416366
nsv953945 CNV deletion 24416366
nsv960771 CNV duplication 23825009
nsv978759 CNV duplication 23825009

Variation tolerance for GNG7 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GNG7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG7 Gene

Disorders for GNG7 Gene

Additional Disease Information for GNG7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GNG7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG7 Gene

Publications for GNG7 Gene

  1. Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer. (PMID: 9600093) Shibata K … Akiyoshi T (Biochemical and biophysical research communications 1998) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer. (PMID: 18219292) Ohta M … Mori M (British journal of cancer 2008) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58

Products for GNG7 Gene

  • Addgene plasmids for GNG7

Sources for GNG7 Gene

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