Aliases for PCLO Gene
External Ids for PCLO Gene
Previous GeneCards Identifiers for PCLO Gene
The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for PCLO Gene
PCLO (Piccolo Presynaptic Cytomatrix Protein) is a Protein Coding gene. Diseases associated with PCLO include Pontocerebellar Hypoplasia, Type 3 and Pontocerebellar Hypoplasia. Among its related pathways are Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include calcium ion binding and transporter activity. An important paralog of this gene is BSN.
UniProtKB/Swiss-Prot for PCLO Gene
May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking.