Aliases for GCLC Gene
External Ids for GCLC Gene
Previous HGNC Symbols for GCLC Gene
Previous GeneCards Identifiers for GCLC Gene
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
GeneCards Summary for GCLC Gene
GCLC (Glutamate-Cysteine Ligase Catalytic Subunit) is a Protein Coding gene. Diseases associated with GCLC include Gamma-Glutamylcysteine Synthetase Deficiency, Hemolytic Anemia Due To and Myocardial Infarction. Among its related pathways are Aryl Hydrocarbon Receptor and Glutathione metabolism. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and coenzyme binding.