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Aliases for TINAG Gene

Aliases for TINAG Gene

  • Tubulointerstitial Nephritis Antigen 2 3 3 5
  • TIN-AG 3
  • TIN-Ag 4

External Ids for TINAG Gene

Previous GeneCards Identifiers for TINAG Gene

  • GC06P054175
  • GC06P054220
  • GC06P054006

Summaries for TINAG Gene

Entrez Gene Summary for TINAG Gene

  • This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]

GeneCards Summary for TINAG Gene

TINAG (Tubulointerstitial Nephritis Antigen) is a Protein Coding gene. Diseases associated with TINAG include Membranous Nephropathy. Gene Ontology (GO) annotations related to this gene include nucleotide binding and cysteine-type peptidase activity. An important paralog of this gene is TINAGL1.

UniProtKB/Swiss-Prot for TINAG Gene

  • Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.

Gene Wiki entry for TINAG Gene

Additional gene information for TINAG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TINAG Gene

Genomics for TINAG Gene

GeneHancer (GH) Regulatory Elements for TINAG Gene

Promoters and enhancers for TINAG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J054307 Promoter/Enhancer 1.1 EPDnew ENCODE 650.7 +0.7 669 2.9 SOX13 FOXA2 HLF ETV5 RELA HNF1A POLR3A ETV4 NR2F6 CREM TINAG PIR37965 GC06M054324
GH06J054877 Enhancer 1.2 ENCODE dbSUPER 9.7 +571.1 571073 2.2 PKNOX1 ARNT FEZF1 GLI4 ZNF2 IRF4 YY1 GLIS2 ZNF213 KLF7 ENSG00000224984 ENSG00000228231 FAM83B TINAG GC06P054848 ENSG00000261116
GH06J054335 Enhancer 0.8 Ensembl ENCODE 12.2 +28.3 28340 1.6 STAT1 JUN MAX CEBPB EP300 RFX5 SP1 JUND POLR2A ZNF629 TINAG PIR37965 GC06M054324 ENSG00000228231
GH06J054281 Enhancer 0.4 ENCODE 11.4 -25.4 -25375 1.3 JUND FOSL2 ELF1 TINAG GC06M054286 PIR57485
GH06J054283 Enhancer 0.2 ENCODE 11.4 -23.5 -23477 1.8 TINAG GC06M054286 PIR57485
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TINAG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TINAG gene promoter:
  • POU6F1 (c2)
  • MEF-2A
  • aMEF-2
  • SEF-1 (1)
  • STAT5A
  • YY1
  • Cart-1
  • POU2F1a
  • POU2F1
  • TBP

Genomic Locations for TINAG Gene

Genomic Locations for TINAG Gene
82,361 bases
Plus strand
82,294 bases
Plus strand

Genomic View for TINAG Gene

Genes around TINAG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TINAG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TINAG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TINAG Gene

Proteins for TINAG Gene

  • Protein details for TINAG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulointerstitial nephritis antigen
    Protein Accession:
    Secondary Accessions:
    • Q5T467
    • Q9UJW1
    • Q9ULZ4

    Protein attributes for TINAG Gene

    476 amino acids
    Molecular mass:
    54605 Da
    Quaternary structure:
    No Data Available
    • Antibodies against TINAG are found in sera of patients with tubulointerstitial nephritis, a rare autoimmune disorder that causes acute and chronic renal injury.

    Alternative splice isoforms for TINAG Gene


neXtProt entry for TINAG Gene

Post-translational modifications for TINAG Gene

  • It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
  • Glycosylation at posLast=455455, isoforms=2360, posLast=314314, isoforms=2175, and isoforms=238
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TINAG Gene

Domains & Families for TINAG Gene

Gene Families for TINAG Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TINAG Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C1 family.
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with TINAG: view

Function for TINAG Gene

Molecular function for TINAG Gene

UniProtKB/Swiss-Prot Function:
Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.

Phenotypes From GWAS Catalog for TINAG Gene

Gene Ontology (GO) - Molecular Function for TINAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 10652240
GO:0004197 cysteine-type endopeptidase activity TAS 10652240
GO:0005044 scavenger receptor activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0030247 polysaccharide binding IEA --
genes like me logo Genes that share ontologies with TINAG: view
genes like me logo Genes that share phenotypes with TINAG: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TINAG

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TINAG Gene

Localization for TINAG Gene

Subcellular locations from UniProtKB/Swiss-Prot for TINAG Gene

Secreted, extracellular space, extracellular matrix, basement membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TINAG gene
Compartment Confidence
extracellular 5
lysosome 2
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TINAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005604 basement membrane IEA,IDA 1762287
GO:0005615 extracellular space IBA --
GO:0005764 NOT lysosome IBA --
genes like me logo Genes that share ontologies with TINAG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TINAG Gene

Pathways & Interactions for TINAG Gene

SuperPathways for TINAG Gene

No Data Available

Interacting Proteins for TINAG Gene

Gene Ontology (GO) - Biological Process for TINAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006955 immune response IEA --
GO:0007155 cell adhesion IDA,IEA 8770961
GO:0051603 NOT proteolysis involved in cellular protein catabolic process IBA --
genes like me logo Genes that share ontologies with TINAG: view

No data available for Pathways by source and SIGNOR curated interactions for TINAG Gene

Drugs & Compounds for TINAG Gene

(1) Drugs for TINAG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TINAG: view

Transcripts for TINAG Gene

Unigene Clusters for TINAG Gene

Tubulointerstitial nephritis antigen:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TINAG Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: - -
SP2: - - - -
SP3: - -

Relevant External Links for TINAG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TINAG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TINAG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TINAG Gene

This gene is overexpressed in Kidney - Cortex (x29.6), Colon - Transverse (x12.7), and Small Intestine - Terminal Ileum (x6.4).

Protein differential expression in normal tissues from HIPED for TINAG Gene

This gene is overexpressed in Kidney (62.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TINAG Gene

NURSA nuclear receptor signaling pathways regulating expression of TINAG Gene:


SOURCE GeneReport for Unigene cluster for TINAG Gene:


mRNA Expression by UniProt/SwissProt for TINAG Gene:

Tissue specificity: Expressed in the kidney cortex, small intestine and cornea.

Evidence on tissue expression from TISSUES for TINAG Gene

  • Kidney(4.8)
genes like me logo Genes that share expression patterns with TINAG: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TINAG Gene

Orthologs for TINAG Gene

This gene was present in the common ancestor of animals.

Orthologs for TINAG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TINAG 34 33
  • 99.44 (n)
(Canis familiaris)
Mammalia TINAG 34 33
  • 91.46 (n)
(Bos Taurus)
Mammalia TINAG 34 33
  • 89.15 (n)
(Mus musculus)
Mammalia Tinag 16 34 33
  • 86.81 (n)
(Rattus norvegicus)
Mammalia Tinag 33
  • 86.67 (n)
(Monodelphis domestica)
Mammalia TINAG 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia TINAG 34
  • 65 (a)
(Gallus gallus)
Aves TINAG 34 33
  • 62.6 (n)
(Anolis carolinensis)
Reptilia TINAG 34
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3074 35
  • 39 (a)
Swim 34
  • 37 (a)
(Caenorhabditis elegans)
Secernentea F26E4.3 34 35
  • 36 (a)
Species where no ortholog for TINAG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TINAG Gene

Gene Tree for TINAG (if available)
Gene Tree for TINAG (if available)
Evolutionary constrained regions (ECRs) for TINAG: view image

Paralogs for TINAG Gene

Paralogs for TINAG Gene

(1) SIMAP similar genes for TINAG Gene using alignment to 6 proteins:

  • B1AQ11_HUMAN
  • Q5T466_HUMAN
  • Q5T471_HUMAN
  • Q7Z477_HUMAN
genes like me logo Genes that share paralogs with TINAG: view

Variants for TINAG Gene

Sequence variations from dbSNP and Humsavar for TINAG Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000004946 -- 54,388,683(+) T/C intron_variant
rs1000033785 -- 54,334,214(+) G/T intron_variant
rs1000106711 -- 54,334,528(+) A/G intron_variant
rs1000131525 -- 54,352,202(+) T/C intron_variant
rs1000178297 -- 54,355,625(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TINAG Gene

Variant ID Type Subtype PubMed ID
esv3539751 CNV deletion 23714750
esv3890847 CNV loss 25118596
nsv819178 CNV gain 19587683

Variation tolerance for TINAG Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.41; 88.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TINAG Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TINAG Gene

Disorders for TINAG Gene

MalaCards: The human disease database

(1) MalaCards diseases for TINAG Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
membranous nephropathy
  • membranous nephropathy, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search TINAG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TINAG

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TINAG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TINAG Gene

Publications for TINAG Gene

  1. Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen. (PMID: 10652240) Ikeda M … Yoshioka K (Biochemical and biophysical research communications 2000) 2 3 4 22 58
  2. Identification of two alternatively spliced forms of human tubulointerstitial nephritis antigen (TIN-Ag). (PMID: 10752525) Zhou B … Charonis AS (Journal of the American Society of Nephrology : JASN 2000) 3 4 22 58
  3. Tubulointerstitial nephritis antigen (TIN-ag) is expressed in distinct segments of the developing human nephron. (PMID: 9643646) Nelson TR … Charonis AS (Connective tissue research 1998) 3 4 22 58
  4. REceptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen. (PMID: 8770961) Chen Y … Charonis AS (Kidney international 1996) 3 4 22 58
  5. Role of antibodies to tubulointerstitial nephritis antigen in human anti-tubular basement membrane nephritis associated with membranous nephropathy. (PMID: 1466368) Katz A … Butkowski RJ (The American journal of medicine 1992) 3 4 22 58

Products for TINAG Gene

Sources for TINAG Gene

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