Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNF115 Gene

Aliases for RNF115 Gene

  • Ring Finger Protein 115 2 3 5
  • Zinc Finger Protein 364 2 3 4
  • RING-Type E3 Ubiquitin Transferase RNF115 3 4
  • Rabring 7 3 4
  • ZNF364 3 4
  • E3 Ubiquitin-Protein Ligase RNF115 3
  • RING Finger Protein 115 4
  • EC 4
  • BCA2 3

External Ids for RNF115 Gene

Previous HGNC Symbols for RNF115 Gene

  • ZNF364

Previous GeneCards Identifiers for RNF115 Gene

  • GC01P144323
  • GC01P145611
  • GC01P119574

Summaries for RNF115 Gene

GeneCards Summary for RNF115 Gene

RNF115 (Ring Finger Protein 115) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is RNF126.

UniProtKB/Swiss-Prot for RNF115 Gene

  • E3 ubiquitin-protein ligase that mediates E2-dependent, Lys-48- and/or Lys-63-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.

Gene Wiki entry for RNF115 Gene

Additional gene information for RNF115 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF115 Gene

Genomics for RNF115 Gene

GeneHancer (GH) Regulatory Elements for RNF115 Gene

Promoters and enhancers for RNF115 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J145822 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.2 219 2.6 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 POLR3C RNF115 NBPF20 GPR89A NUDT17 PIAS3 PIR40983
GH01J145773 Promoter 0.5 EPDnew 650.2 +50.3 50270 0.1 RNF115 PIR35710 PIR40983
GH01J145781 Enhancer 1.1 Ensembl ENCODE 0.3 +41.5 41468 2.3 INSM2 RAD21 ZBTB40 RFX5 ZEB1 GTF3C2 POLR3A EGR1 ZNF366 RCOR1 POLR3C NUDT17 PIAS3 NBPF20 GNRHR2 PDZK1 CD160 GPR89A ANKRD35 PIR35710
GH01J145817 Enhancer 0.6 Ensembl ENCODE 0.4 +5.8 5800 0.7 MEF2D IKZF1 MEF2B CD160 POLR3C RNF115 PIR40983
GH01J145785 Enhancer 0.6 Ensembl ENCODE 0.3 +38.0 38041 1.9 PRDM6 RUNX3 PRDM1 POLR3C ANKRD35 PIR35710 PIR40983 RNF115
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF115 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF115 gene promoter:
  • Pax-2a
  • Pax-2
  • FOXO4
  • AREB6
  • S8
  • Sox5
  • Msx-1
  • AML1a
  • deltaCREB
  • CREB

Genomic Locations for RNF115 Gene

Genomic Locations for RNF115 Gene
85,256 bases
Minus strand
85,183 bases
Plus strand

Genomic View for RNF115 Gene

Genes around RNF115 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF115 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF115 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF115 Gene

Proteins for RNF115 Gene

  • Protein details for RNF115 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF115
    Protein Accession:
    Secondary Accessions:
    • A8K3Y4
    • Q5T2V9
    • Q7Z2J2

    Protein attributes for RNF115 Gene

    304 amino acids
    Molecular mass:
    33703 Da
    Quaternary structure:
    • Interacts with RAB7A. Interacts with EGFR and FLT3.

neXtProt entry for RNF115 Gene

Post-translational modifications for RNF115 Gene

  • RING-type zinc finger-dependent and E2-dependent autoubiquitination.
  • Ubiquitination at posLast=3232 and posLast=2626
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF115 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF115 Gene

Domains & Families for RNF115 Gene

Gene Families for RNF115 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for RNF115 Gene


Suggested Antigen Peptide Sequences for RNF115 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF115: view

No data available for UniProtKB/Swiss-Prot for RNF115 Gene

Function for RNF115 Gene

Molecular function for RNF115 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates E2-dependent, Lys-48- and/or Lys-63-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Enzyme Numbers (IUBMB) for RNF115 Gene

Phenotypes From GWAS Catalog for RNF115 Gene

Gene Ontology (GO) - Molecular Function for RNF115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 16925951
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IEA,ISS --
genes like me logo Genes that share ontologies with RNF115: view
genes like me logo Genes that share phenotypes with RNF115: view

Animal Model Products

miRNA for RNF115 Gene

miRTarBase miRNAs that target RNF115

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF115 Gene

Localization for RNF115 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF115 Gene

Cytoplasm, cytosol. Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes. {ECO:0000250 UniProtKB:Q9D0C1}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF115 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2
lysosome 2
extracellular 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA,TAS --
genes like me logo Genes that share ontologies with RNF115: view

Pathways & Interactions for RNF115 Gene

genes like me logo Genes that share pathways with RNF115: view

UniProtKB/Swiss-Prot Q9Y4L5-RN115_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0016567 protein ubiquitination IEA --
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IMP 23418353
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP 23418353
genes like me logo Genes that share ontologies with RNF115: view

No data available for SIGNOR curated interactions for RNF115 Gene

Drugs & Compounds for RNF115 Gene

No Compound Related Data Available

Transcripts for RNF115 Gene

mRNA/cDNA for RNF115 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(127) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF115 Gene

Ring finger protein 115:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF115 Gene

No ASD Table

Relevant External Links for RNF115 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF115 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF115 Gene

Protein differential expression in normal tissues from HIPED for RNF115 Gene

This gene is overexpressed in Bone (47.4), Islet of Langerhans (9.6), and CD8 Tcells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF115 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF115 Gene:


SOURCE GeneReport for Unigene cluster for RNF115 Gene:


mRNA Expression by UniProt/SwissProt for RNF115 Gene:

Tissue specificity: Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells.

Evidence on tissue expression from TISSUES for RNF115 Gene

  • Pancreas(4.2)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with RNF115: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF115 Gene

Orthologs for RNF115 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF115 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF115 33
  • 99.56 (n)
(Canis familiaris)
Mammalia RNF115 33
  • 93.96 (n)
(Bos Taurus)
Mammalia RNF115 33
  • 91.88 (n)
(Mus musculus)
Mammalia Rnf115 16 33
  • 90.9 (n)
(Rattus norvegicus)
Mammalia Rnf115 33
  • 89.78 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf115 33
  • 67.96 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22142 33
(Danio rerio)
Actinopterygii rnf115 33
  • 65.56 (n)
Dr.15141 33
Species where no ortholog for RNF115 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF115 Gene

Gene Tree for RNF115 (if available)
Gene Tree for RNF115 (if available)
Evolutionary constrained regions (ECRs) for RNF115: view image

Paralogs for RNF115 Gene

Paralogs for RNF115 Gene

(2) SIMAP similar genes for RNF115 Gene using alignment to 3 proteins:

  • RN115_HUMAN
  • F5H4I2_HUMAN
  • H0YG75_HUMAN
genes like me logo Genes that share paralogs with RNF115: view

Variants for RNF115 Gene

Sequence variations from dbSNP and Humsavar for RNF115 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000066364 -- 145,771,388(-) A/G intron_variant
rs1000073992 -- 145,823,949(-) T/G 5_prime_UTR_variant, non_coding_transcript_variant
rs1000128423 -- 145,764,728(-) G/A intron_variant
rs1000157536 -- 145,748,508(-) C/T intron_variant
rs1000205868 -- 145,765,497(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF115 Gene

Variant ID Type Subtype PubMed ID
dgv331n100 CNV gain 25217958
dgv332n100 CNV gain+loss 25217958
dgv33n27 CNV loss 19166990
dgv531n54 CNV loss 21841781
dgv532n54 CNV gain 21841781
dgv533n54 CNV gain 21841781
dgv95e212 CNV gain 25503493
esv2669179 CNV deletion 23128226
esv3572342 CNV gain 25503493
esv3587421 CNV loss 21293372
esv3587422 CNV gain 21293372
esv3587423 CNV loss 21293372
esv3894089 CNV loss 25118596
nsv1005055 CNV loss 25217958
nsv1015025 CNV gain 25217958
nsv1113171 CNV deletion 24896259
nsv1144400 CNV deletion 24896259
nsv1161499 CNV duplication 26073780
nsv463483 CNV loss 19166990
nsv463494 CNV gain 19166990
nsv469752 CNV loss 16826518
nsv470735 CNV gain 18288195
nsv547662 CNV loss 21841781
nsv547665 CNV gain+loss 21841781
nsv547670 CNV loss 21841781
nsv547671 CNV loss 21841781
nsv818411 CNV loss 17921354
nsv831381 CNV gain 17160897
nsv831392 CNV gain 17160897
nsv946266 CNV duplication 23825009
nsv950949 CNV duplication 24416366
nsv998178 CNV loss 25217958

Variation tolerance for RNF115 Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 25.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF115 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF115 Gene

Disorders for RNF115 Gene

Additional Disease Information for RNF115

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RNF115 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF115 Gene

Publications for RNF115 Gene

  1. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. (PMID: 23418353) Smith CJ … McGlade CJ (Journal of cell science 2013) 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration. (PMID: 18819927) Amemiya Y … Seth A (Molecular cancer research : MCR 2008) 3 4 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. Novel RING E3 ubiquitin ligases in breast cancer. (PMID: 16925951) Burger A … Seth AK (Neoplasia (New York, N.Y.) 2006) 3 4 58

Products for RNF115 Gene

Sources for RNF115 Gene

Loading form....