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Aliases for ARFIP1 Gene

Aliases for ARFIP1 Gene

  • ADP Ribosylation Factor Interacting Protein 1 2 3 5
  • ADP-Ribosylation Factor-Interacting Protein 1 4
  • Arfaptin-1 3
  • Arfaptin 1 2
  • HSU52521 3

External Ids for ARFIP1 Gene

Previous GeneCards Identifiers for ARFIP1 Gene

  • GC04P154167
  • GC04P154278
  • GC04P154058
  • GC04P153920
  • GC04P153701
  • GC04P149427
  • GC04P152687

Summaries for ARFIP1 Gene

GeneCards Summary for ARFIP1 Gene

ARFIP1 (ADP Ribosylation Factor Interacting Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and phosphatidylinositol-4-phosphate binding. An important paralog of this gene is ARFIP2.

UniProtKB/Swiss-Prot for ARFIP1 Gene

  • Putative target protein of ADP-ribosylation factor.

Gene Wiki entry for ARFIP1 Gene

Additional gene information for ARFIP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARFIP1 Gene

Genomics for ARFIP1 Gene

GeneHancer (GH) Regulatory Elements for ARFIP1 Gene

Promoters and enhancers for ARFIP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J152778 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 720.4 +0.0 9 2.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ARFIP1 TIGD4 GC04M152775 MIR4453HG GC04M152797
GH04J152934 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29.4 +156.9 156863 4.1 SIN3A ZNF2 TCF12 GLIS2 ZNF143 ATF7 ZNF202 SP3 SP5 REST FHDC1 LOC729870 ARFIP1 MIR4453HG TRIM2 FAM192BP
GH04J153218 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 40.9 +441.5 441473 6.4 FOXA2 SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF213 ZNF548 FOS SP3 ARFIP1 TRIM2 MIR4453HG RNU6-1196P ENSG00000201786 TIGD4 MND1 RNF175 GC04M153170 LOC105377496
GH04J153151 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 11.2 +373.3 373270 3.1 SIN3A FEZF1 GLI4 GLIS2 ZNF213 SP3 ATF4 GLIS1 MYNN PRDM4 TRIM2 GC04M153152 ARFIP1 MND1 ENSG00000201786 RNU6-1196P
GH04J152942 Enhancer 0.6 ENCODE dbSUPER 36 +164.1 164124 2.5 NR2F2 EGR2 GC04P152943 GC04P152944 GC04P152945 GC04P152946 ARFIP1 PIR52121 FHDC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARFIP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARFIP1 gene promoter:
  • FOXD3
  • Chx10
  • MEF-2A
  • aMEF-2
  • STAT1
  • HSF2
  • STAT1alpha
  • STAT1beta
  • XBP-1
  • HFH-1

Genomic Locations for ARFIP1 Gene

Genomic Locations for ARFIP1 Gene
138,527 bases
Plus strand
138,527 bases
Plus strand

Genomic View for ARFIP1 Gene

Genes around ARFIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARFIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARFIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARFIP1 Gene

Proteins for ARFIP1 Gene

  • Protein details for ARFIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DS69
    • Q2M2X4
    • Q3SYL4
    • Q9Y2X6

    Protein attributes for ARFIP1 Gene

    373 amino acids
    Molecular mass:
    41738 Da
    Quaternary structure:
    • Interacts with non-myristoylated GTP-bound ARF3, but not to GDP-bound ARF3, and also to ARF1. Binds with lower affinity to ARF5 and with very little affinity to ARF6.

    Alternative splice isoforms for ARFIP1 Gene


neXtProt entry for ARFIP1 Gene

Post-translational modifications for ARFIP1 Gene

  • Ubiquitination at Lys353
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARFIP1 Gene

Domains & Families for ARFIP1 Gene

Gene Families for ARFIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARFIP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARFIP1: view

No data available for UniProtKB/Swiss-Prot for ARFIP1 Gene

Function for ARFIP1 Gene

Molecular function for ARFIP1 Gene

UniProtKB/Swiss-Prot Function:
Putative target protein of ADP-ribosylation factor.

Gene Ontology (GO) - Molecular Function for ARFIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005543 phospholipid binding IBA --
GO:0019904 protein domain specific binding IEA --
GO:0045296 cadherin binding IDA 25468996
GO:0070273 phosphatidylinositol-4-phosphate binding IDA 23695357
genes like me logo Genes that share ontologies with ARFIP1: view
genes like me logo Genes that share phenotypes with ARFIP1: view

Animal Model Products

CRISPR Products

miRNA for ARFIP1 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARFIP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARFIP1 Gene

Localization for ARFIP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARFIP1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Vesicles (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARFIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 9038142
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA 9038142
GO:0032588 trans-Golgi network membrane IDA 23695357
genes like me logo Genes that share ontologies with ARFIP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARFIP1 Gene

Pathways & Interactions for ARFIP1 Gene

SuperPathways for ARFIP1 Gene

No Data Available

SIGNOR curated interactions for ARFIP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ARFIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IDA 12606037
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation IBA --
GO:0050708 regulation of protein secretion IDA 12606037
genes like me logo Genes that share ontologies with ARFIP1: view

No data available for Pathways by source for ARFIP1 Gene

Drugs & Compounds for ARFIP1 Gene

(1) Drugs for ARFIP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARFIP1: view

Transcripts for ARFIP1 Gene

Unigene Clusters for ARFIP1 Gene

ADP-ribosylation factor interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARFIP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARFIP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c · 13d · 13e ^ 14 ^ 15 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP9: - - - - - - - - - -
SP10: - -
SP11: -
SP13: - - - - - -
SP14: - - - - -

ExUns: 16 ^ 17 ^ 18a · 18b · 18c · 18d
SP1: -
SP2: -
SP3: -
SP12: -

Relevant External Links for ARFIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARFIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARFIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARFIP1 Gene

This gene is overexpressed in Nasal epithelium (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARFIP1 Gene

Protein tissue co-expression partners for ARFIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARFIP1 Gene:


SOURCE GeneReport for Unigene cluster for ARFIP1 Gene:


mRNA Expression by UniProt/SwissProt for ARFIP1 Gene:

Tissue specificity: Ubiquitously expressed. Higher levels in liver, pancreas, placenta, skeletal muscle and heart.

Evidence on tissue expression from TISSUES for ARFIP1 Gene

  • Nervous system(4.7)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ARFIP1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARFIP1 Gene

Orthologs for ARFIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARFIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARFIP1 34 33
  • 100 (n)
(Canis familiaris)
Mammalia ARFIP1 34 33
  • 95.26 (n)
(Bos Taurus)
Mammalia ARFIP1 34 33
  • 94.64 (n)
(Monodelphis domestica)
Mammalia ARFIP1 34
  • 93 (a)
(Rattus norvegicus)
Mammalia Arfip1 33
  • 90.71 (n)
(Mus musculus)
Mammalia Arfip1 16 34 33
  • 89.81 (n)
(Ornithorhynchus anatinus)
Mammalia ARFIP1 34
  • 83 (a)
(Gallus gallus)
Aves ARFIP1 34 33
  • 84.19 (n)
(Anolis carolinensis)
Reptilia ARFIP1 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arfip1 33
  • 77.78 (n)
Str.19914 33
African clawed frog
(Xenopus laevis)
Amphibia loc60382-prov 33
(Danio rerio)
Actinopterygii arfip1 34 33
  • 68.34 (n)
idibd2077 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1457 33
fruit fly
(Drosophila melanogaster)
Insecta CG17184 34
  • 44 (a)
(Caenorhabditis elegans)
Secernentea F54C8.7 34
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9407 34
  • 58 (a)
Cin.5370 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5370 33
Species where no ortholog for ARFIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARFIP1 Gene

Gene Tree for ARFIP1 (if available)
Gene Tree for ARFIP1 (if available)
Evolutionary constrained regions (ECRs) for ARFIP1: view image

Paralogs for ARFIP1 Gene

Paralogs for ARFIP1 Gene

(1) SIMAP similar genes for ARFIP1 Gene using alignment to 3 proteins:

  • B4DS69_HUMAN
  • B4E273_HUMAN
genes like me logo Genes that share paralogs with ARFIP1: view

Variants for ARFIP1 Gene

Sequence variations from dbSNP and Humsavar for ARFIP1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000014776 -- 152,891,789(+) A/G intron_variant
rs1000018955 -- 152,824,293(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000037858 -- 152,803,689(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000044015 -- 152,904,760(+) G/C intron_variant
rs1000063526 -- 152,805,626(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARFIP1 Gene

Variant ID Type Subtype PubMed ID
esv2763399 CNV gain 21179565
esv3602715 CNV loss 21293372
nsv1136914 CNV deletion 24896259
nsv516652 CNV loss 19592680
nsv520249 CNV loss 19592680
nsv522511 CNV loss 19592680
nsv830117 CNV gain 17160897
nsv980266 CNV duplication 23825009

Variation tolerance for ARFIP1 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARFIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARFIP1 Gene

Disorders for ARFIP1 Gene

Additional Disease Information for ARFIP1

No disorders were found for ARFIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARFIP1 Gene

Publications for ARFIP1 Gene

  1. Arfaptin 1 forms a complex with ADP-ribosylation factor and inhibits phospholipase D. (PMID: 10413101) Williger BT … Exton JH (FEBS letters 1999) 2 3 4 22 58
  2. Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. (PMID: 9038142) Kanoh H … Exton JH (The Journal of biological chemistry 1997) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in HT 1080 fibrosarcoma cells. (PMID: 12606037) Ho WT … Williger BT (FEBS letters 2003) 3 22 58

Products for ARFIP1 Gene

Sources for ARFIP1 Gene

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