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Aliases for IL36B Gene

Aliases for IL36B Gene

  • Interleukin 36 Beta 2 3 5
  • Interleukin 1 Family, Member 8 (Eta) 2 3
  • Interleukin-1 Family Member 8 3 4
  • Interleukin-1 Homolog 2 3 4
  • Interleukin-1 Eta 3 4
  • FIL1 Eta 3 4
  • IL-1 Eta 3 4
  • IL-1F8 3 4
  • IL-1H2 3 4
  • IL1F8 3 4
  • IL1H2 3 4
  • IL1F8 (Canonical Product IL-1F8a) 3
  • Interleukin-1 Superfamily E 3
  • Family Of Interleukin 1-Eta 3
  • Interleukin-36 Beta 3
  • IL-1F8 (FIL1-Eta) 3
  • FIL1-(ETA) 3
  • FILI-(ETA) 3
  • IL1-ETA 3
  • FIL1H 3
  • FIL1 3

External Ids for IL36B Gene

Previous HGNC Symbols for IL36B Gene

  • IL1F8

Previous GeneCards Identifiers for IL36B Gene

  • GC02M113779

Summaries for IL36B Gene

Entrez Gene Summary for IL36B Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL36B Gene

IL36B (Interleukin 36 Beta) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-1 receptor binding. An important paralog of this gene is IL36A.

UniProtKB/Swiss-Prot for IL36B Gene

  • Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.

Gene Wiki entry for IL36B Gene

Additional gene information for IL36B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL36B Gene

Genomics for IL36B Gene

GeneHancer (GH) Regulatory Elements for IL36B Gene

Promoters and enhancers for IL36B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J113054 Enhancer 0.3 FANTOM5 672.8 -1.4 -1414 0.4 IL36B IL1RN IL1B IL36G IL1A IL36RN
GH02J113053 Enhancer 0.2 ENCODE 681.1 -0.4 -375 1.2 IL36B IL36RN PSD4
GH02J113052 Enhancer 0.2 ENCODE 650.7 +0.3 348 0.2 IL36B IL36A
GH02J113076 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 50.2 -25.9 -25935 3.7 NFIB RAD21 RFX5 YY1 ZNF143 FOS RCOR1 EGR2 ZNF654 RXRA IL1RN IL36B IL1B IL36A IL36RN PSD4 IL36G IL37 PAX8-AS1 IL1A
GH02J113123 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 28.9 -72.1 -72117 3.2 PKNOX1 MLX FOS RUNX3 JUNB REST KAT8 SREBF1 NFIL3 SSRP1 IL1RN IL36B PSD4 IL1B RNU6-1180P PAX8-AS1 PAX8 IL1F10 IL36G IL1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL36B on UCSC Golden Path with GeneCards custom track

Genomic Locations for IL36B Gene

Genomic Locations for IL36B Gene
chr2:113,022,091-113,052,867
(GRCh38/hg38)
Size:
30,777 bases
Orientation:
Minus strand
chr2:113,779,668-113,810,444
(GRCh37/hg19)
Size:
30,777 bases
Orientation:
Minus strand

Genomic View for IL36B Gene

Genes around IL36B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL36B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL36B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL36B Gene

Proteins for IL36B Gene

  • Protein details for IL36B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZH7-IL36B_HUMAN
    Recommended name:
    Interleukin-36 beta
    Protein Accession:
    Q9NZH7
    Secondary Accessions:
    • Q3MIH0
    • Q53SR6
    • Q7RTZ7
    • Q9UHA5

    Protein attributes for IL36B Gene

    Size:
    164 amino acids
    Molecular mass:
    18522 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IL36B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL36B Gene

Post-translational modifications for IL36B Gene

  • N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL36B Gene

Antibody Products

  • R&D Systems Antibodies for IL36B (IL-36 beta/IL-1F8)
  • Boster Bio Antibodies for IL36B

No data available for DME Specific Peptides for IL36B Gene

Domains & Families for IL36B Gene

Gene Families for IL36B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IL36B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL36B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZH7

UniProtKB/Swiss-Prot:

IL36B_HUMAN :
  • Belongs to the IL-1 family.
Family:
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL36B: view

Function for IL36B Gene

Molecular function for IL36B Gene

UniProtKB/Swiss-Prot Function:
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.
UniProtKB/Swiss-Prot Induction:
By proinflammatory cytokines IL1A, IL1B and TNF in synovial fibroblasts. By IL1A and TNF in keratinocytes. Constitutive in articular chondrocytes.

Phenotypes From GWAS Catalog for IL36B Gene

Gene Ontology (GO) - Molecular Function for IL36B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005149 interleukin-1 receptor binding TAS,NAS 10744718
genes like me logo Genes that share ontologies with IL36B: view
genes like me logo Genes that share phenotypes with IL36B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IL36B

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL36B

Clone Products

  • R&D Systems cDNA Clones for IL36B (IL-36 beta/IL-1F8)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL36B Gene

Localization for IL36B Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL36B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL36B gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for IL36B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10744718
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IL36B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL36B Gene

Pathways & Interactions for IL36B Gene

genes like me logo Genes that share pathways with IL36B: view

Pathways by source for IL36B Gene

1 R&D Systems pathway for IL36B Gene

Interacting Proteins for IL36B Gene

Gene Ontology (GO) - Biological Process for IL36B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0006955 immune response NAS 10744718
GO:0010469 regulation of signaling receptor activity IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with IL36B: view

No data available for SIGNOR curated interactions for IL36B Gene

Drugs & Compounds for IL36B Gene

No Compound Related Data Available

Transcripts for IL36B Gene

mRNA/cDNA for IL36B Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL36B Gene

Interleukin 36, beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL36B

Clone Products

  • R&D Systems cDNA Clones for IL36B (IL-36 beta/IL-1F8)

Alternative Splicing Database (ASD) splice patterns (SP) for IL36B Gene

No ASD Table

Relevant External Links for IL36B Gene

GeneLoc Exon Structure for
IL36B
ECgene alternative splicing isoforms for
IL36B

Expression for IL36B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL36B Gene

mRNA differential expression in normal tissues according to GTEx for IL36B Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x25.3), Skin - Not Sun Exposed (Suprapubic) (x15.2), and Esophagus - Mucosa (x7.6).

NURSA nuclear receptor signaling pathways regulating expression of IL36B Gene:

IL36B

SOURCE GeneReport for Unigene cluster for IL36B Gene:

Hs.278909

mRNA Expression by UniProt/SwissProt for IL36B Gene:

Q9NZH7-IL36B_HUMAN
Tissue specificity: Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue.

Evidence on tissue expression from TISSUES for IL36B Gene

  • Lung(4)
genes like me logo Genes that share expression patterns with IL36B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL36B Gene

Orthologs for IL36B Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL36B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC483068 33
  • 78.29 (n)
IL36B 34
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il36b 33
  • 78.21 (n)
cow
(Bos Taurus)
Mammalia LOC100297786 33
  • 74.12 (n)
IL36B 34
  • 31 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il1f8 16 34 33
  • 73.42 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 25 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 23 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 16 (a)
ManyToMany
-- 34
  • 15 (a)
ManyToMany
-- 34
  • 15 (a)
ManyToMany
-- 34
  • 13 (a)
ManyToMany
Species where no ortholog for IL36B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL36B Gene

ENSEMBL:
Gene Tree for IL36B (if available)
TreeFam:
Gene Tree for IL36B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL36B: view image

Paralogs for IL36B Gene

Paralogs for IL36B Gene

(2) SIMAP similar genes for IL36B Gene using alignment to 1 proteins:

  • IL36B_HUMAN
genes like me logo Genes that share paralogs with IL36B: view

Variants for IL36B Gene

Sequence variations from dbSNP and Humsavar for IL36B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000119218 -- 113,039,350(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000170594 -- 113,044,092(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000195479 -- 113,036,234(-) C/A/T genic_upstream_transcript_variant, intron_variant
rs1000247614 -- 113,042,593(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000264006 -- 113,044,370(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IL36B Gene

Variant ID Type Subtype PubMed ID
esv3369496 CNV insertion 20981092
nsv2881 CNV deletion 18451855
nsv582709 CNV loss 21841781

Variation tolerance for IL36B Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL36B Gene

Human Gene Mutation Database (HGMD)
IL36B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL36B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL36B Gene

Disorders for IL36B Gene

Additional Disease Information for IL36B

No disorders were found for IL36B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL36B Gene

Publications for IL36B Gene

  1. Four new members expand the interleukin-1 superfamily. (PMID: 10625660) Smith DE … Sims JE (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. (PMID: 16646978) Magne D … Gabay C (Arthritis research & therapy 2006) 2 3 4 58
  3. IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin. (PMID: 24829417) Foster AM … Johnston A (Journal of immunology (Baltimore, Md. : 1950) 2014) 3 4 58
  4. IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression. (PMID: 21242515) Johnston A … Gudjonsson JE (Journal of immunology (Baltimore, Md. : 1950) 2011) 3 4 58
  5. Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity. (PMID: 21965679) Towne JE … Sims JE (The Journal of biological chemistry 2011) 3 4 58

Products for IL36B Gene

Sources for IL36B Gene

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