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Aliases for ZBTB11 Gene

Aliases for ZBTB11 Gene

  • Zinc Finger And BTB Domain Containing 11 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 11 3
  • ZNF-U69274 3
  • ZNF913 3

External Ids for ZBTB11 Gene

Previous GeneCards Identifiers for ZBTB11 Gene

  • GC03M102690
  • GC03M102850
  • GC03M101367
  • GC03M098737

Summaries for ZBTB11 Gene

GeneCards Summary for ZBTB11 Gene

ZBTB11 (Zinc Finger And BTB Domain Containing 11) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZBTB11 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZBTB11 Gene

Additional gene information for ZBTB11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB11 Gene

Genomics for ZBTB11 Gene

GeneHancer (GH) Regulatory Elements for ZBTB11 Gene

Promoters and enhancers for ZBTB11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J101674 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 680.5 +0.8 775 3.7 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 E2F8 ZBTB11 ZBTB11-AS1 NXPE3 SENP7
GH03J101683 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 16.4 -8.3 -8309 5.2 PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 YY1 RPL24 LOC105374013 GC03P101686 ZBTB11-AS1 SENP7 RPS18P5 ZNF90P1 ZBTB11 TFG PDCL3P4
GH03J101511 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.7 +164.8 164765 3.3 HDGF PKNOX1 ARID4B SIN3A ZBTB7B YY1 ZNF143 SP3 SP5 REST SENP7 ZBTB11 ZBTB11-AS1 NXPE3 GC03M101474
GH03J101572 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.8 +103.1 103083 3.4 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 PCNP NXPE3 SENP7 ZBTB11-AS1 ZBTB11 RPS18P5
GH03J101720 Enhancer 1 Ensembl ENCODE 22.3 -44.3 -44325 2.4 RB1 STAT5A IRF4 NCOA2 ZNF143 ETV6 BCLAF1 IKZF2 RUNX3 CREM GC03P101720 GC03P101721 NXPE3 ZBTB11-AS1 ZBTB11 SENP7 RPL24 CEP97
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB11 gene promoter:
  • POU2F1a
  • POU2F1
  • CREB
  • HTF
  • GATA-2
  • AML1a
  • POU3F1
  • ATF-2
  • Ik-2
  • GR-alpha

Genomic Locations for ZBTB11 Gene

Genomic Locations for ZBTB11 Gene
chr3:101,648,889-101,677,495
(GRCh38/hg38)
Size:
28,607 bases
Orientation:
Minus strand
chr3:101,367,733-101,396,339
(GRCh37/hg19)
Size:
28,607 bases
Orientation:
Minus strand

Genomic View for ZBTB11 Gene

Genes around ZBTB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB11 Gene

Proteins for ZBTB11 Gene

  • Protein details for ZBTB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95625-ZBT11_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 11
    Protein Accession:
    O95625
    Secondary Accessions:
    • Q2NKP9

    Protein attributes for ZBTB11 Gene

    Size:
    1053 amino acids
    Molecular mass:
    119384 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB11 Gene

Post-translational modifications for ZBTB11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB11 Gene

No data available for DME Specific Peptides for ZBTB11 Gene

Domains & Families for ZBTB11 Gene

Gene Families for ZBTB11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transcription factors

Protein Domains for ZBTB11 Gene

Suggested Antigen Peptide Sequences for ZBTB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB11: view

No data available for UniProtKB/Swiss-Prot for ZBTB11 Gene

Function for ZBTB11 Gene

Molecular function for ZBTB11 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ZBTB11: view
genes like me logo Genes that share phenotypes with ZBTB11: view

Animal Model Products

miRNA for ZBTB11 Gene

miRTarBase miRNAs that target ZBTB11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB11 Gene

Localization for ZBTB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB11 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZBTB11: view

Pathways & Interactions for ZBTB11 Gene

SuperPathways for ZBTB11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZBTB11: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB11 Gene

Drugs & Compounds for ZBTB11 Gene

No Compound Related Data Available

Transcripts for ZBTB11 Gene

mRNA/cDNA for ZBTB11 Gene

Unigene Clusters for ZBTB11 Gene

Zinc finger and BTB domain containing 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB11 Gene

No ASD Table

Relevant External Links for ZBTB11 Gene

GeneLoc Exon Structure for
ZBTB11
ECgene alternative splicing isoforms for
ZBTB11

Expression for ZBTB11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB11 Gene

Protein differential expression in normal tissues from HIPED for ZBTB11 Gene

This gene is overexpressed in Serum (59.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBTB11 Gene



Protein tissue co-expression partners for ZBTB11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB11 Gene:

ZBTB11

SOURCE GeneReport for Unigene cluster for ZBTB11 Gene:

Hs.655286
genes like me logo Genes that share expression patterns with ZBTB11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB11 Gene

Orthologs for ZBTB11 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBTB11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB11 34 33
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB11 34 33
  • 91.36 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB11 34 33
  • 91.25 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl24 34
  • 89 (a)
OneToOne
Zbtb11 16 33
  • 87.08 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb11 33
  • 85.84 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB11 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB11 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB11 34 33
  • 72.2 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB11 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb11 33
  • 70.2 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-98p3.1 33
  • 62.45 (n)
ZBTB11 34
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CkIIalpha-i1 34
  • 27 (a)
OneToOne
Species where no ortholog for ZBTB11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB11 Gene

ENSEMBL:
Gene Tree for ZBTB11 (if available)
TreeFam:
Gene Tree for ZBTB11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB11: view image

Paralogs for ZBTB11 Gene

(2) SIMAP similar genes for ZBTB11 Gene using alignment to 3 proteins:

  • ZBT11_HUMAN
  • C9J2L2_HUMAN
  • L8E8H7_HUMAN
genes like me logo Genes that share paralogs with ZBTB11: view

No data available for Paralogs for ZBTB11 Gene

Variants for ZBTB11 Gene

Sequence variations from dbSNP and Humsavar for ZBTB11 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000083406 -- 101,675,936(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000097668 -- 101,666,497(-) C/T 5_prime_UTR_variant, intron_variant
rs1000202168 -- 101,675,494(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000206619 -- 101,672,068(-) C/T coding_sequence_variant, genic_upstream_transcript_variant, synonymous_variant
rs1000251650 -- 101,663,185(-) G/A/C intron_variant

Variation tolerance for ZBTB11 Gene

Residual Variation Intolerance Score: 5.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB11 Gene

Disorders for ZBTB11 Gene

Additional Disease Information for ZBTB11

No disorders were found for ZBTB11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB11 Gene

Publications for ZBTB11 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for ZBTB11 Gene

Sources for ZBTB11 Gene

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