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Aliases for TSPAN13 Gene

Aliases for TSPAN13 Gene

  • Tetraspanin 13 2 3 5
  • Transmembrane 4 Superfamily Member 13 2 3 4
  • Tetraspan NET-6 3 4
  • Tspan-13 3 4
  • TM4SF13 3 4
  • NET6 3 4
  • Transmembrane 4 Superfamily Member Tetraspan NET-6 3
  • Tetraspanin-13 3
  • NET-6 3

External Ids for TSPAN13 Gene

Previous HGNC Symbols for TSPAN13 Gene

  • TM4SF13

Previous GeneCards Identifiers for TSPAN13 Gene

  • GC07P016567

Summaries for TSPAN13 Gene

Entrez Gene Summary for TSPAN13 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN13 Gene

TSPAN13 (Tetraspanin 13) is a Protein Coding gene. An important paralog of this gene is TSPAN31.

Gene Wiki entry for TSPAN13 Gene

Additional gene information for TSPAN13 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN13 Gene

Genomics for TSPAN13 Gene

GeneHancer (GH) Regulatory Elements for TSPAN13 Gene

Promoters and enhancers for TSPAN13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J016753 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 661.3 +1.6 1595 4.2 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF48 YY1 TCF12 ZNF766 GLIS2 TSPAN13 AGR2
GH07J016801 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 11.5 +50.5 50464 6 CLOCK FOXA2 NFIB SIN3A RAD21 RFX5 ZNF143 FOS ZNF654 CEBPB AGR2 AGR3 TSPAN13 LOC100287613
GH07J016666 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.6 -84.7 -84658 4.2 ATF1 ARNT NEUROD1 SIN3A BRCA1 ZNF766 GATA2 ATF7 FOS DEK BZW2 ANKMY2 TSPAN13 ENSG00000235837
GH07J016656 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.6 -95.5 -95493 2.7 PKNOX1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 ATF7 NCOA1 ZNF592 TSPAN13 BZW2 ENSG00000235837
GH07J016878 Promoter/Enhancer 1.2 EPDnew ENCODE 10.4 +127.1 127124 4.4 NCOA3 NEUROD1 NFXL1 BMI1 CTBP1 GATA3 ZNF366 RFX1 DPF2 NR2F2 AGR3 AGR2 TSPAN13 RAD17P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSPAN13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSPAN13 gene promoter:
  • NCX
  • AREB6
  • FOXO4
  • AML1a
  • SEF-1 (1)
  • GATA-1
  • Sp1
  • Max1
  • c-Myc
  • USF-1

Genomic Locations for TSPAN13 Gene

Genomic Locations for TSPAN13 Gene
31,002 bases
Plus strand
31,002 bases
Plus strand

Genomic View for TSPAN13 Gene

Genes around TSPAN13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN13 Gene

Proteins for TSPAN13 Gene

  • Protein details for TSPAN13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for TSPAN13 Gene

    204 amino acids
    Molecular mass:
    22147 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN13 Gene

Post-translational modifications for TSPAN13 Gene

  • Glycosylation at isoforms=137 and posLast=113113
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPAN13 Gene

Domains & Families for TSPAN13 Gene

Gene Families for TSPAN13 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TSPAN13 Gene

Suggested Antigen Peptide Sequences for TSPAN13 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN13: view

Function for TSPAN13 Gene

Phenotypes From GWAS Catalog for TSPAN13 Gene

Gene Ontology (GO) - Molecular Function for TSPAN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005246 calcium channel regulator activity IBA --
genes like me logo Genes that share ontologies with TSPAN13: view
genes like me logo Genes that share phenotypes with TSPAN13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN13

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN13 Gene

Localization for TSPAN13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN13 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TSPAN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 10719184
GO:0016020 membrane TAS 10719184
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN13: view

Pathways & Interactions for TSPAN13 Gene

SuperPathways for TSPAN13 Gene

No Data Available

Interacting Proteins for TSPAN13 Gene

Gene Ontology (GO) - Biological Process for TSPAN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0065009 regulation of molecular function IEA --
GO:1903169 regulation of calcium ion transmembrane transport IEA,IBA --
genes like me logo Genes that share ontologies with TSPAN13: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN13 Gene

Drugs & Compounds for TSPAN13 Gene

No Compound Related Data Available

Transcripts for TSPAN13 Gene

mRNA/cDNA for TSPAN13 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(372) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSPAN13 Gene

Tetraspanin 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN13 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP2: - -

Relevant External Links for TSPAN13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSPAN13 Gene

This gene is overexpressed in Islet of Langerhans (25.3), Pancreas (11.4), Breast (8.4), and Oral epithelium (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TSPAN13 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSPAN13 Gene:


SOURCE GeneReport for Unigene cluster for TSPAN13 Gene:


Evidence on tissue expression from TISSUES for TSPAN13 Gene

  • Nervous system(4.8)
  • Intestine(4.3)
  • Stomach(4.3)
  • Kidney(4.1)
  • Lung(3.5)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with TSPAN13: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN13 Gene

Orthologs for TSPAN13 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN13 34 33
  • 99.84 (n)
(Canis familiaris)
Mammalia TSPAN13 34 33
  • 91.34 (n)
(Bos Taurus)
Mammalia TSPAN13 34 33
  • 90.52 (n)
(Rattus norvegicus)
Mammalia Tspan13 33
  • 89.22 (n)
(Mus musculus)
Mammalia Tspan13 16 34 33
  • 87.91 (n)
(Ornithorhynchus anatinus)
Mammalia TSPAN13 34
  • 66 (a)
(Monodelphis domestica)
Mammalia TSPAN13 34
  • 42 (a)
(Gallus gallus)
Aves TSPAN13 34 33
  • 78.82 (n)
(Anolis carolinensis)
Reptilia TSPAN13 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan13 33
  • 72.31 (n)
MGC76122 33
(Danio rerio)
Actinopterygii tspan13b 34 33
  • 68.31 (n)
tspan13a 34
  • 58 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14088 33
fruit fly
(Drosophila melanogaster)
Insecta Tsp97E 34 33
  • 53.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10763 34
  • 40 (a)
Species where no ortholog for TSPAN13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN13 Gene

Gene Tree for TSPAN13 (if available)
Gene Tree for TSPAN13 (if available)
Evolutionary constrained regions (ECRs) for TSPAN13: view image

Paralogs for TSPAN13 Gene

Paralogs for TSPAN13 Gene

(2) SIMAP similar genes for TSPAN13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TSPAN13: view

Variants for TSPAN13 Gene

Sequence variations from dbSNP and Humsavar for TSPAN13 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000120794 -- 16,754,991(+) T/C intron_variant
rs1000136546 -- 16,773,486(+) A/G intron_variant
rs1000208927 -- 16,763,105(+) T/A intron_variant
rs1000289772 -- 16,751,856(+) T/C upstream_transcript_variant
rs1000297476 -- 16,773,216(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN13 Gene

Variant ID Type Subtype PubMed ID
dgv6289n100 CNV gain 25217958
esv2677204 CNV deletion 23128226
esv3612404 CNV loss 21293372
nsv1028125 CNV gain 25217958
nsv520554 CNV loss 19592680
nsv824019 CNV loss 20364138

Variation tolerance for TSPAN13 Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSPAN13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN13 Gene

Disorders for TSPAN13 Gene

Additional Disease Information for TSPAN13

No disorders were found for TSPAN13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN13 Gene

Publications for TSPAN13 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu RM … Chen JL (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 58
  4. [EXPRESSION OF PFKFB, HK2, NAMPT, TSPAN13 AND HSPB8 GENES IN PEDIATRIC GLIOMA]. (PMID: 27491149) Minchenko DO … Minchenko OH (Likars'ka sprava 2015) 3 58
  5. Urinary Nucleic Acid TSPAN13-to-S100A9 Ratio as a Diagnostic Marker in Prostate Cancer. (PMID: 26713053) Yan C … Kim WJ (Journal of Korean medical science 2015) 3 58

Products for TSPAN13 Gene

Sources for TSPAN13 Gene

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