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Aliases for SEC22A Gene

Aliases for SEC22A Gene

  • SEC22 Homolog A, Vesicle Trafficking Protein 2 3 5
  • SEC22L2 3 4
  • SEC22 Vesicle Trafficking Protein Homolog A (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein-Like 2 (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein Homolog A 3
  • SEC22 Vesicle-Trafficking Protein Homolog A 4
  • SEC22 Vesicle Trafficking Protein-Like 2 3
  • SEC22 Vesicle-Trafficking Protein-Like 2 4
  • Vesicle-Trafficking Protein SEC22a 3

External Ids for SEC22A Gene

Previous HGNC Symbols for SEC22A Gene

  • SEC22L2

Previous GeneCards Identifiers for SEC22A Gene

  • GC03P119643
  • GC03P124404
  • GC03P122920
  • GC03P120295

Summaries for SEC22A Gene

Entrez Gene Summary for SEC22A Gene

  • The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. [provided by RefSeq, Nov 2008]

GeneCards Summary for SEC22A Gene

SEC22A (SEC22 Homolog A, Vesicle Trafficking Protein) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include transporter activity and SNAP receptor activity. An important paralog of this gene is SEC22C.

UniProtKB/Swiss-Prot for SEC22A Gene

  • May be involved in vesicle transport between the ER and the Golgi complex.

Gene Wiki entry for SEC22A Gene

Additional gene information for SEC22A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC22A Gene

Genomics for SEC22A Gene

GeneHancer (GH) Regulatory Elements for SEC22A Gene

Promoters and enhancers for SEC22A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J123200 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 680.7 +0.0 41 2.1 PKNOX1 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 POLR2B SEC22A ENSG00000273454 PDIA5
GH03J122645 Enhancer 1 Ensembl ENCODE 52.9 -555.2 -555209 1.5 SMAD1 ZFP64 YY1 ZNF121 ZNF213 IKZF2 ZNF680 ZBTB11 ZC3H11A REST GOLGB1 IQCB1 SEC22A LOC102723582 ENSG00000273454 PARP14 EIF4BP8 PIR41127
GH03J123272 Enhancer 0.8 Ensembl ENCODE 40.6 +71.4 71369 1.6 NFIA NFIB JUN SREBF1 NFIC LCORL JUND NFE2 ZNF300 MAFK SEC22A ENSG00000273454
GH03J122792 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.4 -407.5 -407501 3.9 CLOCK FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF213 HSPBAP1 DIRC2 ENSG00000273454 IQCB1 PARP14 SEC22A LOC102723582 LINC02035
GH03J123151 Enhancer 0.7 Ensembl 42.5 -49.9 -49926 0.4 HDGF ZSCAN26 ZNF473 YBX1 SALL2 ZNF366 ATF7 ETV6 ZNF571 ZIK1 SEC22A CCDC14 MYLK-AS1 ENSG00000273454 LOC102723582 SEMA5B MIR7110 PDIA5 GC03P123071
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEC22A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEC22A gene promoter:
  • LCR-F1
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • FOXJ2 (long isoform)
  • FOXJ2
  • TBP
  • Pax-4a

Genomic Locations for SEC22A Gene

Genomic Locations for SEC22A Gene
72,210 bases
Plus strand
72,210 bases
Plus strand

Genomic View for SEC22A Gene

Genes around SEC22A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC22A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC22A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC22A Gene

Proteins for SEC22A Gene

  • Protein details for SEC22A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicle-trafficking protein SEC22a
    Protein Accession:
    Secondary Accessions:
    • B2RE26
    • Q9Y682

    Protein attributes for SEC22A Gene

    307 amino acids
    Molecular mass:
    34948 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD43013.1; Type=Frameshift; Positions=265, 288; Evidence={ECO:0000305};

neXtProt entry for SEC22A Gene

Post-translational modifications for SEC22A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SEC22A Gene

Domains & Families for SEC22A Gene

Gene Families for SEC22A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SEC22A Gene

Suggested Antigen Peptide Sequences for SEC22A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the synaptobrevin family.
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with SEC22A: view

Function for SEC22A Gene

Molecular function for SEC22A Gene

UniProtKB/Swiss-Prot Function:
May be involved in vesicle transport between the ER and the Golgi complex.

Phenotypes From GWAS Catalog for SEC22A Gene

Gene Ontology (GO) - Molecular Function for SEC22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005215 transporter activity TAS 8621431
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with SEC22A: view
genes like me logo Genes that share phenotypes with SEC22A: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC22A Gene

Localization for SEC22A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC22A Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC22A gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
extracellular 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SEC22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031201 SNARE complex IBA --
genes like me logo Genes that share ontologies with SEC22A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SEC22A Gene

Pathways & Interactions for SEC22A Gene

genes like me logo Genes that share pathways with SEC22A: view

Gene Ontology (GO) - Biological Process for SEC22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 NOT exocytosis IBA --
GO:0006888 ER to Golgi vesicle-mediated transport IEA,IBA --
GO:0006906 vesicle fusion IBA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with SEC22A: view

No data available for SIGNOR curated interactions for SEC22A Gene

Drugs & Compounds for SEC22A Gene

No Compound Related Data Available

Transcripts for SEC22A Gene

mRNA/cDNA for SEC22A Gene

Unigene Clusters for SEC22A Gene

SEC22 vesicle trafficking protein homolog A (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC22A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - - - - - - - - - -
SP8: - -
SP9: -
SP10: -

Relevant External Links for SEC22A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC22A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC22A Gene

Protein differential expression in normal tissues from HIPED for SEC22A Gene

This gene is overexpressed in Islet of Langerhans (21.1) and Testis (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SEC22A Gene

NURSA nuclear receptor signaling pathways regulating expression of SEC22A Gene:


SOURCE GeneReport for Unigene cluster for SEC22A Gene:


Evidence on tissue expression from TISSUES for SEC22A Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with SEC22A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC22A Gene

Orthologs for SEC22A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC22A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEC22A 34 33
  • 99.89 (n)
(Bos Taurus)
Mammalia SEC22A 34 33
  • 95.55 (n)
(Canis familiaris)
Mammalia SEC22A 34 33
  • 95.11 (n)
(Mus musculus)
Mammalia Sec22a 16 34 33
  • 93.38 (n)
(Rattus norvegicus)
Mammalia Sec22a 33
  • 92.73 (n)
(Monodelphis domestica)
Mammalia SEC22A 34
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia SEC22A 34
  • 56 (a)
(Gallus gallus)
Aves SEC22A 34 33
  • 81.22 (n)
(Anolis carolinensis)
Reptilia SEC22A 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec22l2 33
  • 66.45 (n)
Str.10293 33
(Danio rerio)
Actinopterygii sec22a 34 33
  • 68.21 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta Sec22 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea sec-22 34
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC22 36 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
Species where no ortholog for SEC22A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC22A Gene

Gene Tree for SEC22A (if available)
Gene Tree for SEC22A (if available)
Evolutionary constrained regions (ECRs) for SEC22A: view image

Paralogs for SEC22A Gene

Paralogs for SEC22A Gene

(2) SIMAP similar genes for SEC22A Gene using alignment to 8 proteins:

  • C9J463_HUMAN
  • C9JR77_HUMAN
  • C9JZ27_HUMAN
genes like me logo Genes that share paralogs with SEC22A: view

Variants for SEC22A Gene

Sequence variations from dbSNP and Humsavar for SEC22A Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000079850 -- 123,219,489(+) A/G intron_variant
rs1000109860 -- 123,235,473(+) C/G intron_variant
rs1000131704 -- 123,248,321(+) A/G intron_variant
rs1000167391 -- 123,223,278(+) C/T intron_variant
rs1000212545 -- 123,237,272(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SEC22A Gene

Variant ID Type Subtype PubMed ID
dgv297n21 CNV loss 19592680
esv275521 CNV gain+loss 21479260
nsv1003681 CNV gain 25217958
nsv1013747 CNV loss 25217958
nsv1127990 CNV deletion 24896259
nsv3976 CNV insertion 18451855
nsv524614 CNV loss 19592680

Variation tolerance for SEC22A Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC22A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC22A Gene

Disorders for SEC22A Gene

Additional Disease Information for SEC22A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SEC22A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC22A Gene

Publications for SEC22A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58
  5. Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24. (PMID: 9501016) Tang BL … Hong W (Biochemical and biophysical research communications 1998) 2 3 58

Products for SEC22A Gene

Sources for SEC22A Gene

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