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Aliases for GGCX Gene

Aliases for GGCX Gene

  • Gamma-Glutamyl Carboxylase 2 3 4 5
  • Peptidyl-Glutamate 4-Carboxylase 2 3 4
  • Vitamin K-Dependent Gamma-Carboxylase 2 3
  • Vitamin K Gamma Glutamyl Carboxylase 4
  • EC 4.1.1.90 4
  • VKCFD1 3
  • GC 4

External Ids for GGCX Gene

Previous GeneCards Identifiers for GGCX Gene

  • GC02M085671
  • GC02M086070
  • GC02M085733
  • GC02M085750
  • GC02M085687
  • GC02M085629
  • GC02M085774
  • GC02M085673
  • GC02M085771

Summaries for GGCX Gene

Entrez Gene Summary for GGCX Gene

  • This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. The vitamin K-dependent protein substrates have a propeptide that binds the enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting as co-substrates. Vitamin K-dependent proteins affect a number of physiologic processes including blood coagulation, prevention of vascular calcification, and inflammation. Allelic variants of this gene have been associated with pseudoxanthoma elasticum-like disorder with associated multiple coagulation factor deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

GeneCards Summary for GGCX Gene

GGCX (Gamma-Glutamyl Carboxylase) is a Protein Coding gene. Diseases associated with GGCX include Pseudoxanthoma Elasticum-Like Disorder With Multiple Coagulation Factor Deficiency and Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 1. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Ubiquinol biosynthesis. Gene Ontology (GO) annotations related to this gene include gamma-glutamyl carboxylase activity.

UniProtKB/Swiss-Prot for GGCX Gene

  • Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.

Gene Wiki entry for GGCX Gene

Additional gene information for GGCX Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGCX Gene

Genomics for GGCX Gene

GeneHancer (GH) Regulatory Elements for GGCX Gene

Promoters and enhancers for GGCX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J085560 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.3 294 2.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B VAMP8 GGCX USP39 CAPG SH2D6 TMEM150A ELMOD3 RETSAT SNORD94 GC02P085546
GH02J085536 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.6 +21.8 21787 6.9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MAT2A PIR39955 PIR40998 PARTICL GC02M085541 USP39 SNORD94 C2orf68 LOC100996506 KDM3A
GH02J085582 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.3 -23.3 -23285 3.9 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 VAMP5 ELMOD3 SNORD94 VAMP8 GGCX SH2D6 CAPG MAT2A RETSAT USP39
GH02J085587 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 24.4 -28.3 -28280 5.2 PKNOX1 FOXA2 MLX ARNT ARID4B SLC30A9 ZNF766 FOS SP5 NFYC GGCX VAMP8 C2orf68 USP39 CHMP3 VAMP5 RNF181
GH02J085575 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 11.8 -16.8 -16797 4.7 HDGF ARID4B SIN3A DMAP1 ZNF48 YY1 POLR2B ZNF766 GLIS2 NFKBIZ VAMP8 VAMP5 USP39 TMEM150A GGCX MAT2A SH2D6 CAPG ELMOD3 RETSAT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GGCX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GGCX gene promoter:
  • E2F
  • Olf-1
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Pbx1a
  • Nkx2-5
  • ZIC2

Genomic Locations for GGCX Gene

Genomic Locations for GGCX Gene
chr2:85,544,723-85,561,547
(GRCh38/hg38)
Size:
16,825 bases
Orientation:
Minus strand
chr2:85,771,846-85,788,670
(GRCh37/hg19)
Size:
16,825 bases
Orientation:
Minus strand

Genomic View for GGCX Gene

Genes around GGCX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGCX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGCX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGCX Gene

Proteins for GGCX Gene

  • Protein details for GGCX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P38435-VKGC_HUMAN
    Recommended name:
    Vitamin K-dependent gamma-carboxylase
    Protein Accession:
    P38435
    Secondary Accessions:
    • B4DMC5
    • E9PEE1
    • Q14415
    • Q6GU45

    Protein attributes for GGCX Gene

    Size:
    758 amino acids
    Molecular mass:
    87561 Da
    Quaternary structure:
    • Monomer. May interact with CALU (By similarity).
    Miscellaneous:
    • The vitamin K-dependent protein substrates of carboxylase have usually a propeptide that binds to a high-affinity site on the carboxylase. CO(2), O(2) and reduced vitamin K are cosubstrates.

    Alternative splice isoforms for GGCX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GGCX Gene

Post-translational modifications for GGCX Gene

  • Glycosylation at isoforms=2550 and Asn459
  • Ubiquitination at isoforms=2334 and Lys91
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GGCX Gene

Domains & Families for GGCX Gene

Gene Families for GGCX Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Predicted membrane proteins

Protein Domains for GGCX Gene

Graphical View of Domain Structure for InterPro Entry

P38435

UniProtKB/Swiss-Prot:

VKGC_HUMAN :
  • Belongs to the vitamin K-dependent gamma-carboxylase family.
Family:
  • Belongs to the vitamin K-dependent gamma-carboxylase family.
genes like me logo Genes that share domains with GGCX: view

Function for GGCX Gene

Molecular function for GGCX Gene

UniProtKB/Swiss-Prot Function:
Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
UniProtKB/Swiss-Prot CatalyticActivity:
[Peptidyl]-4-carboxyglutamate + 2,3-epoxyphylloquinone + H(2)O = [peptidyl]-glutamate + CO(2) + O(2) + phylloquinol.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7. {ECO:0000269 PubMed:17073445};
GENATLAS Biochemistry:
gamma-glutamyl carboxylase,activating vitamin K-dependent proteins,widely expressed

Enzyme Numbers (IUBMB) for GGCX Gene

Phenotypes From GWAS Catalog for GGCX Gene

Gene Ontology (GO) - Molecular Function for GGCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008488 gamma-glutamyl carboxylase activity IEA,TAS --
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with GGCX: view
genes like me logo Genes that share phenotypes with GGCX: view

Human Phenotype Ontology for GGCX Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GGCX Gene

MGI Knock Outs for GGCX:

Animal Model Products

miRNA for GGCX Gene

miRTarBase miRNAs that target GGCX

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for GGCX Gene

Localization for GGCX Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGCX Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GGCX gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 2
peroxisome 2
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GGCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane TAS 1749935
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with GGCX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GGCX Gene

Pathways & Interactions for GGCX Gene

genes like me logo Genes that share pathways with GGCX: view

Gene Ontology (GO) - Biological Process for GGCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 1749935
GO:0007596 blood coagulation TAS 9845520
GO:0017187 peptidyl-glutamic acid carboxylation IEA,TAS --
genes like me logo Genes that share ontologies with GGCX: view

No data available for SIGNOR curated interactions for GGCX Gene

Drugs & Compounds for GGCX Gene

(16) Drugs for GGCX Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Anisindione Approved Pharma inhibitor, Target 0
Menadione Approved Nutra inhibitor, Target, cofactor 257
Glutamic Acid Approved Nutra Full agonist, Agonist, Target 251
Phytonadione Approved, Investigational Nutra cofactor, Target, inducer 257
Warfarin Approved Pharma 505

(15) Additional Compounds for GGCX Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2,3-Epoxymenaquinone
  • Vitamin K2 2,3-epoxide
  • Vitamin K2-2,3-epoxide
Menaquinol
  • Reduced menaquinone
  • Vitamin K2 hydroquinone
  • Reduced vitamin K2
Phylloquinol
  • Phytonadiol
  • Vitamin K hydroquinone
  • Vitamin K1 hydroquinone
  • Reduced vitamin K1
  • Dihydrovitamin K1
572-96-3
Reduced Vitamin K (phylloquinone)
  • 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione
  • 2-Methyl-3-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone
  • 2-Methyl-3-phytyl-1,4-naphthochinon
  • 2-Methyl-3-phytyl-1,4-naphthoquinone
  • 3-Phytylmenadione
81382-12-9
vitamin k1
  • Phytonadione
  • 2-Methyl-3-phytyl-1,4-naphthoquinone
  • Phytomenadione
  • Mephyton
  • 2',3'-trans-Vitamin K1
12001-79-5
genes like me logo Genes that share compounds with GGCX: view

Transcripts for GGCX Gene

Unigene Clusters for GGCX Gene

Gamma-glutamyl carboxylase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGCX Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^
SP1: - -
SP2: - - - - - - - - - - - - - -
SP3:
SP4: - -
SP5: - -
SP6: -
SP7: - -
SP8: -
SP9:
SP10:
SP11: - - - - - - - - - - - - - - - - - - - - - -
SP12: -

ExUns: 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - - - - -
SP12:

Relevant External Links for GGCX Gene

GeneLoc Exon Structure for
GGCX
ECgene alternative splicing isoforms for
GGCX

Expression for GGCX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GGCX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GGCX Gene

This gene is overexpressed in Liver (x6.7).

Protein differential expression in normal tissues from HIPED for GGCX Gene

This gene is overexpressed in Nasal epithelium (34.5), Liver (9.9), and Breast (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GGCX Gene



Protein tissue co-expression partners for GGCX Gene

NURSA nuclear receptor signaling pathways regulating expression of GGCX Gene:

GGCX

SOURCE GeneReport for Unigene cluster for GGCX Gene:

Hs.77719

Evidence on tissue expression from TISSUES for GGCX Gene

  • Nervous system(4.7)
  • Liver(4.5)
  • Blood(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for GGCX Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • nervous
  • skeleton
Regions:
Head and neck:
  • ear
  • eye
  • face
  • head
  • nose
  • skull
Thorax:
  • clavicle
  • heart
  • heart valve
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • coagulation system
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with GGCX: view

No data available for mRNA Expression by UniProt/SwissProt for GGCX Gene

Orthologs for GGCX Gene

This gene was present in the common ancestor of animals.

Orthologs for GGCX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GGCX 34 33
  • 99.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GGCX 34 33
  • 90.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GGCX 34 33
  • 88.35 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ggcx 16 34 33
  • 87.14 (n)
rat
(Rattus norvegicus)
Mammalia Ggcx 33
  • 86.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
OneToMany
-- 34
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GGCX 34
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GGCX 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ggcx 33
  • 67.32 (n)
Str.10139 33
zebrafish
(Danio rerio)
Actinopterygii LOC100537604 33
  • 64.29 (n)
ggcx 34
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta GC 34 35 33
  • 53.16 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006363 33
  • 51.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToOne
Species where no ortholog for GGCX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GGCX Gene

ENSEMBL:
Gene Tree for GGCX (if available)
TreeFam:
Gene Tree for GGCX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GGCX: view image

Paralogs for GGCX Gene

No data available for Paralogs for GGCX Gene

Variants for GGCX Gene

Sequence variations from dbSNP and Humsavar for GGCX Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs10179904 likely-benign, Vitamin K-Dependent Clotting Factors 85,552,984(-) G/A coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, synonymous_variant
rs1050464340 uncertain-significance, Vitamin K-Dependent Clotting Factors 85,549,664(-) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs10700825 benign, Vitamin K-Dependent Clotting Factors 85,546,532(-) TG/TGTG 3_prime_UTR_variant, genic_downstream_transcript_variant
rs113066451 uncertain-significance, Vitamin K-Dependent Clotting Factors 85,545,372(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs113958713 likely-benign, Vitamin K-Dependent Clotting Factors 85,547,969(-) C/A/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GGCX Gene

Variant ID Type Subtype PubMed ID
nsv2811 CNV insertion 18451855
nsv961801 CNV duplication 23825009

Variation tolerance for GGCX Gene

Residual Variation Intolerance Score: 3.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.33; 76.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GGCX Gene

Human Gene Mutation Database (HGMD)
GGCX
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GGCX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGCX Gene

Disorders for GGCX Gene

MalaCards: The human disease database

(7) MalaCards diseases for GGCX Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search GGCX in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

VKGC_HUMAN
  • Combined deficiency of vitamin K-dependent clotting factors 1 (VKCFD1) [MIM:277450]: VKCFD leads to a bleeding tendency that is usually reversed by oral administration of vitamin K. {ECO:0000269 PubMed:10934213, ECO:0000269 PubMed:11071668, ECO:0000269 PubMed:15287948, ECO:0000269 PubMed:9845520}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency (PXEL-MCFD) [MIM:610842]: Characterized by hyperlaxity of the skin involving the entire body. Important phenotypic differences with classical PXE include much more severe skin laxity with spreading toward the trunk and limbs with thick, leathery skin folds rather than confinement to flexural areas, and no decrease in visual acuity. Moreover, detailed electron microscopic analyzes revealed that alterations of elastic fibers as well as their mineralization are slightly different from those in classic PXE. {ECO:0000269 PubMed:17110937}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for GGCX Gene

combined deficiency of all vitamin K-dependent blood coagulation factors

Additional Disease Information for GGCX

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GGCX: view

Publications for GGCX Gene

  1. Cloning and expression of the cDNA for human gamma-glutamyl carboxylase. (PMID: 1749935) Wu SM … Stafford DW (Science (New York, N.Y.) 1991) 2 3 4 22 58
  2. Genetic determinants of acenocoumarol and phenprocoumon maintenance dose requirements. (PMID: 20020283) Cadamuro J … Oberkofler H (European journal of clinical pharmacology 2010) 3 22 44 58
  3. Genotype polymorphisms of GGCX, NQO1, and VKORC1 genes associated with risk susceptibility in patients with large-artery atherosclerotic stroke. (PMID: 20193673) Shyu HY … Cheng CW (Clinica chimica acta; international journal of clinical chemistry 2010) 3 22 44 58
  4. A multiplex assay for detecting genetic variations in CYP2C9, VKORC1, and GGCX involved in warfarin metabolism. (PMID: 19233910) Rai AJ … Fleisher M (Clinical chemistry 2009) 3 22 44 58
  5. Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status. (PMID: 19436136) Crosier MD … Ordovas JM (Journal of nutritional science and vitaminology 2009) 3 22 44 58

Products for GGCX Gene

Sources for GGCX Gene