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Aliases for GFRA3 Gene

Aliases for GFRA3 Gene

  • GDNF Family Receptor Alpha 3 2 3 5
  • GDNF Receptor Alpha-3 3 4
  • GDNFR-Alpha-3 3 4
  • GFR-Alpha-3 3 4
  • Glial Cell Line-Derived Neurotrophic Factor Receptor Alpha-3 3
  • GDNF Family Receptor Alpha-3 3
  • GPI-Linked Receptor 3
  • GDNFR3 3

External Ids for GFRA3 Gene

Previous GeneCards Identifiers for GFRA3 Gene

  • GC05M137463
  • GC05M137618
  • GC05M137665
  • GC05M137666
  • GC05M137615
  • GC05M137588
  • GC05M132780

Summaries for GFRA3 Gene

Entrez Gene Summary for GFRA3 Gene

  • The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008]

GeneCards Summary for GFRA3 Gene

GFRA3 (GDNF Family Receptor Alpha 3) is a Protein Coding gene. Among its related pathways are RET signaling and Developmental Biology. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and axon guidance receptor activity. An important paralog of this gene is GFRA1.

UniProtKB/Swiss-Prot for GFRA3 Gene

  • Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.

Gene Wiki entry for GFRA3 Gene

Additional gene information for GFRA3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GFRA3 Gene

Genomics for GFRA3 Gene

GeneHancer (GH) Regulatory Elements for GFRA3 Gene

Promoters and enhancers for GFRA3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J138274 Promoter 1.3 EPDnew Ensembl 650.7 +0.1 71 0.4 EGR1 SIN3A ZBTB33 EZH2 GFRA3 RPS27AP18 GC05M138244
GH05J138350 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.2 -78.7 -78664 4.7 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 SLC30A9 KDM3B CDC23 BRD8 HNRNPA0 FAM53C RPL7P19 FAM13B KIF20A GFRA3 REEP2
GH05J138222 Enhancer 1.1 Ensembl ENCODE 16.6 +51.7 51712 0.5 FOXA2 ARNT ARID4B ZNF48 YY1 ZNF213 ELK1 ARID2 ZNF143 RXRA BRD8 GFRA3 HNRNPA0 CDC23 KDM3B KIF20A GC05M138210
GH05J138330 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 8.4 -56.9 -56889 2.1 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 FAM53C LOC100128966 CDC25C HNRNPA0 KDM3B GFRA3 LOC105379194 GC05P138279 GC05M138244
GH05J138368 Enhancer 1 Ensembl ENCODE dbSUPER 9.2 -95.2 -95230 3.8 FOXA2 CBFA2T3 ATF2 ZNF121 ZNF316 EGR1 EMSY WT1 MAFK FAM53C CDC25C ENSG00000249971 BRD8 KIF20A HSPA9 GFRA3 KDM3B REEP2 GC05P138377
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GFRA3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GFRA3 gene promoter:
  • POU2F1a
  • POU2F1
  • Max1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • GATA-2
  • AML1a
  • PPAR-alpha
  • STAT3

Genomic Locations for GFRA3 Gene

Genomic Locations for GFRA3 Gene
22,293 bases
Minus strand
22,293 bases
Minus strand

Genomic View for GFRA3 Gene

Genes around GFRA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GFRA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GFRA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GFRA3 Gene

Proteins for GFRA3 Gene

  • Protein details for GFRA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GDNF family receptor alpha-3
    Protein Accession:
    Secondary Accessions:
    • B2RA36
    • B4DMY9
    • Q6UW20
    • Q8IUZ2

    Protein attributes for GFRA3 Gene

    400 amino acids
    Molecular mass:
    44511 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GFRA3 Gene

    Alternative splice isoforms for GFRA3 Gene


neXtProt entry for GFRA3 Gene

Post-translational modifications for GFRA3 Gene

Other Protein References for GFRA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GFRA3 Gene

Domains & Families for GFRA3 Gene

Gene Families for GFRA3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for GFRA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GDNFR family.
  • Belongs to the GDNFR family.
genes like me logo Genes that share domains with GFRA3: view

Function for GFRA3 Gene

Molecular function for GFRA3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
GENATLAS Biochemistry:
glial cell line-derived neurotrophic factor (GDNF) receptor alpha 3,43/62kDa,predominantly expressed in the cerebellum and spinal cord,also expressed in stomach,colon and several other tissues,not involved in RET signaling

Phenotypes From GWAS Catalog for GFRA3 Gene

Gene Ontology (GO) - Molecular Function for GFRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005102 signaling receptor binding TAS 9407096
GO:0005515 protein binding IPI 16765900
GO:0008046 axon guidance receptor activity IEA --
genes like me logo Genes that share ontologies with GFRA3: view
genes like me logo Genes that share phenotypes with GFRA3: view

Animal Models for GFRA3 Gene

MGI Knock Outs for GFRA3:

Animal Model Products

miRNA for GFRA3 Gene

miRTarBase miRNAs that target GFRA3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GFRA3 Gene

Localization for GFRA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GFRA3 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GFRA3 gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GFRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0019898 extrinsic component of membrane TAS 9490034
genes like me logo Genes that share ontologies with GFRA3: view

Pathways & Interactions for GFRA3 Gene

SuperPathways for GFRA3 Gene

SuperPathway Contained pathways
1 RET signaling
2 GDNF-Family Ligands and Receptor Interactions
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 Innate Immune System
genes like me logo Genes that share pathways with GFRA3: view

Pathways by source for GFRA3 Gene

1 GeneGo (Thomson Reuters) pathway for GFRA3 Gene
1 Qiagen pathway for GFRA3 Gene

SIGNOR curated interactions for GFRA3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GFRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001764 neuron migration IEA --
GO:0007165 signal transduction TAS 9490034
GO:0007399 nervous system development TAS 9490034
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with GFRA3: view

Drugs & Compounds for GFRA3 Gene

(1) Drugs for GFRA3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with GFRA3: view

Transcripts for GFRA3 Gene

mRNA/cDNA for GFRA3 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(45) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GFRA3 Gene

GDNF family receptor alpha 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GFRA3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP2: - -

Relevant External Links for GFRA3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GFRA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GFRA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GFRA3 Gene

This gene is overexpressed in Nerve - Tibial (x12.2) and Esophagus - Muscularis (x4.0).

Protein differential expression in normal tissues from HIPED for GFRA3 Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GFRA3 Gene

Protein tissue co-expression partners for GFRA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of GFRA3 Gene:


SOURCE GeneReport for Unigene cluster for GFRA3 Gene:


mRNA Expression by UniProt/SwissProt for GFRA3 Gene:

Tissue specificity: Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.

Evidence on tissue expression from TISSUES for GFRA3 Gene

  • Nervous system(4.3)
  • Lung(4.2)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with GFRA3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GFRA3 Gene

Orthologs for GFRA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GFRA3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GFRA3 34 33
  • 99.17 (n)
(Canis familiaris)
Mammalia GFRA3 34 33
  • 87.61 (n)
(Bos Taurus)
Mammalia GFRA3 34 33
  • 87.3 (n)
(Rattus norvegicus)
Mammalia Gfra3 33
  • 84.08 (n)
(Mus musculus)
Mammalia Gfra3 16 34 33
  • 83.99 (n)
(Monodelphis domestica)
Mammalia GFRA3 34
  • 49 (a)
(Gallus gallus)
Aves GFRA3 34
  • 39 (a)
(Anolis carolinensis)
Reptilia GFRA3 34
  • 30 (a)
(Danio rerio)
Actinopterygii gfra3 34
  • 28 (a)
Species where no ortholog for GFRA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GFRA3 Gene

Gene Tree for GFRA3 (if available)
Gene Tree for GFRA3 (if available)
Evolutionary constrained regions (ECRs) for GFRA3: view image

Paralogs for GFRA3 Gene

Paralogs for GFRA3 Gene

(2) SIMAP similar genes for GFRA3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GFRA3: view

Variants for GFRA3 Gene

Sequence variations from dbSNP and Humsavar for GFRA3 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs193921100 uncertain-significance, Malignant tumor of prostate 138,253,036(-) G/T coding_sequence_variant, missense_variant
rs1000225033 -- 138,271,165(-) T/C intron_variant
rs1000243771 -- 138,263,428(-) T/C intron_variant
rs1000403178 -- 138,267,164(-) C/G intron_variant
rs1000414290 -- 138,267,540(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GFRA3 Gene

Variant ID Type Subtype PubMed ID
dgv3179n106 CNV deletion 24896259
esv2678510 CNV deletion 23128226
esv2730821 CNV deletion 23290073
esv3389910 CNV duplication 20981092
esv3566700 CNV deletion 23714750
nsv1152536 CNV deletion 26484159

Variation tolerance for GFRA3 Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GFRA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GFRA3 Gene

Disorders for GFRA3 Gene

Additional Disease Information for GFRA3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GFRA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GFRA3 Gene

Publications for GFRA3 Gene

  1. GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. (PMID: 9576965) Baloh RH … Milbrandt J (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 22 58
  2. GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. (PMID: 9407096) Jing S … Fox GM (The Journal of biological chemistry 1997) 2 3 22 58
  3. [Artemin and GFRalpha3 expressions and their relevance to perineural invasiveness and metastasis of pancreatic carcinoma]. (PMID: 19304517) Zhu DL … Gao JM (Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2009) 3 22 58
  4. Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors. (PMID: 16765900) Wang X … Garcia KC (Structure (London, England : 1993) 2006) 3 4 58
  5. Distribution of GDNF family receptor alpha3 and RET in rat and human non-neural tissues. (PMID: 16773224) Yang C … Sah DW (Journal of molecular histology 2006) 3 22 58

Products for GFRA3 Gene

Sources for GFRA3 Gene

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