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Aliases for CKAP2 Gene

Aliases for CKAP2 Gene

  • Cytoskeleton Associated Protein 2 2 3 5
  • Tumor- And Microtubule-Associated Protein 3 4
  • CTCL Tumor Antigen Se20-10 3 4
  • TMAP 3 4
  • LB1 3 4
  • Tumor-Associated Microtubule-Associated Protein 3
  • Cytoskeleton-Associated Protein 2 3
  • Se20-10 3

External Ids for CKAP2 Gene

Previous GeneCards Identifiers for CKAP2 Gene

  • GC13P050997
  • GC13P047024
  • GC13P051966
  • GC13P050827
  • GC13P051927
  • GC13P053029
  • GC13P033768

Summaries for CKAP2 Gene

Entrez Gene Summary for CKAP2 Gene

  • This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]

GeneCards Summary for CKAP2 Gene

CKAP2 (Cytoskeleton Associated Protein 2) is a Protein Coding gene. Diseases associated with CKAP2 include Inclusion Conjunctivitis. An important paralog of this gene is CKAP2L.

UniProtKB/Swiss-Prot for CKAP2 Gene

  • Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).

Gene Wiki entry for CKAP2 Gene

Additional gene information for CKAP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKAP2 Gene

Genomics for CKAP2 Gene

GeneHancer (GH) Regulatory Elements for CKAP2 Gene

Promoters and enhancers for CKAP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J052453 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 697.8 +0.1 62 4.3 PKNOX1 SMAD1 FOXA2 ARID4B SIN3A IRF4 POLR2B ZNF766 ZNF207 ZNF143 CKAP2 ENSG00000278238 TPTE2P2 THSD1 ALG11 NEK5 GC13M052475
GH13J052448 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 36.7 -5.6 -5566 3 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF207 ZNF143 SP5 VPS36 CKAP2 TPTE2P2 HNRNPA1L2 THSD1 INTS6-AS1
GH13J052193 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 34.3 -260.7 -260700 2.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MRPS31P5 ALG11 RPS4XP16 SUGT1 CKAP2 INTS6 SERPINE3 INTS6-AS1 TPTE2P2 UTP14C
GH13J052650 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.3 +197.3 197265 3.7 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 POLR2B ENSG00000273723 SUGT1 ALG11 CKAP2 TPTE2P2 UTP14C
GH13J052598 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 24.9 +144.6 144584 2.5 PKNOX1 ARNT ZSCAN4 SIN3A GLI4 ZNF2 YY1 ZNF335 ZNF366 EGR2 ENSG00000273784 MRPS31P4 LINC00345 VPS36 CKAP2 TPTE2P2 GC13P052591 PIR38290 GC13P052592
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CKAP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CKAP2 gene promoter:
  • PPAR-alpha
  • CBF-B
  • CBF(2)
  • CBF-A
  • CBF-C
  • CP1A
  • CP1C
  • NF-Y
  • NF-YA
  • NF-YB

Genomic Locations for CKAP2 Gene

Genomic Locations for CKAP2 Gene
21,272 bases
Plus strand
21,269 bases
Plus strand

Genomic View for CKAP2 Gene

Genes around CKAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKAP2 Gene

Proteins for CKAP2 Gene

  • Protein details for CKAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytoskeleton-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • A2BDE0
    • A5YM58
    • B4DR35
    • E9PD90
    • Q3KRA5
    • Q5VXB4
    • Q8IWV5
    • Q8IWV6
    • Q96FH9
    • Q9H012
    • Q9H0D0
    • Q9H988
    • Q9HC49
    • Q9NVG4

    Protein attributes for CKAP2 Gene

    683 amino acids
    Molecular mass:
    76987 Da
    Quaternary structure:
    • Associates with alpha- and beta-tubulins.
    • Sequence=AAG33675.1; Type=Frameshift; Positions=604; Evidence={ECO:0000305}; Sequence=AAG33675.1; Type=Frameshift; Positions=607; Evidence={ECO:0000305}; Sequence=AAH10901.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI05807.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91788.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CKAP2 Gene


neXtProt entry for CKAP2 Gene

Post-translational modifications for CKAP2 Gene

  • Ubiquitination at posLast=620620, Lys617, and Lys70
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CKAP2
  • Boster Bio Antibodies for CKAP2

No data available for DME Specific Peptides for CKAP2 Gene

Domains & Families for CKAP2 Gene

Gene Families for CKAP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CKAP2 Gene


Suggested Antigen Peptide Sequences for CKAP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CKAP2 family.
  • Belongs to the CKAP2 family.
genes like me logo Genes that share domains with CKAP2: view

Function for CKAP2 Gene

Molecular function for CKAP2 Gene

UniProtKB/Swiss-Prot Function:
Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated in primary human gastric cancers.

Phenotypes From GWAS Catalog for CKAP2 Gene

genes like me logo Genes that share phenotypes with CKAP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CKAP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CKAP2 Gene

Localization for CKAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKAP2 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CKAP2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (4)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CKAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005819 spindle IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CKAP2: view

Pathways & Interactions for CKAP2 Gene

SuperPathways for CKAP2 Gene

No Data Available

SIGNOR curated interactions for CKAP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CKAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IGI 16061649
GO:0006915 apoptotic process IEA --
GO:0007026 negative regulation of microtubule depolymerization IEA --
GO:0007049 cell cycle IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IGI 16061649
genes like me logo Genes that share ontologies with CKAP2: view

No data available for Pathways by source for CKAP2 Gene

Drugs & Compounds for CKAP2 Gene

(3) Drugs for CKAP2 Gene - From:

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vincristine Approved, Investigational Pharma Microtubule disrupter,antitumor agent 965
10-DAB (10-Deacetylbaccatin) Pharma Precursor of antitumor compound Palitaxel and Docetaxel 0
ABT-751 (E7010) Pharma Inhibitor of microtubule polymerization,antimitotic 0
genes like me logo Genes that share compounds with CKAP2: view

Transcripts for CKAP2 Gene

Unigene Clusters for CKAP2 Gene

Cytoskeleton associated protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CKAP2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CKAP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: -
SP4: -

Relevant External Links for CKAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CKAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CKAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CKAP2 Gene

This gene is overexpressed in Testis (32.4), Peripheral blood mononuclear cells (14.7), and Ovary (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CKAP2 Gene

Protein tissue co-expression partners for CKAP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CKAP2 Gene:


SOURCE GeneReport for Unigene cluster for CKAP2 Gene:


mRNA Expression by UniProt/SwissProt for CKAP2 Gene:

Tissue specificity: Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.

Evidence on tissue expression from TISSUES for CKAP2 Gene

  • Lung(4.6)
  • Intestine(4.2)
  • Nervous system(3.8)
  • Pancreas(2.6)
  • Stomach(2.4)
  • Bone(2.3)
genes like me logo Genes that share expression patterns with CKAP2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CKAP2 Gene

Orthologs for CKAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CKAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CKAP2 34 33
  • 98.98 (n)
(Canis familiaris)
Mammalia CKAP2 34 33
  • 81.18 (n)
(Bos Taurus)
Mammalia CKAP2 34 33
  • 79.3 (n)
(Mus musculus)
Mammalia Ckap2 16 34 33
  • 75.18 (n)
(Rattus norvegicus)
Mammalia Ckap2 33
  • 74.41 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
-- 34
  • 48 (a)
-- 34
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 47 (a)
-- 34
  • 39 (a)
(Gallus gallus)
Aves CKAP2 34 33
  • 54.46 (n)
(Anolis carolinensis)
Reptilia CKAP2 34
  • 31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ckap2 33
  • 51.26 (n)
Str.6556 33
(Danio rerio)
Actinopterygii si:ch211-266i6.3 33
  • 46.51 (n)
CKAP2 34
  • 24 (a)
Species where no ortholog for CKAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CKAP2 Gene

Gene Tree for CKAP2 (if available)
Gene Tree for CKAP2 (if available)
Evolutionary constrained regions (ECRs) for CKAP2: view image

Paralogs for CKAP2 Gene

Paralogs for CKAP2 Gene Pseudogenes for CKAP2 Gene

genes like me logo Genes that share paralogs with CKAP2: view

Variants for CKAP2 Gene

Sequence variations from dbSNP and Humsavar for CKAP2 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000081578 -- 52,470,372(+) T/TT genic_downstream_transcript_variant, intron_variant
rs1000100365 -- 52,463,404(+) C/T intron_variant
rs1000320568 -- 52,472,450(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000594134 -- 52,455,775(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000835057 -- 52,463,831(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CKAP2 Gene

Variant ID Type Subtype PubMed ID
esv1661627 CNV deletion 17803354
esv2423190 CNV insertion 19546169
esv3326145 CNV duplication 20981092
esv3632093 CNV loss 21293372
esv3632094 CNV loss 21293372
esv3892344 CNV loss 25118596
nsv1110855 OTHER inversion 24896259
nsv428288 CNV loss 18775914
nsv7242 OTHER inversion 18451855

Variation tolerance for CKAP2 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CKAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKAP2 Gene

Disorders for CKAP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CKAP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
inclusion conjunctivitis
  • adult inclusion conjunctivitis
- elite association - COSMIC cancer census association via MalaCards
Search CKAP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CKAP2

genes like me logo Genes that share disorders with CKAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CKAP2 Gene

Publications for CKAP2 Gene

  1. Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B cell lymphomas. (PMID: 9771967) Maouche-Chrétien L … Leroy-Viard K (Oncogene 1998) 2 3 4 58
  2. Characterization of mitosis-specific phosphorylation of tumor-associated microtubule-associated protein. (PMID: 19641375) Hong KU … Park J (Experimental & molecular medicine 2009) 3 22 58
  3. Cdk1-cyclin B1-mediated phosphorylation of tumor-associated microtubule-associated protein/cytoskeleton-associated protein 2 in mitosis. (PMID: 19369249) Hong KU … Park J (The Journal of biological chemistry 2009) 3 22 58
  4. Transient phosphorylation of tumor associated microtubule associated protein (TMAP)/cytoskeleton associated protein 2 (CKAP2) at Thr-596 during early phases of mitosis. (PMID: 18779650) Hong KU … Hong KM (Experimental & molecular medicine 2008) 3 22 58
  5. CKAP2 is a spindle-associated protein degraded by APC/C-Cdh1 during mitotic exit. (PMID: 17376772) Seki A … Fang G (The Journal of biological chemistry 2007) 3 4 58

Products for CKAP2 Gene

Sources for CKAP2 Gene

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