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Aliases for HSPB8 Gene

Aliases for HSPB8 Gene

  • Heat Shock Protein Family B (Small) Member 8 2 3 5
  • Small Stress Protein-Like Protein HSP22 3 4
  • Heat Shock 22kDa Protein 8 2 3
  • Heat Shock 27kDa Protein 8 2 3
  • E2-Induced Gene 1 Protein 3 4
  • Alpha-Crystallin C Chain 3 4
  • Protein Kinase H11 3 4
  • E2IG1 3 4
  • HSP22 3 4
  • Heat Shock Protein Beta-8 3
  • CMT2L 3
  • DHMN2 3
  • HMN2A 3
  • CRYAC 4
  • HspB8 4
  • HMN2 3
  • H11 3

External Ids for HSPB8 Gene

Previous GeneCards Identifiers for HSPB8 Gene

  • GC12P118028
  • GC12P118079
  • GC12P119616
  • GC12P116624

Summaries for HSPB8 Gene

Entrez Gene Summary for HSPB8 Gene

  • The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPB8 Gene

HSPB8 (Heat Shock Protein Family B (Small) Member 8) is a Protein Coding gene. Diseases associated with HSPB8 include Charcot-Marie-Tooth Disease, Axonal, Type 2L and Neuronopathy, Distal Hereditary Motor, Type Iia. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is HSPB1.

UniProtKB/Swiss-Prot for HSPB8 Gene

  • Displays temperature-dependent chaperone activity.

Gene Wiki entry for HSPB8 Gene

Additional gene information for HSPB8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB8 Gene

Genomics for HSPB8 Gene

GeneHancer (GH) Regulatory Elements for HSPB8 Gene

Promoters and enhancers for HSPB8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J119174 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 656.8 +0.7 743 9.4 PKNOX1 ATF1 NEUROD1 SIN3A ZNF2 BRCA1 GLIS2 FOS ATF7 DEK HSPB8 LOC100287653 ENSG00000256609 LOC105370024
GH12J119235 Enhancer 0.5 ENCODE 11.1 +56.9 56869 0.2 CTCF TEAD1 TEAD4 TEAD2 TEAD3 LOC105370025 HSPB8 LOC105370024 GC12P119226
GH12J119201 Enhancer 1 Ensembl ENCODE dbSUPER 5.2 +25.0 24968 3.5 USF1 MAFG REST SP1 POLR2A CTBP2 CREB1 RCOR1 MAFK HSPB8 LOC105370026 LOC100287653
GH12J119236 Enhancer 0.4 ENCODE 11.1 +57.9 57911 0.9 ZNF189 ZFP36 HSPB8 LOC105370024 GC12P119226 LOC105370025
GH12J119145 Enhancer 0.3 ENCODE 11.9 -33.1 -33095 0.5 CBX8 LOC105370024 HSPB8 LOC105370022 SRRM4 GC12P119156 GC12M119082
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSPB8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSPB8 gene promoter:
  • HNF-4alpha1
  • ZIC2
  • CP1A
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1C
  • NF-Y
  • NF-YA

Genomic Locations for HSPB8 Gene

Genomic Locations for HSPB8 Gene
42,490 bases
Plus strand
42,490 bases
Plus strand

Genomic View for HSPB8 Gene

Genes around HSPB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB8 Gene

Proteins for HSPB8 Gene

  • Protein details for HSPB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock protein beta-8
    Protein Accession:
    Secondary Accessions:
    • B2R6A6
    • Q6FIH3
    • Q9UKS3

    Protein attributes for HSPB8 Gene

    196 amino acids
    Molecular mass:
    21604 Da
    Quaternary structure:
    • Monomer. Interacts with HSPB1. Interacts with DNAJB6. Interacts with BAG3 (PubMed:28144995).

neXtProt entry for HSPB8 Gene

Post-translational modifications for HSPB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPB8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPB8 Gene

Domains & Families for HSPB8 Gene

Gene Families for HSPB8 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for HSPB8 Gene

Suggested Antigen Peptide Sequences for HSPB8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small heat shock protein (HSP20) family.
  • Belongs to the small heat shock protein (HSP20) family.
genes like me logo Genes that share domains with HSPB8: view

Function for HSPB8 Gene

Molecular function for HSPB8 Gene

UniProtKB/Swiss-Prot Function:
Displays temperature-dependent chaperone activity.
UniProtKB/Swiss-Prot Induction:
By 17-beta-estradiol.

Phenotypes From GWAS Catalog for HSPB8 Gene

Gene Ontology (GO) - Molecular Function for HSPB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 NOT protein kinase activity IDA 14985082
GO:0005515 protein binding IPI 14594798
GO:0042802 identical protein binding IPI 14594798
genes like me logo Genes that share ontologies with HSPB8: view
genes like me logo Genes that share phenotypes with HSPB8: view

Human Phenotype Ontology for HSPB8 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HSPB8 Gene

MGI Knock Outs for HSPB8:

Animal Model Products

  • Taconic Biosciences Mouse Models for HSPB8

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPB8

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HSPB8 Gene

Localization for HSPB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB8 Gene

Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPB8 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 3
mitochondrion 2
extracellular 1
cytoskeleton 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HSPB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IDA,IEA 19464326
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 19464326
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with HSPB8: view

Pathways & Interactions for HSPB8 Gene

SuperPathways for HSPB8 Gene

No Data Available

SIGNOR curated interactions for HSPB8 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HSPB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:1900034 regulation of cellular response to heat TAS --
genes like me logo Genes that share ontologies with HSPB8: view

No data available for Pathways by source for HSPB8 Gene

Drugs & Compounds for HSPB8 Gene

(1) Additional Compounds for HSPB8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSPB8: view

Transcripts for HSPB8 Gene

mRNA/cDNA for HSPB8 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPB8 Gene

Heat shock 22kDa protein 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPB8

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB8 Gene

No ASD Table

Relevant External Links for HSPB8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPB8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPB8 Gene

mRNA differential expression in normal tissues according to GTEx for HSPB8 Gene

This gene is overexpressed in Muscle - Skeletal (x7.3) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for HSPB8 Gene

This gene is overexpressed in Cervix (23.8), Placenta (7.1), and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSPB8 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSPB8 Gene:


SOURCE GeneReport for Unigene cluster for HSPB8 Gene:


mRNA Expression by UniProt/SwissProt for HSPB8 Gene:

Tissue specificity: Predominantly expressed in skeletal muscle and heart.

Evidence on tissue expression from TISSUES for HSPB8 Gene

  • Nervous system(4.9)
  • Muscle(3.2)
  • Heart(3)
  • Eye(2.7)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPB8 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • cerebellum
  • head
  • lung
  • rib
  • rib cage
  • pelvis
  • arm
  • digit
  • foot
  • forearm
  • hand
  • lower limb
  • shin
  • thigh
  • toe
  • upper limb
  • peripheral nerve
  • peripheral nervous system
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with HSPB8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for HSPB8 Gene

Orthologs for HSPB8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSPB8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSPB8 34 33
  • 99.66 (n)
(Bos Taurus)
Mammalia HSPB8 34 33
  • 90.48 (n)
(Canis familiaris)
Mammalia HSPB8 34 33
  • 90.31 (n)
(Rattus norvegicus)
Mammalia Hspb8 33
  • 88.61 (n)
(Mus musculus)
Mammalia Hspb8 16 34 33
  • 87.24 (n)
(Monodelphis domestica)
Mammalia HSPB8 34
  • 66 (a)
(Gallus gallus)
Aves HSPB8 34 33
  • 71.26 (n)
(Anolis carolinensis)
Reptilia HSPB8 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hspb8 33
  • 64.29 (n)
Str.13095 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64408 33
(Danio rerio)
Actinopterygii hspb8 34 33
  • 62.34 (n)
wufc09c11 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.195 34
  • 33 (a)
Species where no ortholog for HSPB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPB8 Gene

Gene Tree for HSPB8 (if available)
Gene Tree for HSPB8 (if available)
Evolutionary constrained regions (ECRs) for HSPB8: view image

Paralogs for HSPB8 Gene

Paralogs for HSPB8 Gene

(3) SIMAP similar genes for HSPB8 Gene using alignment to 2 proteins:

  • H0YG30_HUMAN
genes like me logo Genes that share paralogs with HSPB8: view

Variants for HSPB8 Gene

Sequence variations from dbSNP and Humsavar for HSPB8 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs104894345 pathogenic, Distal hereditary motor neuronopathy type 2A, Charcot-Marie-Tooth disease, Charcot-Marie-Tooth disease, type 2L, Neuronopathy, distal hereditary motor, 2A (HMN2A) [MIM:158590] 119,187,080(+) G/C/T coding_sequence_variant, missense_variant
rs104894351 pathogenic, Distal hereditary motor neuronopathy type 2A, Charcot-Marie-Tooth disease, Neuronopathy, distal hereditary motor, 2A (HMN2A) [MIM:158590] 119,187,078(+) A/G coding_sequence_variant, missense_variant
rs11038 likely-benign, Charcot-Marie-Tooth, Type 2, Distal hereditary motor neuronopathy 119,194,502(+) A/G 3_prime_UTR_variant
rs112052602 likely-benign, benign, Distal hereditary motor neuronopathy, Charcot-Marie-Tooth, Type 2, not specified, Charcot-Marie-Tooth disease, type 2L 119,193,819(+) C/T coding_sequence_variant, synonymous_variant
rs1133026 likely-benign, Distal hereditary motor neuronopathy, Charcot-Marie-Tooth, Type 2 119,194,542(+) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for HSPB8 Gene

Variant ID Type Subtype PubMed ID
esv3580499 CNV loss 25503493
nsv902 CNV deletion 18451855
nsv983367 CNV duplication 23825009

Variation tolerance for HSPB8 Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPB8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPB8 Gene

Disorders for HSPB8 Gene

MalaCards: The human disease database

(15) MalaCards diseases for HSPB8 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards


  • Neuronopathy, distal hereditary motor, 2A (HMN2A) [MIM:158590]: A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. {ECO:0000269 PubMed:15122253, ECO:0000269 PubMed:28144995}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Charcot-Marie-Tooth disease 2L (CMT2L) [MIM:608673]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. {ECO:0000269 PubMed:15565283}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for HSPB8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HSPB8: view

No data available for Genatlas for HSPB8 Gene

Publications for HSPB8 Gene

  1. A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells. (PMID: 10833516) Smith CC … Aurelian L (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy. (PMID: 15122253) Irobi J … Timmerman V (Nature genetics 2004) 3 4 22 58
  3. Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9. (PMID: 11470154) Kappé G … De Jong WW (Biochimica et biophysica acta 2001) 3 4 22 58
  4. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. (PMID: 11085516) Charpentier AH … Aldaz CM (Cancer research 2000) 2 3 4 58
  5. Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations. (PMID: 28144995) Echaniz-Laguna A … Stojkovic T (Human mutation 2017) 3 4 58

Products for HSPB8 Gene

Sources for HSPB8 Gene

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