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Aliases for FBXO5 Gene

Aliases for FBXO5 Gene

  • F-Box Protein 5 2 3 5
  • Early Mitotic Inhibitor 1 3 4
  • F-Box Only Protein 5 2 3
  • EMI1 3 4
  • FBX5 3 4
  • F-Box Protein Fbx5 3
  • Fbxo31 3

External Ids for FBXO5 Gene

Previous GeneCards Identifiers for FBXO5 Gene

  • GC06M152852
  • GC06M153186
  • GC06M153322
  • GC06M153383
  • GC06M153333
  • GC06M153291
  • GC06M150854

Summaries for FBXO5 Gene

Entrez Gene Summary for FBXO5 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]

GeneCards Summary for FBXO5 Gene

FBXO5 (F-Box Protein 5) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is FBXO43.

UniProtKB/Swiss-Prot for FBXO5 Gene

  • Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.

Gene Wiki entry for FBXO5 Gene

Additional gene information for FBXO5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO5 Gene

Genomics for FBXO5 Gene

GeneHancer (GH) Regulatory Elements for FBXO5 Gene

Promoters and enhancers for FBXO5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J152980 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 718.1 +0.5 513 5.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 FBXO5 PIR33309 GC06P152985 ENSG00000227627 MTRF1L LOC105378065 LOC105378066 MTCO3P31 MTCO2P31 MTATP6P31
GH06J153786 Enhancer 0.7 ENCODE 54.9 -803.2 -803236 0.1 JUN ZFP64 ZNF140 ZNF266 ZNF697 ZNF213 FOS ZNF433 ZNF202 ZBTB11 FBXO5 SCAF8 RGS17 RPL27AP6 RNU6-896P GC06M153939
GH06J153787 Enhancer 0.6 ENCODE 54.9 -804.0 -804002 0.9 ZNF202 SP5 ZBTB11 ZFP64 ZNF140 ZNF266 ZC3H11A REST ZNF644 ZNF560 FBXO5 SCAF8 RPL27AP6 RNU6-896P GC06M153939
GH06J152093 Enhancer 1.1 Ensembl ENCODE 19.4 +887.5 887530 4.5 PKNOX1 ARNT FEZF1 ZNF213 ZNF143 ATF7 FOS SP3 ZNF662 TSHZ1 FBXO5 HSPA8P15 ZBTB2 ENSG00000284615 PIR34901 ESR1
GH06J152572 Enhancer 0.9 ENCODE 11.8 +410.6 410624 0.2 ZSCAN4 INSM2 KLF17 MZF1 FEZF1 KLF14 ZNF213 ZNF366 ZSCAN5C SCRT2 FBXO5 NANOGP11 SYNE1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXO5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXO5 gene promoter:
  • p53
  • HNF-3beta
  • E47
  • Tal-1
  • HNF-4alpha1
  • COUP

Genomic Locations for FBXO5 Gene

Genomic Locations for FBXO5 Gene
13,087 bases
Minus strand
13,083 bases
Minus strand

Genomic View for FBXO5 Gene

Genes around FBXO5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO5 Gene

Proteins for FBXO5 Gene

  • Protein details for FBXO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 5
    Protein Accession:
    Secondary Accessions:
    • B3KNX5
    • Q5TF47
    • Q8WV29
    • Q9UGC8

    Protein attributes for FBXO5 Gene

    447 amino acids
    Molecular mass:
    50146 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with BTRC, FZR1/CDH1 and the N-terminal substrate-binding domain of CDC20. Also interacts with EVI5 which blocks its phosphorylation by PLK1 and prevents its subsequent binding to BTRC and degradation.

    Three dimensional structures from OCA and Proteopedia for FBXO5 Gene

    Alternative splice isoforms for FBXO5 Gene


neXtProt entry for FBXO5 Gene

Post-translational modifications for FBXO5 Gene

  • Phosphorylation by CDK2 and subsequently by PLK1 triggers degradation during early mitosis through ubiquitin-mediated proteolysis by the SCF ubiquitin ligase complex containing the F-box protein BTRC. This degradation is necessary for the activation of APC in late mitosis and subsequent mitotic progression.
  • Ubiquitinated by the by the SCF(BTRC) complex following phosphorylation by PLK1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO5 Gene

Domains & Families for FBXO5 Gene

Gene Families for FBXO5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO5 Gene


Suggested Antigen Peptide Sequences for FBXO5 Gene

Graphical View of Domain Structure for InterPro Entry



  • The C-terminal region is required for inhibition of APC activity.
  • The C-terminal region is required for inhibition of APC activity.
genes like me logo Genes that share domains with FBXO5: view

Function for FBXO5 Gene

Molecular function for FBXO5 Gene

UniProtKB/Swiss-Prot Function:
Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.

Gene Ontology (GO) - Molecular Function for FBXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11988738
GO:0019901 protein kinase binding IPI 15148369
GO:0046872 metal ion binding IEA --
GO:1990948 ubiquitin ligase inhibitor activity IDA 15148369
genes like me logo Genes that share ontologies with FBXO5: view
genes like me logo Genes that share phenotypes with FBXO5: view

Animal Models for FBXO5 Gene

MGI Knock Outs for FBXO5:

Animal Model Products

Clone Products

  • Addgene plasmids for FBXO5

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO5 Gene

Localization for FBXO5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO5 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FBXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 11988738
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 11988738
GO:0005819 spindle IEA,IDA 15469984
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXO5: view

Pathways & Interactions for FBXO5 Gene

genes like me logo Genes that share pathways with FBXO5: view

Pathways by source for FBXO5 Gene

SIGNOR curated interactions for FBXO5 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FBXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0001556 oocyte maturation IEA --
GO:0007049 cell cycle IEA --
GO:0007057 spindle assembly involved in female meiosis I IEA --
GO:0007088 regulation of mitotic nuclear division IBA --
genes like me logo Genes that share ontologies with FBXO5: view

Drugs & Compounds for FBXO5 Gene

No Compound Related Data Available

Transcripts for FBXO5 Gene

mRNA/cDNA for FBXO5 Gene

Unigene Clusters for FBXO5 Gene

F-box protein 5:
Representative Sequences:

Clone Products

  • Addgene plasmids for FBXO5

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO5 Gene

No ASD Table

Relevant External Links for FBXO5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXO5 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO5 Gene:


SOURCE GeneReport for Unigene cluster for FBXO5 Gene:

genes like me logo Genes that share expression patterns with FBXO5: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO5 Gene

Orthologs for FBXO5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXO5 34 33
  • 99.78 (n)
(Canis familiaris)
Mammalia FBXO5 34 33
  • 86.67 (n)
(Bos Taurus)
Mammalia FBXO5 34
  • 81 (a)
(Mus musculus)
Mammalia Fbxo5 16 34 33
  • 75.69 (n)
(Rattus norvegicus)
Mammalia Fbxo5 33
  • 73.78 (n)
(Monodelphis domestica)
Mammalia FBXO5 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 55 (a)
-- 34
  • 50 (a)
(Gallus gallus)
Aves FBXO5 34 33
  • 62.17 (n)
(Anolis carolinensis)
Reptilia FBXO5 34
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo5 33
  • 56.31 (n)
(Danio rerio)
Actinopterygii fbxo5 34 33
  • 46.37 (n)
Species where no ortholog for FBXO5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO5 Gene

Gene Tree for FBXO5 (if available)
Gene Tree for FBXO5 (if available)
Evolutionary constrained regions (ECRs) for FBXO5: view image

Paralogs for FBXO5 Gene

Paralogs for FBXO5 Gene

genes like me logo Genes that share paralogs with FBXO5: view

Variants for FBXO5 Gene

Sequence variations from dbSNP and Humsavar for FBXO5 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000530212 -- 152,985,100(-) G/C upstream_transcript_variant
rs1000583458 -- 152,979,244(-) G/A intron_variant
rs1000770116 -- 152,972,556(-) G/T intron_variant
rs1000859209 -- 152,984,815(-) T/G upstream_transcript_variant
rs1000936503 -- 152,971,707(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO5 Gene

Variant ID Type Subtype PubMed ID
esv24301 CNV gain 19812545
nsv1150330 CNV insertion 26484159

Variation tolerance for FBXO5 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO5 Gene

Disorders for FBXO5 Gene

Additional Disease Information for FBXO5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FBXO5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO5 Gene

Publications for FBXO5 Gene

  1. Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. (PMID: 15148369) Moshe Y … Hershko A (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 22 58
  2. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). (PMID: 11988738) Hsu JY … Jackson PK (Nature cell biology 2002) 3 4 22 58
  3. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 58
  4. Polymorphisms in predicted miRNA binding sites and osteoporosis. (PMID: 20641033) Lei SF … Deng HW (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011) 3 44 58
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58

Products for FBXO5 Gene

Sources for FBXO5 Gene

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