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Aliases for TTLL3 Gene

Aliases for TTLL3 Gene

  • Tubulin Tyrosine Ligase Like 3 2 3 5
  • Tubulin--Tyrosine Ligase-Like Protein 3 3 4
  • HOTTL 3 4
  • Tubulin Tyrosine Ligase-Like Family, Member 3 3
  • Tubulin Tyrosine Ligase-Like Family Member 3 2
  • Tubulin Monoglycylase TTLL3 3
  • EC 6.3.2.- 4

External Ids for TTLL3 Gene

Previous GeneCards Identifiers for TTLL3 Gene

  • GC03P009836
  • GC03P009810
  • GC03P009811
  • GC03P009749
  • GC03P009813
  • GC03P009850
  • GC03P009788
  • GC03P009851

Summaries for TTLL3 Gene

GeneCards Summary for TTLL3 Gene

TTLL3 (Tubulin Tyrosine Ligase Like 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-glycine ligase activity and protein-glycine ligase activity, initiating. An important paralog of this gene is ARPC4-TTLL3.

UniProtKB/Swiss-Prot for TTLL3 Gene

  • Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.

Gene Wiki entry for TTLL3 Gene

Additional gene information for TTLL3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL3 Gene

Genomics for TTLL3 Gene

GeneHancer (GH) Regulatory Elements for TTLL3 Gene

Promoters and enhancers for TTLL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J009807 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 672.4 +1.4 1401 3.6 HDGF PKNOX1 SIN3A BMI1 ZBTB7B RAD21 ZNF335 POLR2B SCRT2 ZNF416 TTLL3 EMC3-AS1 BRPF1 TADA3 SETD5 ENSG00000269886 ARPC4 ARPC4-TTLL3
GH03J009835 Promoter 0.8 EPDnew 650.3 +27.3 27267 0.1 TCF12 SKI TFAP4 NR2F1 TCF7 BCL6 TTLL3 GC03M009840 PIR36573 PIR57125 ARPC4-TTLL3 GC03M009835
GH03J009818 Promoter 0.7 EPDnew 664.2 +10.8 10829 0.1 ZFHX2 EGR1 EGR2 TTLL3 PIR57125 PIR45969 GC03P009820 GC03M009818 ARPC4-TTLL3
GH03J009806 Promoter 0.6 EPDnew 650.7 -1.3 -1298 0.1 POLR2A TTLL3 ARPC4 TADA3 ARPC4-TTLL3
GH03J009808 Promoter 0.6 EPDnew 650.7 -1.1 -1055 0.1 POLR2A TTLL3 ARPC4 TADA3 ARPC4-TTLL3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTLL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTLL3 gene promoter:
  • p300
  • NF-1
  • HEN1
  • SEF-1 (1)
  • AREB6
  • TGIF
  • E2F-1
  • E2F
  • COMP1

Genomic Locations for TTLL3 Gene

Genomic Locations for TTLL3 Gene
chr3:9,808,086-9,855,138
(GRCh38/hg38)
Size:
47,053 bases
Orientation:
Plus strand
chr3:9,849,770-9,896,822
(GRCh37/hg19)
Size:
47,053 bases
Orientation:
Plus strand

Genomic View for TTLL3 Gene

Genes around TTLL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL3 Gene

Proteins for TTLL3 Gene

  • Protein details for TTLL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4R7-TTLL3_HUMAN
    Recommended name:
    Tubulin monoglycylase TTLL3
    Protein Accession:
    Q9Y4R7
    Secondary Accessions:
    • Q4KMS8
    • Q6AWA3
    • Q6ZU95
    • Q8NDN8
    • Q96GG8
    • Q9H876
    • Q9UI99

    Protein attributes for TTLL3 Gene

    Size:
    772 amino acids
    Molecular mass:
    87414 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTLL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL3 Gene

Post-translational modifications for TTLL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Boster Bio Antibodies for TTLL3
  • Santa Cruz Biotechnology (SCBT) Antibodies for TTLL3

No data available for DME Specific Peptides for TTLL3 Gene

Domains & Families for TTLL3 Gene

Gene Families for TTLL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TTLL3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TTLL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTLL3: view

No data available for UniProtKB/Swiss-Prot for TTLL3 Gene

Function for TTLL3 Gene

Molecular function for TTLL3 Gene

UniProtKB/Swiss-Prot Function:
Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.

Enzyme Numbers (IUBMB) for TTLL3 Gene

Phenotypes From GWAS Catalog for TTLL3 Gene

Gene Ontology (GO) - Molecular Function for TTLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0070735 protein-glycine ligase activity IEA,TAS --
GO:0070736 protein-glycine ligase activity, initiating ISS --
genes like me logo Genes that share ontologies with TTLL3: view
genes like me logo Genes that share phenotypes with TTLL3: view

Animal Models for TTLL3 Gene

MGI Knock Outs for TTLL3:
  • Ttll3 Ttll3<tm1a(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for TTLL3

miRNA for TTLL3 Gene

miRTarBase miRNAs that target TTLL3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TTLL3 Gene

Localization for TTLL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL3 Gene

Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTLL3 gene
Compartment Confidence
cytoskeleton 5
cytosol 4

Gene Ontology (GO) - Cellular Components for TTLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005929 cilium ISS --
genes like me logo Genes that share ontologies with TTLL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TTLL3 Gene

Pathways & Interactions for TTLL3 Gene

SuperPathways for TTLL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
GO:0018094 protein polyglycylation IEA,TAS --
GO:0035082 axoneme assembly ISS --
GO:0060271 cilium assembly ISS --
genes like me logo Genes that share ontologies with TTLL3: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL3 Gene

Drugs & Compounds for TTLL3 Gene

(1) Drugs for TTLL3 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Theophylline Approved Pharma Antagonist, Target 67
genes like me logo Genes that share compounds with TTLL3: view

Transcripts for TTLL3 Gene

mRNA/cDNA for TTLL3 Gene

Unigene Clusters for TTLL3 Gene

Tubulin tyrosine ligase-like family, member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL3 Gene

No ASD Table

Relevant External Links for TTLL3 Gene

GeneLoc Exon Structure for
TTLL3
ECgene alternative splicing isoforms for
TTLL3

Expression for TTLL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTLL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TTLL3 Gene

This gene is overexpressed in Platelet (62.1) and Adipocyte (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTLL3 Gene



Protein tissue co-expression partners for TTLL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTLL3 Gene:

TTLL3

SOURCE GeneReport for Unigene cluster for TTLL3 Gene:

Hs.726435

Evidence on tissue expression from TISSUES for TTLL3 Gene

  • Thyroid gland(4)
  • Nervous system(4)
  • Lung(3)
genes like me logo Genes that share expression patterns with TTLL3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTLL3 Gene

Orthologs for TTLL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTLL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTLL3 33
  • 99.16 (n)
-- 34
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ttll3 16 34 33
  • 81.51 (n)
rat
(Rattus norvegicus)
Mammalia Ttll3 33
  • 81.36 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 73 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 44 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 54 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ttll3 34
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta TTLL3B 34
  • 23 (a)
ManyToMany
TTLL3A 34
  • 23 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 34
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
OneToMany
Species where no ortholog for TTLL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTLL3 Gene

ENSEMBL:
Gene Tree for TTLL3 (if available)
TreeFam:
Gene Tree for TTLL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TTLL3: view image

Paralogs for TTLL3 Gene

(2) SIMAP similar genes for TTLL3 Gene using alignment to 23 proteins:

  • TTLL3_HUMAN
  • C9IZU0_HUMAN
  • C9JKU2_HUMAN
  • C9JNK2_HUMAN
  • C9JNK7_HUMAN
  • C9JQ30_HUMAN
  • C9JRM2_HUMAN
  • C9JSD3_HUMAN
  • C9JUK0_HUMAN
  • C9JW59_HUMAN
  • C9JWZ9_HUMAN
  • C9JZ73_HUMAN
  • E5RGZ6_HUMAN
  • F8WBP6_HUMAN
  • F8WD18_HUMAN
  • H0Y5E3_HUMAN
  • H3BLT7_HUMAN
  • H7C0T5_HUMAN
  • H7C197_HUMAN
  • J3KQB2_HUMAN
  • R4GMR7_HUMAN
  • R4GMW2_HUMAN
  • R4GN12_HUMAN
genes like me logo Genes that share paralogs with TTLL3: view

Variants for TTLL3 Gene

Sequence variations from dbSNP and Humsavar for TTLL3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
VAR_036054 A colorectal cancer sample p.Gly454Ser
VAR_036055 A colorectal cancer sample p.Met476Ile
rs1000014508 -- 9,816,365(+) T/C intron_variant
rs1000075445 -- 9,818,378(+) T/G intron_variant
rs1000147122 -- 9,819,896(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TTLL3 Gene

Variant ID Type Subtype PubMed ID
esv3342578 CNV duplication 20981092
esv3595249 CNV gain 21293372
nsv1010768 CNV gain 25217958
nsv237238 CNV deletion 16902084
nsv819644 CNV gain 19587683
nsv834615 CNV loss 17160897

Variation tolerance for TTLL3 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.09; 75.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTLL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTLL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL3 Gene

Disorders for TTLL3 Gene

Additional Disease Information for TTLL3

No disorders were found for TTLL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL3 Gene

Publications for TTLL3 Gene

  1. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. (PMID: 19524510) Rogowski K … Janke C (Cell 2009) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1. (PMID: 11054573) Trichet V … De Sario A (Gene 2000) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J … Colwill K (Science signaling 2015) 3 58

Products for TTLL3 Gene

Sources for TTLL3 Gene

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