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Aliases for ANKRD17 Gene

Aliases for ANKRD17 Gene

  • Ankyrin Repeat Domain 17 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-16 3 4
  • Gene Trap Ankyrin Repeat Protein 3 4
  • GTAR 3 4
  • Ankyrin Repeat Domain-Containing Protein 17 3
  • NY-BR-16 3
  • KIAA0697 4
  • MASK2 3

External Ids for ANKRD17 Gene

Previous GeneCards Identifiers for ANKRD17 Gene

  • GC04M074407
  • GC04M074406
  • GC04M074305
  • GC04M074159
  • GC04M073940
  • GC04M069746

Summaries for ANKRD17 Gene

Entrez Gene Summary for ANKRD17 Gene

  • The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

GeneCards Summary for ANKRD17 Gene

ANKRD17 (Ankyrin Repeat Domain 17) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ANKHD1-EIF4EBP3.

UniProtKB/Swiss-Prot for ANKRD17 Gene

  • Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).

Gene Wiki entry for ANKRD17 Gene

Additional gene information for ANKRD17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD17 Gene

Genomics for ANKRD17 Gene

GeneHancer (GH) Regulatory Elements for ANKRD17 Gene

Promoters and enhancers for ANKRD17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J073255 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.8 792 4.9 HDGF PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 ANKRD17 ENSG00000250220 LOC102724832 GC04P073141
GH04J073221 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 661.7 +36.4 36350 2.6 PKNOX1 ATF1 FOXA2 SMAD1 ARNT SIN3A FEZF1 YY1 POLR2B E2F8 ANKRD17 ENSG00000250220 ENSG00000221639 LOC102724832 GC04P073141
GH04J074097 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 25.1 -840.0 -840047 4 HDGF PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 CXCL2 ANKRD17 ENSG00000250220 CXCL3 AREG MTHFD2L LOC643014
GH04J073066 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 +190.5 190465 5 HDGF FOXA2 PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 COX18 ENSG00000221639 ENSG00000250220 ANKRD17 RNU6ATAC5P
GH04J073702 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.4 -445.6 -445556 3.8 PKNOX1 ATF1 ARNT FEZF1 YY1 TCF12 POLR2B ZNF766 E2F8 FOS CXCL8 CXCL2 CXCL3 ANKRD17 HMGA1P2 PF4V1 LOC105377272 CXCL5 MTHFD2L CXCL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD17 gene promoter:
  • MAZR
  • FOXL1
  • AML1a
  • SEF-1 (1)
  • COUP-TF1
  • HNF-4alpha2
  • HNF-4alpha1
  • COUP-TF
  • COUP
  • CREB

Genomic Locations for ANKRD17 Gene

Genomic Locations for ANKRD17 Gene
chr4:73,073,376-73,259,142
(GRCh38/hg38)
Size:
185,767 bases
Orientation:
Minus strand
chr4:73,939,093-74,124,515
(GRCh37/hg19)
Size:
185,423 bases
Orientation:
Minus strand

Genomic View for ANKRD17 Gene

Genes around ANKRD17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD17 Gene

Proteins for ANKRD17 Gene

  • Protein details for ANKRD17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75179-ANR17_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 17
    Protein Accession:
    O75179
    Secondary Accessions:
    • E7EUV3
    • G5E964
    • Q6PJ85
    • Q6PK85
    • Q6PKA2
    • Q86XI3
    • Q8NDR5
    • Q96I86
    • Q9H288
    • Q9H6J9

    Protein attributes for ANKRD17 Gene

    Size:
    2603 amino acids
    Molecular mass:
    274258 Da
    Quaternary structure:
    • Interacts with VP1 capsid protein of enterovirus 71 (EV71). Interacts (via N-terminus) with NOD2. Interacts with CDK2, MCM3, MCM5, MCM7, CDC6 and PCNA. Interacts with MAVS and IFIH1. Interacts (via the second ankyrin repeat cluster) with DDX58.
    SequenceCaution:
    • Sequence=AAG48253.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAH04173.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB15260.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15260.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD17 Gene

neXtProt entry for ANKRD17 Gene

Post-translational modifications for ANKRD17 Gene

No data available for DME Specific Peptides for ANKRD17 Gene

Domains & Families for ANKRD17 Gene

Gene Families for ANKRD17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD17: view

No data available for UniProtKB/Swiss-Prot for ANKRD17 Gene

Function for ANKRD17 Gene

Molecular function for ANKRD17 Gene

UniProtKB/Swiss-Prot Function:
Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).

Phenotypes From GWAS Catalog for ANKRD17 Gene

Gene Ontology (GO) - Molecular Function for ANKRD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003682 chromatin binding IDA 19150984
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IEA,IPI 19150984
genes like me logo Genes that share ontologies with ANKRD17: view
genes like me logo Genes that share phenotypes with ANKRD17: view

Animal Models for ANKRD17 Gene

MGI Knock Outs for ANKRD17:

Animal Model Products

  • Taconic Biosciences Mouse Models for ANKRD17

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANKRD17 Gene

Localization for ANKRD17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD17 Gene

Cytoplasm. Nucleus. Note=Detected around the nucleolus. Localized on chromatin in a cell cycle-dependent manner. {ECO:0000269 PubMed:17276651, ECO:0000269 PubMed:19150984}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD17 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 3
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANKRD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 19150984
GO:0005634 nucleus IEA,IDA 19150984
GO:0005737 cytoplasm IDA,IEA 22328336
GO:0016020 membrane HDA 19946888
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with ANKRD17: view

Pathways & Interactions for ANKRD17 Gene

SuperPathways for ANKRD17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001955 blood vessel maturation IEA --
GO:0002376 immune system process IEA --
GO:0006275 regulation of DNA replication IMP 19150984
GO:0016032 viral process IEA --
GO:0042742 defense response to bacterium IDA 23711367
genes like me logo Genes that share ontologies with ANKRD17: view

No data available for Pathways by source and SIGNOR curated interactions for ANKRD17 Gene

Drugs & Compounds for ANKRD17 Gene

No Compound Related Data Available

Transcripts for ANKRD17 Gene

mRNA/cDNA for ANKRD17 Gene

Unigene Clusters for ANKRD17 Gene

Ankyrin repeat domain 17:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD17 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: -
SP2:
SP3: - -
SP4: -
SP5: - -
SP6: - - - - - - - - - - - -

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35a · 35b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - - - - - - - - -

Relevant External Links for ANKRD17 Gene

GeneLoc Exon Structure for
ANKRD17
ECgene alternative splicing isoforms for
ANKRD17

Expression for ANKRD17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD17 Gene

This gene is overexpressed in Lung (18.9), Platelet (15.4), Retina (8.4), and Fetal Brain (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANKRD17 Gene



Protein tissue co-expression partners for ANKRD17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD17 Gene:

ANKRD17

SOURCE GeneReport for Unigene cluster for ANKRD17 Gene:

Hs.601206

mRNA Expression by UniProt/SwissProt for ANKRD17 Gene:

O75179-ANR17_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for ANKRD17 Gene

  • Nervous system(4.9)
  • Liver(4.3)
  • Muscle(4.3)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with ANKRD17: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD17 Gene

Orthologs for ANKRD17 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD17 34 33
  • 99.81 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD17 34 33
  • 96.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD17 34 33
  • 95.61 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd17 16 34 33
  • 92.9 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd17 33
  • 92.29 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD17 34
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD17 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD17 34 33
  • 84.48 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD17 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd17 33
  • 76.43 (n)
Str.15599 33
fruit fly
(Drosophila melanogaster)
Insecta mask 34
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 69 (a)
OneToMany
Cin.13317 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13317 33
Species where no ortholog for ANKRD17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANKRD17 Gene

ENSEMBL:
Gene Tree for ANKRD17 (if available)
TreeFam:
Gene Tree for ANKRD17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD17: view image

Paralogs for ANKRD17 Gene

(14) SIMAP similar genes for ANKRD17 Gene using alignment to 5 proteins:

  • ANR17_HUMAN
  • E7EUV3_HUMAN
  • H0YLQ3_HUMAN
  • H0YM23_HUMAN
  • H0YMS3_HUMAN
genes like me logo Genes that share paralogs with ANKRD17: view

Variants for ANKRD17 Gene

Sequence variations from dbSNP and Humsavar for ANKRD17 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs2306058 association, Lip and oral cavity carcinoma 73,076,961(-) C/T coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant
rs1000023133 -- 73,177,997(-) C/T intron_variant
rs1000028889 -- 73,220,013(-) T/C intron_variant
rs1000040193 -- 73,110,467(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000050398 -- 73,252,783(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD17 Gene

Variant ID Type Subtype PubMed ID
esv3600984 CNV gain 21293372
esv3600985 CNV gain 21293372
esv3600989 CNV loss 21293372
esv3600990 CNV loss 21293372
esv3600991 CNV loss 21293372
nsv1000509 CNV gain 25217958
nsv523169 CNV gain 19592680
nsv966284 CNV duplication 23825009

Variation tolerance for ANKRD17 Gene

Residual Variation Intolerance Score: 0.175% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD17 Gene

Disorders for ANKRD17 Gene

Additional Disease Information for ANKRD17

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ANKRD17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD17 Gene

Publications for ANKRD17 Gene

  1. Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17. (PMID: 19150984) Deng M … Ye X (The Journal of biological chemistry 2009) 3 4 22 58
  2. A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses. (PMID: 23711367) Menning M … Kufer TA (FEBS letters 2013) 3 4 58
  3. Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling. (PMID: 22328336) Wang Y … Ye X (European journal of immunology 2012) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. The VP1 structural protein of enterovirus 71 interacts with human ornithine decarboxylase and gene trap ankyrin repeat. (PMID: 17276651) Yeo WM … Chow VT (Microbial pathogenesis 2007) 3 4 58

Products for ANKRD17 Gene

Sources for ANKRD17 Gene

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