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Aliases for SLITRK5 Gene

Aliases for SLITRK5 Gene

  • SLIT And NTRK Like Family Member 5 2 3 5
  • Leucine-Rich Repeat-Containing Protein 11 3 4
  • Leucine Rich Repeat Containing 11 2 3
  • LRRC11 3 4
  • SLIT And NTRK-Like Family, Member 5 2
  • SLIT And NTRK-Like Protein 5 3
  • Slit And Trk Like Gene 5 3
  • BA364G4.2 3
  • KIAA0918 4

External Ids for SLITRK5 Gene

Previous HGNC Symbols for SLITRK5 Gene

  • LRRC11

Previous GeneCards Identifiers for SLITRK5 Gene

  • GC13P086022
  • GC13P087122
  • GC13P088324
  • GC13P068910

Summaries for SLITRK5 Gene

Entrez Gene Summary for SLITRK5 Gene

  • Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLITRK5 Gene

SLITRK5 (SLIT And NTRK Like Family Member 5) is a Protein Coding gene. Diseases associated with SLITRK5 include Trichotillomania and Obsessive-Compulsive Disorder. An important paralog of this gene is SLITRK2.

UniProtKB/Swiss-Prot for SLITRK5 Gene

  • Suppresses neurite outgrowth.

Gene Wiki entry for SLITRK5 Gene

Additional gene information for SLITRK5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLITRK5 Gene

Genomics for SLITRK5 Gene

GeneHancer (GH) Regulatory Elements for SLITRK5 Gene

Promoters and enhancers for SLITRK5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J087670 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 +0.9 914 3 PKNOX1 ZSCAN4 SIN3A ZNF48 RAD21 RFX5 YY1 GLIS2 ELK1 ZNF366 MIR4500HG SLITRK5 NUDT21P1
GH13J087673 Enhancer 0.5 ENCODE 0.7 +2.8 2769 0.2 MXI1 POLR2A L3MBTL2 ZNF547 ZSCAN4 EZH2 MIR4500HG SLITRK5 NUDT21P1
GH13J087674 Enhancer 0.5 ENCODE 0.7 +2.5 2474 0 MXI1 POLR2A L3MBTL2 EZH2 MIR4500HG SLITRK5 NUDT21P1
GH13J087676 Enhancer 0.7 Ensembl ENCODE 0.4 +6.0 6002 1.9 L3MBTL2 MAX MNT EZH2 SLITRK5 MIR4500HG NUDT21P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLITRK5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLITRK5 gene promoter:
  • Chx10
  • NF-1
  • C/EBPalpha
  • HOXA5
  • GATA-1
  • CBF-A
  • CBF(2)
  • CBF-B
  • CP1A

Genomic Locations for SLITRK5 Gene

Genomic Locations for SLITRK5 Gene
25,041 bases
Plus strand
7,002 bases
Plus strand

Genomic View for SLITRK5 Gene

Genes around SLITRK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLITRK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLITRK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLITRK5 Gene

Proteins for SLITRK5 Gene

  • Protein details for SLITRK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SLIT and NTRK-like protein 5
    Protein Accession:
    Secondary Accessions:
    • B3KNB8
    • B4DSH5
    • Q5VT81

    Protein attributes for SLITRK5 Gene

    958 amino acids
    Molecular mass:
    107486 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA74941.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLITRK5 Gene


neXtProt entry for SLITRK5 Gene

Post-translational modifications for SLITRK5 Gene

  • Glycosylation at posLast=644644, posLast=366366, and isoforms=103
  • Modification sites at PhosphoSitePlus

Other Protein References for SLITRK5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLITRK5 Gene

Domains & Families for SLITRK5 Gene

Gene Families for SLITRK5 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLITRK family.
  • Belongs to the SLITRK family.
genes like me logo Genes that share domains with SLITRK5: view

Function for SLITRK5 Gene

Molecular function for SLITRK5 Gene

UniProtKB/Swiss-Prot Function:
Suppresses neurite outgrowth.
genes like me logo Genes that share phenotypes with SLITRK5: view

Animal Models for SLITRK5 Gene

MGI Knock Outs for SLITRK5:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLITRK5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLITRK5 Gene

Localization for SLITRK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLITRK5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLITRK5 gene
Compartment Confidence
plasma membrane 5
nucleus 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLITRK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with SLITRK5: view

Pathways & Interactions for SLITRK5 Gene

SuperPathways for SLITRK5 Gene

No Data Available

Interacting Proteins for SLITRK5 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins: ENSP00000366283 O94991-SLIK5_HUMAN for SLITRK5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLITRK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 chemical synaptic transmission IEA --
GO:0007409 axonogenesis IBA,IEA --
GO:0007625 grooming behavior IEA --
GO:0009410 response to xenobiotic stimulus IEA --
GO:0021756 striatum development IEA --
genes like me logo Genes that share ontologies with SLITRK5: view

No data available for Pathways by source and SIGNOR curated interactions for SLITRK5 Gene

Drugs & Compounds for SLITRK5 Gene

No Compound Related Data Available

Transcripts for SLITRK5 Gene

mRNA/cDNA for SLITRK5 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLITRK5 Gene

SLIT and NTRK-like family, member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLITRK5 Gene

No ASD Table

Relevant External Links for SLITRK5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLITRK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLITRK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLITRK5 Gene

This gene is overexpressed in Brain - Cortex (x6.4), Brain - Frontal Cortex (BA9) (x6.4), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for SLITRK5 Gene

This gene is overexpressed in Prostate (32.9), Cardia (12.6), Heart (12.0), and Ovary (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLITRK5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLITRK5 Gene:


SOURCE GeneReport for Unigene cluster for SLITRK5 Gene:


mRNA Expression by UniProt/SwissProt for SLITRK5 Gene:

Tissue specificity: Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla.

Evidence on tissue expression from TISSUES for SLITRK5 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SLITRK5: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLITRK5 Gene

Orthologs for SLITRK5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLITRK5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLITRK5 34 33
  • 99.69 (n)
(Monodelphis domestica)
Mammalia SLITRK5 34
  • 94 (a)
(Canis familiaris)
Mammalia SLITRK5 34 33
  • 93.77 (n)
(Bos Taurus)
Mammalia SLITRK5 34 33
  • 91.78 (n)
(Mus musculus)
Mammalia Slitrk5 16 34 33
  • 90.34 (n)
(Rattus norvegicus)
Mammalia Slitrk5 33
  • 90.31 (n)
(Ornithorhynchus anatinus)
Mammalia SLITRK5 34
  • 89 (a)
(Gallus gallus)
Aves SLITRK5 34 33
  • 79.67 (n)
(Anolis carolinensis)
Reptilia SLITRK5 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slitrk5 33
  • 72.76 (n)
(Danio rerio)
Actinopterygii SLITRK5 (2 of 2) 34
  • 70 (a)
LOC101882841 33
  • 67.68 (n)
slitrk5b 34
  • 57 (a)
Dr.16352 33
fruit fly
(Drosophila melanogaster)
Insecta sli 34
  • 11 (a)
(Caenorhabditis elegans)
Secernentea slt-1 34
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 18 (a)
Species where no ortholog for SLITRK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLITRK5 Gene

Gene Tree for SLITRK5 (if available)
Gene Tree for SLITRK5 (if available)
Evolutionary constrained regions (ECRs) for SLITRK5: view image

Paralogs for SLITRK5 Gene

Paralogs for SLITRK5 Gene

(7) SIMAP similar genes for SLITRK5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLITRK5: view

Variants for SLITRK5 Gene

Sequence variations from dbSNP and Humsavar for SLITRK5 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1060499750 likely-pathogenic, Abnormality of brain morphology 87,677,903(+) G/C coding_sequence_variant, missense_variant
rs1000212859 -- 87,671,166(+) T/C upstream_transcript_variant
rs1000486817 -- 87,672,887(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000553700 -- 87,671,947(+) A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000583114 -- 87,672,156(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLITRK5 Gene

Variant ID Type Subtype PubMed ID
nsv1044071 CNV loss 25217958
nsv1112636 CNV deletion 24896259

Variation tolerance for SLITRK5 Gene

Residual Variation Intolerance Score: 4.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLITRK5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLITRK5 Gene

Disorders for SLITRK5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLITRK5 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • ttm
obsessive-compulsive disorder
  • ocd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLITRK5

genes like me logo Genes that share disorders with SLITRK5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLITRK5 Gene

Publications for SLITRK5 Gene

  1. Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. (PMID: 14557068) Aruga J … Mikoshiba K (Gene 2003) 2 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SLITRK5 Gene

Sources for SLITRK5 Gene

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