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Aliases for LRP10 Gene

Aliases for LRP10 Gene

  • LDL Receptor Related Protein 10 2 3 5
  • LRP-10 3 4
  • Low-Density Lipoprotein Receptor-Related Protein 10 3
  • Low Density Lipoprotein Receptor-Related Protein 10 2
  • MSTP087 3
  • MST087 3
  • LRP9 3

External Ids for LRP10 Gene

Previous GeneCards Identifiers for LRP10 Gene

  • GC14P020717
  • GC14P017128
  • GC14P021331
  • GC14P022410
  • GC14P023340
  • GC14P003458

Summaries for LRP10 Gene

Entrez Gene Summary for LRP10 Gene

  • This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]

GeneCards Summary for LRP10 Gene

LRP10 (LDL Receptor Related Protein 10) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of fat-soluble vitamins. An important paralog of this gene is LRP12.

UniProtKB/Swiss-Prot for LRP10 Gene

  • Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).

Gene Wiki entry for LRP10 Gene

Additional gene information for LRP10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP10 Gene

Genomics for LRP10 Gene

GeneHancer (GH) Regulatory Elements for LRP10 Gene

Promoters and enhancers for LRP10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J022869 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.1 68 3.7 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 NFYC LRP10 ACIN1 RBM23 HAUS4 C14orf93 PRMT5 LOC102724814 MMP14 NGDN OXA1L
GH14J022875 Promoter 0.5 EPDnew 650.7 +3.5 3536 0.1 LRP10 PIR52217 GC14P024322
GH14J022844 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -22.3 -22332 9.9 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 PIR54043 NGDN LRP10 REM2 OXA1L PABPN1 RBM23 DAD1 PRMT5-AS1 THTPA
GH14J023093 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.8 +223.7 223653 3.3 ZFP64 DMAP1 YBX1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC PPARGC1A ACIN1 C14orf119 RBM23 PRMT5 OXA1L LOC102724814 HAUS4 C14orf93 NGDN BCL2L2-PABPN1
GH14J023056 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.8 +186.0 185984 3 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 SLC30A9 ZNF213 ZNF143 SP3 CDH24 LOC105370705 ACIN1 NGDN RBM23 PRMT5 C14orf93 MMP14 LOC102724814 HAUS4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRP10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRP10 gene promoter:
  • NF-1/L
  • NF-1
  • ATF
  • ZID
  • Pax-4a
  • HTF
  • E47
  • Hand1
  • AML1a

Genomic Locations for LRP10 Gene

Genomic Locations for LRP10 Gene
chr14:22,871,613-22,881,580
(GRCh38/hg38)
Size:
9,968 bases
Orientation:
Plus strand
chr14:23,340,822-23,350,789
(GRCh37/hg19)
Size:
9,968 bases
Orientation:
Plus strand

Genomic View for LRP10 Gene

Genes around LRP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP10 Gene

Proteins for LRP10 Gene

  • Protein details for LRP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4F1-LRP10_HUMAN
    Recommended name:
    Low-density lipoprotein receptor-related protein 10
    Protein Accession:
    Q7Z4F1
    Secondary Accessions:
    • A8K4R5
    • D3DS31
    • O95882
    • Q14CK7
    • Q86T02
    • Q8NCZ4
    • Q9HC42
    • Q9UG33

    Protein attributes for LRP10 Gene

    Size:
    713 amino acids
    Molecular mass:
    76193 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD20037.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG17980.1; Type=Frameshift; Positions=370, 700; Evidence={ECO:0000305}; Sequence=AAQ13610.1; Type=Frameshift; Positions=312, 337, 496, 502, 512; Evidence={ECO:0000305}; Sequence=CAD39174.2; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRP10 Gene

Post-translational modifications for LRP10 Gene

  • Glycosylation at isoforms=2299, isoforms=2193, posLast=111111, and isoforms=256
  • Modification sites at PhosphoSitePlus

Other Protein References for LRP10 Gene

No data available for DME Specific Peptides for LRP10 Gene

Domains & Families for LRP10 Gene

Gene Families for LRP10 Gene

Suggested Antigen Peptide Sequences for LRP10 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4F1

UniProtKB/Swiss-Prot:

LRP10_HUMAN :
  • Belongs to the LDLR family.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LRP10: view

Function for LRP10 Gene

Molecular function for LRP10 Gene

UniProtKB/Swiss-Prot Function:
Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).

Gene Ontology (GO) - Molecular Function for LRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005041 low-density lipoprotein particle receptor activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LRP10: view
genes like me logo Genes that share phenotypes with LRP10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LRP10

miRNA for LRP10 Gene

miRTarBase miRNAs that target LRP10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRP10 Gene

Localization for LRP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP10 Gene

Membrane; Single-pass type I membrane protein. Membrane, coated pit.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRP10 gene
Compartment Confidence
plasma membrane 3
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005905 clathrin-coated pit IEA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRP10: view

Pathways & Interactions for LRP10 Gene

genes like me logo Genes that share pathways with LRP10: view

Interacting Proteins for LRP10 Gene

Gene Ontology (GO) - Biological Process for LRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006869 lipid transport IEA --
GO:0006897 endocytosis IEA --
GO:0006898 receptor-mediated endocytosis IEA --
GO:0048839 inner ear development IEA --
genes like me logo Genes that share ontologies with LRP10: view

No data available for SIGNOR curated interactions for LRP10 Gene

Drugs & Compounds for LRP10 Gene

No Compound Related Data Available

Transcripts for LRP10 Gene

mRNA/cDNA for LRP10 Gene

Unigene Clusters for LRP10 Gene

Low density lipoprotein receptor-related protein 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRP10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
SP1: - -
SP2: -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for LRP10 Gene

GeneLoc Exon Structure for
LRP10
ECgene alternative splicing isoforms for
LRP10

Expression for LRP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRP10 Gene

mRNA differential expression in normal tissues according to GTEx for LRP10 Gene

This gene is overexpressed in Whole Blood (x7.5).

Protein differential expression in normal tissues from HIPED for LRP10 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRP10 Gene



Protein tissue co-expression partners for LRP10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRP10 Gene:

LRP10

SOURCE GeneReport for Unigene cluster for LRP10 Gene:

Hs.525232

mRNA Expression by UniProt/SwissProt for LRP10 Gene:

Q7Z4F1-LRP10_HUMAN
Tissue specificity: Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle and heart.

Evidence on tissue expression from TISSUES for LRP10 Gene

  • Lung(4.8)
  • Nervous system(4.7)
  • Intestine(3.7)
  • Pancreas(3.4)
  • Eye(2.1)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with LRP10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LRP10 Gene

Orthologs for LRP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRP10 34 33
  • 99.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRP10 34 33
  • 87.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LRP10 34 33
  • 87.11 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lrp10 16 34 33
  • 85.95 (n)
rat
(Rattus norvegicus)
Mammalia Lrp10 33
  • 85.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LRP10 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRP10 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRP10 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp10 33
  • 53.17 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5830 33
zebrafish
(Danio rerio)
Actinopterygii LOC560361 33
  • 49.9 (n)
LRP10 34
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ImpE1 34
  • 8 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M03E7.4 34
  • 19 (a)
OneToMany
Species where no ortholog for LRP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRP10 Gene

ENSEMBL:
Gene Tree for LRP10 (if available)
TreeFam:
Gene Tree for LRP10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRP10: view image

Paralogs for LRP10 Gene

Paralogs for LRP10 Gene

(3) SIMAP similar genes for LRP10 Gene using alignment to 5 proteins:

  • LRP10_HUMAN
  • H0YHW7_HUMAN
  • Q5I0F9_HUMAN
  • Q66K21_HUMAN
  • Q6IAK3_HUMAN
genes like me logo Genes that share paralogs with LRP10: view

Variants for LRP10 Gene

Sequence variations from dbSNP and Humsavar for LRP10 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs568022752 uncertain-significance, Exstrophy of the bladder 22,875,702(+) G/A coding_sequence_variant, missense_variant
rs1000268552 -- 22,875,064(+) G/A/C coding_sequence_variant, missense_variant, synonymous_variant
rs1000587796 -- 22,876,543(+) G/C intron_variant
rs1000942014 -- 22,879,681(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1001287870 -- 22,870,323(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LRP10 Gene

Variant ID Type Subtype PubMed ID
nsv1214 CNV deletion 18451855
nsv563998 CNV gain 21841781

Variation tolerance for LRP10 Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRP10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRP10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP10 Gene

Disorders for LRP10 Gene

Additional Disease Information for LRP10

No disorders were found for LRP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRP10 Gene

Publications for LRP10 Gene

  1. A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro. (PMID: 11123907) Sugiyama T … Kitamura T (Biochemistry 2000) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 3 4 58

Products for LRP10 Gene

Sources for LRP10 Gene

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