Aliases for AMBP Gene
External Ids for AMBP Gene
Previous HGNC Symbols for AMBP Gene
Previous GeneCards Identifiers for AMBP Gene
This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for AMBP Gene
AMBP (Alpha-1-Microglobulin/Bikunin Precursor) is a Protein Coding gene. Diseases associated with AMBP include Vesicoureteral Reflux 1 and Hypertensive Nephropathy. Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates and Binding and Uptake of Ligands by Scavenger Receptors. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SPINT1.
UniProtKB/Swiss-Prot for AMBP Gene
Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.
Trypstatin is a trypsin inhibitor.