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Aliases for RASGRP3 Gene

Aliases for RASGRP3 Gene

  • RAS Guanyl Releasing Protein 3 2 3 5
  • Calcium- And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor III 2 3
  • Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor III 3 4
  • RAS Guanyl Releasing Protein 3 (Calcium And DAG-Regulated) 2 3
  • Guanine Nucleotide Exchange Factor For Rap1 3 4
  • GRP3 3 4
  • Ras Guanyl-Releasing Protein 3 3
  • KIAA0846 4

External Ids for RASGRP3 Gene

Previous GeneCards Identifiers for RASGRP3 Gene

  • GC02P033619
  • GC02P033635
  • GC02P033573
  • GC02P033514
  • GC02P033395
  • GC02P033661

Summaries for RASGRP3 Gene

Entrez Gene Summary for RASGRP3 Gene

  • The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]

GeneCards Summary for RASGRP3 Gene

RASGRP3 (RAS Guanyl Releasing Protein 3) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activator activity. An important paralog of this gene is RASGRP1.

UniProtKB/Swiss-Prot for RASGRP3 Gene

  • Guanine nucleotide exchange factor (GEF) for Ras and Rap1.

Gene Wiki entry for RASGRP3 Gene

Additional gene information for RASGRP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGRP3 Gene

Genomics for RASGRP3 Gene

GeneHancer (GH) Regulatory Elements for RASGRP3 Gene

Promoters and enhancers for RASGRP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J033474 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 675.1 +41.5 41502 6.1 PKNOX1 FOXA2 SMAD1 SIN3A FEZF1 IRF4 YY1 ZNF143 JUNB REST RASGRP3 TTC27 LOC105374454
GH02J033436 Enhancer 0.9 Ensembl ENCODE 650.7 +1.3 1266 1.5 HDAC1 MEIS2 ATF1 LEF1 PKNOX1 TEAD4 TAL1 CHAMP1 FOSL1 TCF12 RASGRP3 LOC105374454
GH02J033437 Promoter 0.7 EPDnew 650.7 -0.1 -71 0.1 POLR2A TAF1 RASGRP3 MIR4430
GH02J033438 Promoter 0.7 EPDnew 650.7 +0.0 30 0.1 POLR2A TAF1 RASGRP3 LOC105374454
GH02J033405 Promoter 0.5 EPDnew 661.7 -30.7 -30667 0.1 RASGRP3 MIR4430 PIR50335
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASGRP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RASGRP3 gene promoter:
  • NF-kappaB
  • CUTL1
  • NF-kappaB1
  • MEF-2A
  • aMEF-2
  • STAT5A
  • SRY
  • Sox5
  • SRF
  • SRF (504 AA)

Genomic Locations for RASGRP3 Gene

Genomic Locations for RASGRP3 Gene
128,427 bases
Plus strand
128,427 bases
Plus strand

Genomic View for RASGRP3 Gene

Genes around RASGRP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASGRP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASGRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASGRP3 Gene

Proteins for RASGRP3 Gene

  • Protein details for RASGRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras guanyl-releasing protein 3
    Protein Accession:
    Secondary Accessions:
    • D6W583
    • O94931
    • Q53SD7

    Protein attributes for RASGRP3 Gene

    690 amino acids
    Molecular mass:
    78332 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA74869.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASGRP3 Gene


neXtProt entry for RASGRP3 Gene

Post-translational modifications for RASGRP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RASGRP3 Gene

Domains & Families for RASGRP3 Gene

Gene Families for RASGRP3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RASGRP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RASGRP family.
  • Belongs to the RASGRP family.
genes like me logo Genes that share domains with RASGRP3: view

Function for RASGRP3 Gene

Molecular function for RASGRP3 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for Ras and Rap1.

Phenotypes From GWAS Catalog for RASGRP3 Gene

Gene Ontology (GO) - Molecular Function for RASGRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity TAS --
GO:0005085 guanyl-nucleotide exchange factor activity IEA,TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005096 GTPase activator activity IDA,IEA 10934204
GO:0005509 calcium ion binding NAS 10934204
genes like me logo Genes that share ontologies with RASGRP3: view
genes like me logo Genes that share phenotypes with RASGRP3: view

Animal Models for RASGRP3 Gene

MGI Knock Outs for RASGRP3:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASGRP3 Gene

Localization for RASGRP3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASGRP3 gene
Compartment Confidence
plasma membrane 5
cytosol 2
mitochondrion 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RASGRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10934204
GO:0032045 guanyl-nucleotide exchange factor complex IEA --
genes like me logo Genes that share ontologies with RASGRP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASGRP3 Gene

Pathways & Interactions for RASGRP3 Gene

SuperPathways for RASGRP3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling events of B Cell Receptor (BCR)
3 B cell receptor signaling pathway (KEGG)
4 Ras signaling pathway
5 Developmental Biology
genes like me logo Genes that share pathways with RASGRP3: view

SIGNOR curated interactions for RASGRP3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RASGRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007264 small GTPase mediated signal transduction TAS,IEA 10934204
GO:0007265 Ras protein signal transduction IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043087 regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RASGRP3: view

Drugs & Compounds for RASGRP3 Gene

(3) Drugs for RASGRP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for RASGRP3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group B
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
genes like me logo Genes that share compounds with RASGRP3: view

Transcripts for RASGRP3 Gene

Unigene Clusters for RASGRP3 Gene

RAS guanyl releasing protein 3 (calcium and DAG-regulated):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASGRP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - -
SP9: -

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c
SP1: -
SP2: -
SP3: -

Relevant External Links for RASGRP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASGRP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASGRP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASGRP3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.7).

Protein differential expression in normal tissues from HIPED for RASGRP3 Gene

This gene is overexpressed in Heart (37.4) and Liver (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASGRP3 Gene

Protein tissue co-expression partners for RASGRP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RASGRP3 Gene:


SOURCE GeneReport for Unigene cluster for RASGRP3 Gene:


Evidence on tissue expression from TISSUES for RASGRP3 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with RASGRP3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASGRP3 Gene

Orthologs for RASGRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASGRP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RASGRP3 34 33
  • 99.71 (n)
(Canis familiaris)
Mammalia RASGRP3 34 33
  • 93.81 (n)
(Bos Taurus)
Mammalia RASGRP3 34 33
  • 93.47 (n)
(Mus musculus)
Mammalia Rasgrp3 16 34 33
  • 89.28 (n)
(Monodelphis domestica)
Mammalia RASGRP3 34
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia RASGRP3 34
  • 88 (a)
(Rattus norvegicus)
Mammalia Rasgrp3 33
  • 87.87 (n)
(Gallus gallus)
Aves RASGRP3 34 33
  • 80.49 (n)
(Anolis carolinensis)
Reptilia RASGRP3 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rasgrp3 33
  • 75 (n)
(Danio rerio)
Actinopterygii rasgrp3 34 33
  • 70.5 (n)
(Caenorhabditis elegans)
Secernentea rgef-1 34 33
  • 50.19 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
Species where no ortholog for RASGRP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASGRP3 Gene

Gene Tree for RASGRP3 (if available)
Gene Tree for RASGRP3 (if available)
Evolutionary constrained regions (ECRs) for RASGRP3: view image

Paralogs for RASGRP3 Gene

(5) SIMAP similar genes for RASGRP3 Gene using alignment to 7 proteins:

  • C9J9C9_HUMAN
  • C9K0P4_HUMAN
  • H7C352_HUMAN
genes like me logo Genes that share paralogs with RASGRP3: view

Variants for RASGRP3 Gene

Sequence variations from dbSNP and Humsavar for RASGRP3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs2124437 association, Lip and oral cavity carcinoma 33,457,670(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000023781 -- 33,505,946(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000047483 -- 33,541,544(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000053257 -- 33,506,283(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000101726 -- 33,439,712(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RASGRP3 Gene

Variant ID Type Subtype PubMed ID
dgv1885n106 CNV deletion 24896259
dgv444n27 CNV loss 19166990
dgv6755n54 CNV loss 21841781
dgv6756n54 CNV loss 21841781
dgv684e214 CNV loss 21293372
esv2199255 CNV deletion 18987734
esv2462414 CNV deletion 19546169
esv2661374 CNV deletion 23128226
esv2719890 CNV deletion 23290073
esv2762447 CNV gain 21179565
esv28690 CNV gain+loss 19812545
esv3554711 CNV deletion 23714750
esv3583713 CNV loss 25503493
esv3590286 CNV loss 21293372
esv3590288 CNV loss 21293372
esv3590289 CNV loss 21293372
esv3590291 CNV gain 21293372
esv3590295 CNV loss 21293372
esv3891725 CNV gain 25118596
esv4426 CNV loss 18987735
nsv1072406 CNV deletion 25765185
nsv1120122 OTHER inversion 24896259
nsv1123309 CNV deletion 24896259
nsv1127719 CNV deletion 24896259
nsv433177 CNV loss 18776910
nsv435723 CNV deletion 17901297
nsv516338 CNV loss 19592680
nsv517737 CNV loss 19592680
nsv581310 CNV loss 21841781
nsv819369 CNV gain 19587683
nsv820684 CNV deletion 20802225
nsv828775 CNV loss 20364138
nsv955027 CNV deletion 24416366

Variation tolerance for RASGRP3 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASGRP3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASGRP3 Gene

Disorders for RASGRP3 Gene

Additional Disease Information for RASGRP3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RASGRP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASGRP3 Gene

Publications for RASGRP3 Gene

  1. Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. (PMID: 10934204) Rebhun JF … Quilliam LA (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population. (PMID: 20516000) He CF … Yang S (Lupus 2010) 3 44 58
  5. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PMID: 19838193) Han JW … Zhang XJ (Nature genetics 2009) 3 44 58

Products for RASGRP3 Gene

Sources for RASGRP3 Gene