Aliases for DSTYK Gene
External Ids for DSTYK Gene
Previous HGNC Symbols for DSTYK Gene
Previous GeneCards Identifiers for DSTYK Gene
This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
GeneCards Summary for DSTYK Gene
DSTYK (Dual Serine/Threonine And Tyrosine Protein Kinase) is a Protein Coding gene. Diseases associated with DSTYK include Spastic Paraplegia 23, Autosomal Recessive and Congenital Anomalies Of Kidney And Urinary Tract 1. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is WNK1.
UniProtKB/Swiss-Prot Summary for DSTYK Gene
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540).