Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SHC2 Gene

Aliases for SHC2 Gene

  • SHC Adaptor Protein 2 2 3 5
  • SHC (Src Homology 2 Domain Containing) Transforming Protein 2 2 3
  • Src Homology 2 Domain-Containing-Transforming Protein C2 3 4
  • Neuronal Shc Adaptor Homolog 2 3
  • SHC-Transforming Protein B 3 4
  • SH2 Domain Protein C2 3 4
  • Protein Sck 3 4
  • SHCB 3 4
  • SCK 3 4
  • SHC-Transforming Protein 2 3
  • SLI 3

External Ids for SHC2 Gene

Previous GeneCards Identifiers for SHC2 Gene

  • GC19U900043
  • GC19M000369
  • GC19M000186

Summaries for SHC2 Gene

GeneCards Summary for SHC2 Gene

SHC2 (SHC Adaptor Protein 2) is a Protein Coding gene. Among its related pathways are Endometrial cancer and RET signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and receptor tyrosine kinase binding. An important paralog of this gene is SHC1.

UniProtKB/Swiss-Prot for SHC2 Gene

  • Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).

Gene Wiki entry for SHC2 Gene

Additional gene information for SHC2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHC2 Gene

Genomics for SHC2 Gene

GeneHancer (GH) Regulatory Elements for SHC2 Gene

Promoters and enhancers for SHC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J000459 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 679.9 -0.1 -69 3.3 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF213 ZNF263 SP3 SP5 REST SHC2 TMEM259 RNA5SP462 CIRBP C19orf24 GRIN3B MED16 MIER2 ODF3L2
GH19J000487 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -27.8 -27820 2.7 HDGF SMAD1 ARNT ARID4B SIN3A POLR2B ZNF766 ZNF207 ZNF143 SP3 MADCAM1 DAZAP1 TMEM259 SHC2 LOC105372232 MIER2 PTBP1 MED16 ENSG00000267317 RNF126
GH19J000493 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 13.2 -33.8 -33805 3.6 ATF1 ARID4B ZNF48 ZNF280A GTF3C2 GLIS2 ZNF143 KLF7 ATF7 ZNF202 MADCAM1 TMEM259 DAZAP1 PTBP1 MED16 ENSG00000267317 CIRBP GRIN3B LOC105372232 SHC2
GH19J000485 Enhancer 1.3 FANTOM5 Ensembl ENCODE 15.3 -24.8 -24836 1.3 DRAP1 ELF3 SOX13 TFAP4 MXI1 ZBTB6 ZNF792 SAP130 MLX ARID4B SHC2 FGF22 HCN2 MADCAM1 PALM C2CD4C ODF3L2
GH19J001130 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.9 -671.5 -671510 4.3 HDGF HDAC1 PKNOX1 RB1 SIN3A STAT5A ZBTB40 KLF5 ZNF121 EGR1 SBNO2 MIDN ARHGAP45 POLR2E SHC2 R3HDM4 ABCA7 ARID3A CIRBP TMEM259
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SHC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SHC2 gene promoter:
  • E2F
  • E2F-1
  • STAT5A
  • COMP1
  • ATF6
  • p53
  • Pax-4a
  • SRF (504 AA)
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for SHC2 Gene

Genomic Locations for SHC2 Gene
44,442 bases
Minus strand
44,414 bases
Minus strand

Genomic View for SHC2 Gene

Genes around SHC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHC2 Gene

Proteins for SHC2 Gene

  • Protein details for SHC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SHC-transforming protein 2
    Protein Accession:
    Secondary Accessions:
    • O60230
    • Q9NPL5
    • Q9UCX4

    Protein attributes for SHC2 Gene

    582 amino acids
    Molecular mass:
    61916 Da
    Quaternary structure:
    • Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.
    • PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.

neXtProt entry for SHC2 Gene

Post-translational modifications for SHC2 Gene

Other Protein References for SHC2 Gene

No data available for DME Specific Peptides for SHC2 Gene

Domains & Families for SHC2 Gene

Gene Families for SHC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SHC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The PID domain mediates binding to the TrkA receptor.
  • The PID domain mediates binding to the TrkA receptor.
genes like me logo Genes that share domains with SHC2: view

Function for SHC2 Gene

Molecular function for SHC2 Gene

UniProtKB/Swiss-Prot Function:
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).

Phenotypes From GWAS Catalog for SHC2 Gene

Gene Ontology (GO) - Molecular Function for SHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IPI 15513915
GO:0019901 protein kinase binding IBA --
GO:0030971 receptor tyrosine kinase binding IBA,IEA --
genes like me logo Genes that share ontologies with SHC2: view
genes like me logo Genes that share phenotypes with SHC2: view

Animal Models for SHC2 Gene

MGI Knock Outs for SHC2:

Animal Model Products

miRNA for SHC2 Gene

miRTarBase miRNAs that target SHC2

Clone Products

  • Addgene plasmids for SHC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHC2 Gene

Localization for SHC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHC2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with SHC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SHC2 Gene

Pathways & Interactions for SHC2 Gene

SuperPathway Contained pathways
1 RET signaling
2 Gastric cancer
3 Glioma
4 ErbB signaling pathway
5 Circadian entrainment
genes like me logo Genes that share pathways with SHC2: view

SIGNOR curated interactions for SHC2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007265 Ras protein signal transduction TAS --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with SHC2: view

Drugs & Compounds for SHC2 Gene

(1) Drugs for SHC2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SHC2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SHC2: view

Transcripts for SHC2 Gene

Unigene Clusters for SHC2 Gene

SHC (Src homology 2 domain containing) transforming protein 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for SHC2

Alternative Splicing Database (ASD) splice patterns (SP) for SHC2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -
SP6: -
SP7: -

Relevant External Links for SHC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SHC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHC2 Gene

This gene is overexpressed in Pancreas (x5.9).

Protein differential expression in normal tissues from HIPED for SHC2 Gene

This gene is overexpressed in Monocytes (54.8) and Fetal ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SHC2 Gene

Protein tissue co-expression partners for SHC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SHC2 Gene:


SOURCE GeneReport for Unigene cluster for SHC2 Gene:


mRNA Expression by UniProt/SwissProt for SHC2 Gene:

Tissue specificity: Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.

Evidence on tissue expression from TISSUES for SHC2 Gene

  • Nervous system(4.5)
  • Blood(4.4)
  • Muscle(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with SHC2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SHC2 Gene

Orthologs for SHC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SHC2 34
  • 96 (a)
(Canis familiaris)
Mammalia LOC611955 33
  • 87.74 (n)
(Bos Taurus)
Mammalia LOC533455 33
  • 87.11 (n)
SHC2 34
  • 82 (a)
(Rattus norvegicus)
Mammalia Shc2 33
  • 83.39 (n)
(Mus musculus)
Mammalia Shc2 16 34 33
  • 82.92 (n)
(Ornithorhynchus anatinus)
Mammalia SHC2 34
  • 73 (a)
(Gallus gallus)
Aves SHC2 34 33
  • 73.39 (n)
(Anolis carolinensis)
Reptilia SHC2 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shc2 33
  • 64.57 (n)
(Danio rerio)
Actinopterygii shc2 34 33
  • 69.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta Shc 34
  • 38 (a)
(Caenorhabditis elegans)
Secernentea shc-1 34
  • 28 (a)
Species where no ortholog for SHC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SHC2 Gene

Gene Tree for SHC2 (if available)
Gene Tree for SHC2 (if available)
Evolutionary constrained regions (ECRs) for SHC2: view image

Paralogs for SHC2 Gene

Paralogs for SHC2 Gene

(3) SIMAP similar genes for SHC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SHC2: view

Variants for SHC2 Gene

Sequence variations from dbSNP and Humsavar for SHC2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000027041 -- 416,157(-) C/A downstream_transcript_variant
rs1000055753 -- 454,214(-) C/T intron_variant
rs1000111412 -- 442,205(-) T/C intron_variant
rs1000142206 -- 461,923(-) C/A upstream_transcript_variant
rs1000232414 -- 457,935(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SHC2 Gene

Variant ID Type Subtype PubMed ID
dgv1013e212 CNV gain 25503493
dgv1670n106 CNV deletion 24896259
dgv1671n106 CNV deletion 24896259
dgv1966e59 CNV duplication 20981092
dgv213e215 CNV deletion 23714750
dgv6153n54 CNV loss 21841781
dgv6155n54 CNV loss 21841781
dgv6159n54 CNV loss 21841781
esv1499855 CNV insertion 17803354
esv1557758 CNV deletion 17803354
esv1627441 CNV deletion 17803354
esv1994729 CNV deletion 18987734
esv2223344 CNV deletion 18987734
esv2276998 CNV deletion 18987734
esv23197 CNV gain 19812545
esv2323487 CNV deletion 18987734
esv2497793 CNV deletion 19546169
esv25497 CNV gain+loss 19812545
esv26032 CNV loss 19812545
esv2659245 CNV deletion 23128226
esv2659523 CNV deletion 23128226
esv2661854 CNV deletion 23128226
esv2663200 CNV deletion 23128226
esv2669304 CNV deletion 23128226
esv2671474 CNV deletion 23128226
esv2672865 CNV deletion 23128226
esv2676066 CNV deletion 23128226
esv28823 CNV loss 19812545
esv3494 CNV loss 18987735
esv3555816 CNV deletion 23714750
esv3643351 CNV loss 21293372
esv4763 CNV loss 18987735
esv5410 CNV loss 18987735
nsv1065558 CNV gain 25217958
nsv1071880 CNV deletion 25765185
nsv1072289 CNV deletion 25765185
nsv1072830 CNV deletion 25765185
nsv1123205 CNV deletion 24896259
nsv1125665 CNV tandem duplication 24896259
nsv1130724 CNV deletion 24896259
nsv1134738 CNV deletion 24896259
nsv1142924 CNV tandem duplication 24896259
nsv1145825 CNV duplication 26484159
nsv138298 CNV deletion 16902084
nsv2384 CNV insertion 18451855
nsv428360 CNV gain 18775914
nsv433453 CNV gain 18776910
nsv470101 CNV loss 18288195
nsv509712 CNV insertion 20534489
nsv514895 CNV gain 21397061
nsv577978 CNV gain 21841781
nsv578091 CNV gain 21841781
nsv578092 CNV loss 21841781
nsv578093 CNV gain 21841781
nsv578094 CNV gain+loss 21841781
nsv578097 CNV loss 21841781
nsv817810 CNV loss 17921354
nsv820768 CNV deletion 20802225
nsv828348 CNV loss 20364138
nsv953938 CNV deletion 24416366

Variation tolerance for SHC2 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHC2 Gene

Disorders for SHC2 Gene

Additional Disease Information for SHC2

No disorders were found for SHC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHC2 Gene

Publications for SHC2 Gene

  1. N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling. (PMID: 9507002) Nakamura T … Mori N (The Journal of biological chemistry 1998) 2 3 4 58
  2. A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. (PMID: 8760305) Pelicci G … Pelicci PG (Oncogene 1996) 3 4 22 58
  3. An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. (PMID: 7527937) Kavanaugh WM … Williams LT (Science (New York, N.Y.) 1994) 2 3 4 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  5. ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. (PMID: 12006576) Liu HY … Meakin SO (The Journal of biological chemistry 2002) 3 4 58

Products for SHC2 Gene

Sources for SHC2 Gene

Loading form....