Aliases for KCTD13 Gene
External Ids for KCTD13 Gene
Previous GeneCards Identifiers for KCTD13 Gene
GeneCards Summary for KCTD13 Gene
KCTD13 (Potassium Channel Tetramerization Domain Containing 13) is a Protein Coding gene. Diseases associated with KCTD13 include Osteoarthritis and Hepatocellular Carcinoma. Among its related pathways are Hepatic ABC Transporters and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein domain specific binding. An important paralog of this gene is KCTD10.
UniProtKB/Swiss-Prot for KCTD13 Gene
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:19782033). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome (PubMed:19782033) Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity).