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Aliases for IFI6 Gene

Aliases for IFI6 Gene

  • Interferon Alpha Inducible Protein 6 2 3 5
  • Interferon-Induced Protein 6-16 3 4
  • G1P3 3 4
  • Interferon, Alpha-Inducible Protein (Clone IFI-6-16) 2
  • Interferon, Alpha-Inducible Protein Clone IFI-6-16 3
  • Interferon Alpha-Inducible Protein 6 3
  • IFI-6-16 3
  • Ifi-6-16 4
  • FAM14C 3
  • IFI616 3
  • 6-16 3

External Ids for IFI6 Gene

Previous HGNC Symbols for IFI6 Gene

  • G1P3

Previous GeneCards Identifiers for IFI6 Gene

  • GC01M027865
  • GC01M027992
  • GC01M026248

Summaries for IFI6 Gene

Entrez Gene Summary for IFI6 Gene

  • This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for IFI6 Gene

IFI6 (Interferon Alpha Inducible Protein 6) is a Protein Coding gene. Among its related pathways are Type II interferon signaling (IFNG) and Innate Lymphoid Cell Differentiation Pathways. An important paralog of this gene is IFI27L2.

Gene Wiki entry for IFI6 Gene

Additional gene information for IFI6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI6 Gene

Genomics for IFI6 Gene

GeneHancer (GH) Regulatory Elements for IFI6 Gene

Promoters and enhancers for IFI6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J027671 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.1 -87 2.6 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF548 IFI6 ARID1A TRNAU1AP GMEB1 SNHG12 MAP3K6 ACTG1P20 FAM76A ENSG00000231344 EYA3
GH01J027668 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 0.7 +2.9 2924 1.1 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A YBX1 ZNF2 YY1 TCF12 ENSG00000225886 GC01P027670 EYA3 GMEB1 PTAFR GPATCH3 ARID1A IFI6 LINC02574
GH01J027667 Enhancer 0.8 ENCODE dbSUPER 0.7 +4.5 4473 0.2 SMARCE1 YBX3 CBFA2T3 DPF2 FOSL1 JUND HMBOX1 KDM1A CUX1 ENSG00000225886 GC01P027670 IFI6 LINC02574
GH01J027666 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 +5.2 5242 0.5 HDGF HDAC1 ATF1 RB1 NFRKB KLF17 NFXL1 EGR1 ATF7 CREM GC01P027670 LINC02574 IFI6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFI6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFI6 gene promoter:
  • IRF-1
  • Ik-2
  • STAT3
  • HNF-4alpha1
  • PPAR-gamma2

Genomic Locations for IFI6 Gene

Genomic Locations for IFI6 Gene
6,158 bases
Minus strand
6,158 bases
Minus strand

Genomic View for IFI6 Gene

Genes around IFI6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI6 Gene

Proteins for IFI6 Gene

  • Protein details for IFI6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-inducible protein 6
    Protein Accession:
    Secondary Accessions:
    • Q13141
    • Q13142
    • Q5VVR2
    • Q5VVR3
    • Q6IE95
    • Q969M8

    Protein attributes for IFI6 Gene

    130 amino acids
    Molecular mass:
    12927 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IFI6 Gene


neXtProt entry for IFI6 Gene

Post-translational modifications for IFI6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFI6 Gene

No data available for DME Specific Peptides for IFI6 Gene

Domains & Families for IFI6 Gene

Gene Families for IFI6 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for IFI6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IFI6/IFI27 family.
  • Belongs to the IFI6/IFI27 family.
genes like me logo Genes that share domains with IFI6: view

Function for IFI6 Gene

Molecular function for IFI6 Gene

UniProtKB/Swiss-Prot Induction:
By alpha and beta interferons.

Gene Ontology (GO) - Molecular Function for IFI6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15685448
genes like me logo Genes that share ontologies with IFI6: view
genes like me logo Genes that share phenotypes with IFI6: view

Animal Model Products

miRNA for IFI6 Gene

miRTarBase miRNAs that target IFI6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFI6 Gene

Localization for IFI6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFI6 gene
Compartment Confidence
mitochondrion 5
plasma membrane 4
extracellular 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IFI6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 15685448
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFI6: view

Pathways & Interactions for IFI6 Gene

genes like me logo Genes that share pathways with IFI6: view

Pathways by source for IFI6 Gene

1 GeneGo (Thomson Reuters) pathway for IFI6 Gene
1 R&D Systems pathway for IFI6 Gene

Gene Ontology (GO) - Biological Process for IFI6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001836 release of cytochrome c from mitochondria IMP 15685448
GO:0006955 immune response TAS 3017706
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP 15685448
GO:0051902 negative regulation of mitochondrial depolarization IMP 15685448
GO:0060337 type I interferon signaling pathway TAS --
genes like me logo Genes that share ontologies with IFI6: view

No data available for SIGNOR curated interactions for IFI6 Gene

Drugs & Compounds for IFI6 Gene

No Compound Related Data Available

Transcripts for IFI6 Gene

mRNA/cDNA for IFI6 Gene

Unigene Clusters for IFI6 Gene

Interferon, alpha-inducible protein 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFI6 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -

Relevant External Links for IFI6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFI6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFI6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFI6 Gene

This gene is overexpressed in Pituitary (x4.4).

Protein differential expression in normal tissues from HIPED for IFI6 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IFI6 Gene

Protein tissue co-expression partners for IFI6 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFI6 Gene:


SOURCE GeneReport for Unigene cluster for IFI6 Gene:


Evidence on tissue expression from TISSUES for IFI6 Gene

  • Nervous system(4.5)
  • Skin(4.2)
  • Liver(2.6)
  • Heart(2.1)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with IFI6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFI6 Gene

Orthologs for IFI6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFI6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFI6 34 33
  • 99.23 (n)
(Canis familiaris)
Mammalia IFI6 34 33
  • 78.2 (n)
(Bos Taurus)
Mammalia IFI6 34 33
  • 72.09 (n)
(Monodelphis domestica)
Mammalia IFI6 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia IFI6 34
  • 39 (a)
Species where no ortholog for IFI6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFI6 Gene

Gene Tree for IFI6 (if available)
Gene Tree for IFI6 (if available)
Evolutionary constrained regions (ECRs) for IFI6: view image

Paralogs for IFI6 Gene

Paralogs for IFI6 Gene

(3) SIMAP similar genes for IFI6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFI6: view

Variants for IFI6 Gene

Sequence variations from dbSNP and Humsavar for IFI6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000846998 -- 27,672,023(-) A/G intron_variant
rs1001014579 -- 27,665,658(-) C/T downstream_transcript_variant
rs1001231343 -- 27,670,088(-) G/A intron_variant
rs1001473231 -- 27,672,387(-) G/C upstream_transcript_variant
rs1001577474 -- 27,670,301(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IFI6 Gene

Variant ID Type Subtype PubMed ID
esv2745763 CNV deletion 23290073
esv2745774 CNV deletion 23290073
esv2745785 CNV deletion 23290073
nsv522842 CNV gain 19592680

Variation tolerance for IFI6 Gene

Gene Damage Index Score: 0.01; 0.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFI6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI6 Gene

Disorders for IFI6 Gene

Additional Disease Information for IFI6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IFI6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFI6 Gene

Publications for IFI6 Gene

  1. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58
  2. G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells. (PMID: 17823654) Cheriyath V … Borden EC (The Journal of clinical investigation 2007) 3 22 58
  3. G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell. (PMID: 15685448) Tahara E … Tahara E (Cancer immunology, immunotherapy : CII 2005) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12. (PMID: 14728724) Parker N … Porter AC (BMC genomics 2004) 3 4 58

Products for IFI6 Gene

Sources for IFI6 Gene

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