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Aliases for ALPG Gene

Aliases for ALPG Gene

  • Alkaline Phosphatase, Germ Cell 2 3
  • Alkaline Phosphatase, Placental Like 2 2 3 5
  • Germ Cell Alkaline Phosphatase 2 3 4
  • Alkaline Phosphatase Nagao Isozyme 3 4
  • ALPPL2 3 5
  • ALP-1 3 4
  • ALPPL 3 4
  • GCAP 3 4
  • Testicular And Thymus Alkaline Phosphatase 3
  • Alkaline Phosphatase, Placental-Like 3
  • Placental-Like Alkaline Phosphatase 3
  • Placental Alkaline Phosphatase-Like 4
  • Nagao Isozyme 3
  • EC 4
  • PLAP-Like 4

External Ids for ALPG Gene

Previous HGNC Symbols for ALPG Gene

  • ALPPL2

Summaries for ALPG Gene

Entrez Gene Summary for ALPG Gene

  • There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALPG Gene

ALPG (Alkaline Phosphatase, Germ Cell) is a Protein Coding gene. Diseases associated with ALPG include Seminoma and Gonadoblastoma. Among its related pathways are Folate biosynthesis and Metabolism of proteins. An important paralog of this gene is ALPP.

Additional gene information for ALPG Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALPG Gene

Genomics for ALPG Gene

GeneHancer (GH) Regulatory Elements for ALPG Gene

Promoters and enhancers for ALPG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J232406 Promoter 0.6 EPDnew 650.7 0.0 -17 0.1 KLF1 ALPG ECEL1P2
GH02J232418 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +13.3 13278 3.6 ELF3 CTCF ZBTB6 SIN3A ZNF335 CTBP1 POLR2A SCRT2 ZNF143 ZNF444 ECEL1P1 ENSG00000237087 ECEL1P2 ALPG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ALPG on UCSC Golden Path with GeneCards custom track

Genomic Locations for ALPG Gene

Genomic Locations for ALPG Gene
3,873 bases
Plus strand
3,873 bases
Plus strand

Genomic View for ALPG Gene

Genes around ALPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPG Gene

Proteins for ALPG Gene

  • Protein details for ALPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alkaline phosphatase, placental-like
    Protein Accession:
    Secondary Accessions:
    • A8KAF2
    • Q16727
    • Q53S81
    • Q96CM1

    Protein attributes for ALPG Gene

    532 amino acids
    Molecular mass:
    57377 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    • In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).
    • Sequence=CAA30232.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ALPG Gene

Post-translational modifications for ALPG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALPG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ALPG Gene

Domains & Families for ALPG Gene

Gene Families for ALPG Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ALPG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alkaline phosphatase family.
  • Belongs to the alkaline phosphatase family.
genes like me logo Genes that share domains with ALPG: view

Function for ALPG Gene

Molecular function for ALPG Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate.

Enzyme Numbers (IUBMB) for ALPG Gene

Gene Ontology (GO) - Molecular Function for ALPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004035 alkaline phosphatase activity NAS 2162249
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ALPG: view
genes like me logo Genes that share phenotypes with ALPG: view

Animal Models for ALPG Gene

MGI Knock Outs for ALPG:

Animal Model Products

CRISPR Products

miRNA for ALPG Gene

miRTarBase miRNAs that target ALPG

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALPG

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALPG Gene

Localization for ALPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALPG Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALPG gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ALPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with ALPG: view

Pathways & Interactions for ALPG Gene

genes like me logo Genes that share pathways with ALPG: view

Pathways by source for ALPG Gene

Gene Ontology (GO) - Biological Process for ALPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0008152 metabolic process IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with ALPG: view

No data available for SIGNOR curated interactions for ALPG Gene

Drugs & Compounds for ALPG Gene

(19) Drugs for ALPG Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amifostine Approved, Investigational Pharma Target, inducer 81
Levamisole Approved, Investigational, Vet_approved, Withdrawn Pharma Target, inhibitor 16
Hydrogen peroxide Approved, Vet_approved Pharma Enzyme, inhibitor 73
Strontium chloride Sr-89 Approved, Investigational Pharma Enzyme, cofactor 0
Zinc sulfate Approved, Investigational Pharma Enzyme, cofactor 75

(10) Additional Compounds for ALPG Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Caproic alcohol
  • Hexanol
  • N-Hexyl alcohol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Amyl alcohol, normal
  • Amylalkohol
dihydroneopterin triphosphate
  • 2-amino-4-Hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
  • 6-(L-erythro-1,2-Dihydroxy-3-triphosphooxypropyl)-7,8-dihydropterin
  • 6-(L-erythro-1,2-Dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
  • 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin
  • 2-amino-4-Hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphoric acid
  • 1-Hydroxymethylpropane
  • 2-Methyl-1-propanol
  • 2-Methylpropanol
  • I-butanol
  • I-butyl alcohol
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
genes like me logo Genes that share compounds with ALPG: view

Transcripts for ALPG Gene

mRNA/cDNA for ALPG Gene

(1) REFSEQ mRNAs :
(152) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALPG

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALPG Gene

No ASD Table

Relevant External Links for ALPG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ALPG Gene:


mRNA Expression by UniProt/SwissProt for ALPG Gene:

Tissue specificity: Trace amounts in the testis and thymus, and in elevated amounts in germ cell tumors.

Evidence on tissue expression from TISSUES for ALPG Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ALPG: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALPG Gene

Orthologs for ALPG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALPG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ALPPL2 34 33
  • 99.06 (n)
(Mus musculus)
Mammalia Alppl2 16 34 33
  • 78.19 (n)
Alpi 34
  • 70 (a)
Akp3 34
  • 69 (a)
(Rattus norvegicus)
Mammalia Alpp 33
  • 77.51 (n)
(Bos Taurus)
Mammalia -- 34
  • 77 (a)
-- 34
  • 76 (a)
-- 34
  • 73 (a)
-- 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
(Canis familiaris)
Mammalia -- 34
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 70 (a)
(Gallus gallus)
Aves -- 34
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 60 (a)
(Danio rerio)
Actinopterygii alpi.2 34
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3290 34 33
  • 52.65 (n)
CG5656 34
  • 37 (a)
CG1809 34
  • 37 (a)
CG5150 34
  • 36 (a)
CG10827 34
  • 35 (a)
CG8105 34
  • 35 (a)
CG3264 34
  • 34 (a)
CG8147 34
  • 34 (a)
CG10592 34
  • 34 (a)
CG3292 34
  • 33 (a)
Aph-4 34
  • 32 (a)
CG16771 34
  • 27 (a)
CG5361 34
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO8 36 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
-- 34
  • 39 (a)
CSA.180 34
  • 38 (a)
-- 34
  • 38 (a)
CSA.4362 34
  • 37 (a)
Species where no ortholog for ALPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALPG Gene

Gene Tree for ALPG (if available)
Gene Tree for ALPG (if available)
Evolutionary constrained regions (ECRs) for ALPG: view image

Paralogs for ALPG Gene

Paralogs for ALPG Gene

genes like me logo Genes that share paralogs with ALPG: view

Variants for ALPG Gene

Sequence variations from dbSNP and Humsavar for ALPG Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1001565605 -- 232,409,079(+) G/A coding_sequence_variant, missense_variant
rs1002575086 -- 232,410,421(+) C/G 3_prime_UTR_variant
rs1002723586 -- 232,405,481(+) G/A upstream_transcript_variant
rs1003794478 -- 232,406,650(+) G/T upstream_transcript_variant
rs1003854496 -- 232,411,109(+) T/C/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ALPG Gene

Variant ID Type Subtype PubMed ID
dgv1218e212 CNV loss 25503493
dgv160n111 CNV duplication 26073780
dgv4182n100 CNV gain 25217958
dgv4183n100 CNV gain+loss 25217958
dgv4184n100 CNV loss 25217958
dgv4185n100 CNV gain 25217958
dgv4186n100 CNV loss 25217958
dgv4187n100 CNV loss 25217958
dgv493n27 CNV loss 19166990
dgv494n27 CNV gain 19166990
dgv632e201 CNV deletion 23290073
dgv7336n54 CNV gain 21841781
dgv7337n54 CNV loss 21841781
dgv7338n54 CNV gain 21841781
dgv765e214 CNV loss 21293372
esv2659833 CNV deletion 23128226
esv2759118 CNV gain 17122850
esv2760660 CNV loss 21179565
esv2763626 CNV gain+loss 21179565
esv34493 CNV gain 17911159
esv3561154 CNV deletion 23714750
esv3575339 CNV gain 25503493
esv3575340 CNV gain 25503493
esv3594646 CNV loss 21293372
esv3594649 CNV gain 21293372
esv3594651 CNV loss 21293372
esv3594652 CNV gain 21293372
esv3893570 CNV gain+loss 25118596
esv3893572 CNV loss 25118596
nsv1003690 CNV gain+loss 25217958
nsv1009043 CNV gain 25217958
nsv436293 CNV deletion 17901297
nsv472038 CNV novel sequence insertion 20440878
nsv482058 CNV gain 20164927
nsv518263 CNV loss 19592680
nsv521461 CNV loss 19592680
nsv522450 CNV loss 19592680
nsv584679 CNV gain 21841781
nsv584687 CNV gain+loss 21841781
nsv584692 CNV loss 21841781
nsv584693 CNV loss 21841781
nsv821918 CNV gain 20364138

Variation tolerance for ALPG Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALPG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALPG Gene

Disorders for ALPG Gene

MalaCards: The human disease database

(5) MalaCards diseases for ALPG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • seminoma, pure
  • gby
  • chorioepithelioma
complete androgen insensitivity syndrome
  • testicular feminization
cryptorchidism, unilateral or bilateral
  • undescended testis
- elite association - COSMIC cancer census association via MalaCards
Search ALPG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ALPG

genes like me logo Genes that share disorders with ALPG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALPG Gene

Publications for ALPG Gene

  1. Molecular cloning of complementary DNAs encoding alkaline phosphatase in human colon cancer cells. (PMID: 2297757) Gum JR … Kim YS (Cancer research 1990) 3 4 22 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Elevated serum alkaline phosphatase may enable early diagnosis of ovarian cancer. (PMID: 10471145) Ben-Arie A … Dgani R (European journal of obstetrics, gynecology, and reproductive biology 1999) 3 22 58
  5. Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning. (PMID: 9823315) Shigenari A … Inoko H (Cancer research 1998) 3 22 58

Products for ALPG Gene

Sources for ALPG Gene

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