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Aliases for PANX1 Gene

Aliases for PANX1 Gene

  • Pannexin 1 2 3 5
  • Innexin 2 3
  • MRS1 3 4
  • Pannexin-1 3
  • UNQ2529 3
  • PX1 3

External Ids for PANX1 Gene

Previous GeneCards Identifiers for PANX1 Gene

  • GC11P096192
  • GC11P095369
  • GC11P094046
  • GC11P093550
  • GC11P093501
  • GC11P093862
  • GC11P089937

Summaries for PANX1 Gene

Entrez Gene Summary for PANX1 Gene

  • The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]

GeneCards Summary for PANX1 Gene

PANX1 (Pannexin 1) is a Protein Coding gene. Diseases associated with PANX1 include Pineal Parenchymal Tumor Of Intermediate Differentiation and Basilar Artery Occlusion. Among its related pathways are Apoptosis and Autophagy and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and actin binding. An important paralog of this gene is PANX3.

UniProtKB/Swiss-Prot for PANX1 Gene

  • Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.

Tocris Summary for PANX1 Gene

  • Gap channels (gap junctions) are specialized cell-cell contacts that provide direct intracellular communication. They allow passive diffusion of molecules up to 1 kDa, including nutrients, metabolites (glucose), ions (K+, Ca2+) and second messengers (IP3, cAMP).

Additional gene information for PANX1 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PANX1 Gene

Genomics for PANX1 Gene

GeneHancer (GH) Regulatory Elements for PANX1 Gene

Promoters and enhancers for PANX1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J094127 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 674 +3.6 3557 10.4 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF207 ZNF143 FOS PANX1 MED17 ANKRD49 MRE11 SNORA1 HEPHL1 CEP295 ENSG00000255445 FUT4 PIR47114
GH11J094148 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.7 +22.6 22644 5.6 PKNOX1 ATF1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 YY1 ATF7 FOS HEPHL1 PANX1 PIR47114 GC11P094183
GH11J094237 Enhancer 0.8 ENCODE 10.1 +108.9 108902 0.1 ZNF473 ZNF195 KLF14 BRCA1 YY1 GLIS2 HSF1 ZNF416 ZNF350 MCM3 CEP295 MED17 MRE11 ANKRD49 SNORA1 BUD13P1 ENSG00000270578 ENSG00000233536 LOC100420801 KDM4F
GH11J094567 Promoter 1.1 EPDnew 7.1 +438.4 438421 0.1 HDAC1 ATF1 TAF9B NFRKB ZNF766 EGR1 ATF7 SMAD5 ZBTB2 ZBTB11 PIWIL4 PANX1 GC11M094556 LOC105369436 LOC105369438
GH11J094171 Enhancer 0.6 ENCODE 12.7 +43.4 43424 1.2 CTCF ZNF654 TRIM22 REST ZNF384 RAD21 GLIS2 KLF16 ZNF143 SMC3 HEPHL1 PANX1 GC11P094183 PIR47114
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PANX1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PANX1 gene promoter:
  • IRF-1
  • RP58
  • STAT5A
  • Tal-1
  • E47
  • POU6F1 (c2)
  • Tal-1beta
  • ITF-2
  • AML1a
  • HNF-3beta

Genomic Locations for PANX1 Gene

Genomic Locations for PANX1 Gene
56,669 bases
Plus strand
53,045 bases
Plus strand

Genomic View for PANX1 Gene

Genes around PANX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PANX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PANX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PANX1 Gene

Proteins for PANX1 Gene

  • Protein details for PANX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O75968
    • Q543A0
    • Q6UW26
    • Q96AM9
    • Q96L77
    • Q96RS5

    Protein attributes for PANX1 Gene

    426 amino acids
    Molecular mass:
    48050 Da
    Quaternary structure:
    • Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes (By similarity).

    Alternative splice isoforms for PANX1 Gene


neXtProt entry for PANX1 Gene

Post-translational modifications for PANX1 Gene

Other Protein References for PANX1 Gene

Antibody Products

No data available for DME Specific Peptides for PANX1 Gene

Domains & Families for PANX1 Gene

Gene Families for PANX1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for PANX1 Gene


Suggested Antigen Peptide Sequences for PANX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pannexin family.
  • Belongs to the pannexin family.
genes like me logo Genes that share domains with PANX1: view

Function for PANX1 Gene

Molecular function for PANX1 Gene

UniProtKB/Swiss-Prot Function:
Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.

Phenotypes From GWAS Catalog for PANX1 Gene

Gene Ontology (GO) - Molecular Function for PANX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005102 signaling receptor binding IPI 17036048
GO:0005243 gap junction channel activity IEA --
GO:0005262 calcium channel activity IMP 16908669
GO:0015267 channel activity IEA --
genes like me logo Genes that share ontologies with PANX1: view
genes like me logo Genes that share phenotypes with PANX1: view

Animal Models for PANX1 Gene

MGI Knock Outs for PANX1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PANX1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PANX1 Gene

Localization for PANX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PANX1 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PANX1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
extracellular 2
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PANX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA,IEA 16908669
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0005921 gap junction IEA --
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with PANX1: view

Pathways & Interactions for PANX1 Gene

genes like me logo Genes that share pathways with PANX1: view

Pathways by source for PANX1 Gene

1 R&D Systems pathway for PANX1 Gene
2 Cell Signaling Technology pathways for PANX1 Gene

Gene Ontology (GO) - Biological Process for PANX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IDA 17036048
GO:0006816 calcium ion transport IMP 16908669
GO:0007267 cell-cell signaling IBA --
genes like me logo Genes that share ontologies with PANX1: view

No data available for SIGNOR curated interactions for PANX1 Gene

Drugs & Compounds for PANX1 Gene

(11) Drugs for PANX1 Gene - From: DrugBank, ClinicalTrials, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Probenecid Approved, Investigational Pharma Inhibition, Inhibitor, Activator, Target, antagonist 35
Carbenoxolone Experimental Pharma Inhibitor 0
Flufenamic Acid Experimental Pharma Channel blocker, Inhibitor, Pore Blocker, Antagonist Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6 1
10Panx Pharma Panx-1 mimetic inhibitor, Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions 0
Scrambled 10Panx Pharma Panx-1 mimetic inhibitory peptide, blocks pannexin-1 gap junctions, Scrambled version of 10Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide 0

(5) Tocris Compounds for PANX1 Gene

Compound Action Cas Number
10Panx Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions 955091-53-9
Carbenoxolone disodium Gap junction blocker. Also inhibitor of 11 beta-hydroxysteroid dehydrogenase 7421-40-1
Gap 26 Gap junction blocker; inhibits smooth muscle contraction and IP3-mediated ATP release 197250-15-0
Gap 27 Selective gap junction blocker 198284-64-9
Scrambled 10Panx Scrambled version of 10Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide 1315378-72-3
genes like me logo Genes that share compounds with PANX1: view

Transcripts for PANX1 Gene

mRNA/cDNA for PANX1 Gene

Unigene Clusters for PANX1 Gene

Pannexin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PANX1

Alternative Splicing Database (ASD) splice patterns (SP) for PANX1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP2: -

Relevant External Links for PANX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PANX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PANX1 Gene

Protein differential expression in normal tissues from HIPED for PANX1 Gene

This gene is overexpressed in Pancreas (18.0), Plasma (17.6), Peripheral blood mononuclear cells (10.5), Bone marrow mesenchymal stem cell (8.9), and Fetal Brain (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PANX1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PANX1 Gene:


SOURCE GeneReport for Unigene cluster for PANX1 Gene:


Evidence on tissue expression from TISSUES for PANX1 Gene

  • Bone(4.1)
  • Nervous system(3.4)
  • Muscle(2.5)
  • Heart(2.2)
  • Lung(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with PANX1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PANX1 Gene

Orthologs for PANX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PANX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PANX1 34 33
  • 99.37 (n)
(Canis familiaris)
Mammalia PANX1 34 33
  • 85.14 (n)
(Bos Taurus)
Mammalia PANX1 34 33
  • 83.85 (n)
(Mus musculus)
Mammalia Panx1 16 34 33
  • 83.84 (n)
(Rattus norvegicus)
Mammalia Panx1 33
  • 82.51 (n)
(Monodelphis domestica)
Mammalia PANX1 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia PANX1 34
  • 76 (a)
(Gallus gallus)
Aves PANX1 34
  • 67 (a)
(Anolis carolinensis)
Reptilia PANX1 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia panx1 33
  • 66.82 (n)
Str.14956 33
(Danio rerio)
Actinopterygii panx1a 34 33
  • 59.47 (n)
panx1b 34
  • 56 (a)
zgc55631 33
Species where no ortholog for PANX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PANX1 Gene

Gene Tree for PANX1 (if available)
Gene Tree for PANX1 (if available)
Evolutionary constrained regions (ECRs) for PANX1: view image

Paralogs for PANX1 Gene

Paralogs for PANX1 Gene

(1) SIMAP similar genes for PANX1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PANX1: view

Variants for PANX1 Gene

Sequence variations from dbSNP and Humsavar for PANX1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs143240087 uncertain-significance, not provided 94,179,706(+) G/A/T coding_sequence_variant, missense_variant
rs1000016498 -- 94,167,621(+) T/G intron_variant
rs1000085824 -- 94,153,370(+) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000274772 -- 94,186,093(+) G/A downstream_transcript_variant
rs1000289672 -- 94,165,951(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PANX1 Gene

Variant ID Type Subtype PubMed ID
esv2656589 CNV deletion 23128226
esv2674143 CNV deletion 23128226
esv2744929 CNV deletion 23290073
esv3548180 CNV deletion 23714750
esv3579855 CNV loss 25503493
esv3627310 CNV gain 21293372
esv3627311 CNV loss 21293372
esv3627312 CNV gain 21293372
esv3627313 CNV gain 21293372
esv3627314 CNV loss 21293372
esv3892071 CNV loss 25118596
esv989619 CNV deletion 20482838
nsv1046092 CNV loss 25217958
nsv468795 CNV loss 19166990
nsv469980 CNV loss 18288195
nsv508651 CNV deletion 20534489
nsv517664 CNV loss 19592680
nsv523082 CNV gain 19592680
nsv555966 CNV loss 21841781

Variation tolerance for PANX1 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.55; 72.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PANX1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PANX1 Gene

Disorders for PANX1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PANX1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pineal parenchymal tumor of intermediate differentiation
  • pineal parenchymal tumour of intermediate differentiation
basilar artery occlusion
  • acute coronary syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PANX1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PANX1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PANX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PANX1 Gene

Publications for PANX1 Gene

  1. Functional implications of calcium permeability of the channel formed by pannexin 1. (PMID: 16908669) Vanden Abeele F … Prevarskaya N (The Journal of cell biology 2006) 3 4 22 58
  2. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. (PMID: 15028292) Baranova A … Panchin Y (Genomics 2004) 3 4 22 58
  3. Pannexins, a family of gap junction proteins expressed in brain. (PMID: 14597722) Bruzzone R … Monyer H (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 22 58
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58
  5. Lack of coupling between membrane stretching and pannexin-1 hemichannels. (PMID: 19150332) Reyes JP … Arreola J (Biochemical and biophysical research communications 2009) 3 22 58

Products for PANX1 Gene

Sources for PANX1 Gene

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