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Aliases for NAA80 Gene

Aliases for NAA80 Gene

  • N(Alpha)-Acetyltransferase 80, NatH Catalytic Subunit 2 3
  • N-Acetyltransferase 6 2 3 5
  • Protein Fusion-2 3 4
  • NAT6 3 5
  • FUS2 3 4
  • N-Acetyltransferase 6 (GCN5-Related) 3
  • Protein Fus-2 4
  • EC 2.3.1.- 4
  • FUS-2 3

External Ids for NAA80 Gene

Previous HGNC Symbols for NAA80 Gene

  • NAT6

Summaries for NAA80 Gene

Entrez Gene Summary for NAA80 Gene

  • This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

GeneCards Summary for NAA80 Gene

NAA80 (N(Alpha)-Acetyltransferase 80, NatH Catalytic Subunit) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NAA80 Gene

  • Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor.

Additional gene information for NAA80 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA80 Gene

Genomics for NAA80 Gene

GeneHancer (GH) Regulatory Elements for NAA80 Gene

Promoters and enhancers for NAA80 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J050297 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 656.2 -1.5 -1494 6.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 HYAL3 HYAL1 NAA80 SEMA3F-AS1 RBM5 TMEM115 CYB561D2 AMT DAG1 RNF123
GH03J050327 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 23.2 -28.6 -28616 2 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 IRF4 ZNF48 YY1 TUSC2 NAA80 HYAL3 HYAL1 MST1 HYAL2
GH03J050234 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13 +54.2 54165 21.2 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF207 GNAI2 RBM5 RBM6 SEMA3F-AS1 HYAL3 TMEM115 HYAL1 CYB561D2 RHOA-IT1 AMT
GH03J050598 Promoter/Enhancer 3.2 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 -307.1 -307066 15 CLOCK MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC CISH MAPKAPK3 RBM5 RBM6 TMEM115 HEMK1 RAD54L2 SEMA3F-AS1 C3orf18 DCAF1
GH03J049467 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.4 +829.5 829497 5.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A YY1 ZNF213 ZNF207 ZNF143 DAG1 AMT ENSG00000235236 WDR6 RBM5 RBM6 QRICH1 IP6K2 LAMB2 NAA80
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAA80 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NAA80 Gene

Genomic Locations for NAA80 Gene
chr3:50,296,402-50,299,421
(GRCh38/hg38)
Size:
3,020 bases
Orientation:
Minus strand
chr3:50,333,833-50,336,852
(GRCh37/hg19)
Size:
3,020 bases
Orientation:
Minus strand

Genomic View for NAA80 Gene

Genes around NAA80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA80 Gene

Proteins for NAA80 Gene

  • Protein details for NAA80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93015-NAT6_HUMAN
    Recommended name:
    N-acetyltransferase 6
    Protein Accession:
    Q93015
    Secondary Accessions:
    • Q93014

    Protein attributes for NAA80 Gene

    Size:
    286 amino acids
    Molecular mass:
    31445 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAA80 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA80 Gene

Post-translational modifications for NAA80 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAA80 Gene

Domains & Families for NAA80 Gene

Gene Families for NAA80 Gene

Protein Domains for NAA80 Gene

Suggested Antigen Peptide Sequences for NAA80 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q93015

UniProtKB/Swiss-Prot:

NAT6_HUMAN :
  • Belongs to the acetyltransferase family.
Family:
  • Belongs to the acetyltransferase family.
genes like me logo Genes that share domains with NAA80: view

Function for NAA80 Gene

Molecular function for NAA80 Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor.

Enzyme Numbers (IUBMB) for NAA80 Gene

Gene Ontology (GO) - Molecular Function for NAA80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008080 N-acetyltransferase activity IDA 10644992
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:1905502 acetyl-CoA binding IDA 10644992
genes like me logo Genes that share ontologies with NAA80: view
genes like me logo Genes that share phenotypes with NAA80: view

Animal Model Products

miRNA for NAA80 Gene

miRTarBase miRNAs that target NAA80

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA80 Gene

Localization for NAA80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA80 Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for NAA80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10644992
genes like me logo Genes that share ontologies with NAA80: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for NAA80 Gene

Pathways & Interactions for NAA80 Gene

SuperPathways for NAA80 Gene

No Data Available

Interacting Proteins for NAA80 Gene

Gene Ontology (GO) - Biological Process for NAA80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006473 protein acetylation IDA 10644992
genes like me logo Genes that share ontologies with NAA80: view

No data available for Pathways by source and SIGNOR curated interactions for NAA80 Gene

Drugs & Compounds for NAA80 Gene

(1) Additional Compounds for NAA80 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Hydroxyphenylacetyl-CoA
  • [(2R,3R,4R,5R)-5-(6-Aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-[2-(4-hydroxyphenyl)acetyl]sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
117411-05-9
genes like me logo Genes that share compounds with NAA80: view

Transcripts for NAA80 Gene

mRNA/cDNA for NAA80 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA80 Gene

No ASD Table

Relevant External Links for NAA80 Gene

GeneLoc Exon Structure for
NAA80
ECgene alternative splicing isoforms for
NAA80

Expression for NAA80 Gene

NURSA nuclear receptor signaling pathways regulating expression of NAA80 Gene:

NAA80

mRNA Expression by UniProt/SwissProt for NAA80 Gene:

Q93015-NAT6_HUMAN
Tissue specificity: Strongly expressed in heart and skeletal muscle, followed by brain and pancreas, with weak expression in kidney, liver, and lung and no expression in placenta.

Evidence on tissue expression from TISSUES for NAA80 Gene

  • Pancreas(4.2)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA80 Gene

Orthologs for NAA80 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAA80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAT6 34 33
  • 99.03 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NAT6 33
  • 86.27 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910872 33
  • 83.22 (n)
mouse
(Mus musculus)
Mammalia Nat6 16 34 33
  • 81.14 (n)
cow
(Bos Taurus)
Mammalia NAT6 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAT6 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAT6 34
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAT6 34
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101886319 33
  • 52.69 (n)
NAT6 34
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8481 34
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C56G2.15 34
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToOne
Species where no ortholog for NAA80 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAA80 Gene

ENSEMBL:
Gene Tree for NAA80 (if available)
TreeFam:
Gene Tree for NAA80 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAA80: view image

Paralogs for NAA80 Gene

No data available for Paralogs for NAA80 Gene

Variants for NAA80 Gene

Sequence variations from dbSNP and Humsavar for NAA80 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs117179004 likely-benign, Deficiency of hyaluronoglucosaminidase 50,300,616(-) G/A upstream_transcript_variant
rs1283 likely-benign, Deficiency of hyaluronoglucosaminidase 50,299,991(-) G/A/C/T upstream_transcript_variant
rs142342237 uncertain-significance, Deficiency of hyaluronoglucosaminidase 50,300,514(-) G/C upstream_transcript_variant
rs150976767 uncertain-significance, Deficiency of hyaluronoglucosaminidase 50,300,024(-) C/T upstream_transcript_variant
rs182987423 uncertain-significance, Deficiency of hyaluronoglucosaminidase 50,300,049(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NAA80 Gene

Variant ID Type Subtype PubMed ID
dgv8316n54 CNV loss 21841781
dgv8317n54 CNV loss 21841781
esv2759148 CNV loss 17122850
nsv3813 CNV deletion 18451855
nsv460531 CNV loss 19166990
nsv470561 CNV loss 18288195
nsv523560 CNV loss 19592680
nsv523662 CNV loss 19592680
nsv590255 CNV loss 21841781
nsv834692 CNV loss 17160897
nsv834693 CNV loss 17160897
nsv954855 CNV deletion 24416366

Variation tolerance for NAA80 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.20; 69.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAA80 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA80

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA80 Gene

Disorders for NAA80 Gene

Additional Disease Information for NAA80

No disorders were found for NAA80 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA80 Gene

Publications for NAA80 Gene

  1. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. (PMID: 11085536) Lerman MI … Minna JD (Cancer research 2000) 2 3 4 58
  2. The putative tumour suppressor Fus-2 is an N-acetyltransferase. (PMID: 10644992) Zegerman P … Kouzarides T (Oncogene 2000) 3 4 22 58
  3. NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. (PMID: 29581253) Drazic A … Arnesen T (Proceedings of the National Academy of Sciences of the United States of America 2018) 2 3 58
  4. Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80. (PMID: 29581307) Goris M … Arnesen T (Proceedings of the National Academy of Sciences of the United States of America 2018) 2 3 58
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 58

Products for NAA80 Gene

Sources for NAA80 Gene

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