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Aliases for APOL2 Gene

Aliases for APOL2 Gene

  • Apolipoprotein L2 2 3 3 5
  • Apolipoprotein L-II 2 3 4
  • Apolipoprotein L, 2 3
  • APOL-II 3
  • ApoL-II 4
  • APOL3 3

External Ids for APOL2 Gene

Previous GeneCards Identifiers for APOL2 Gene

  • GC22M033265
  • GC22M034894
  • GC22M034946
  • GC22M036622
  • GC22M019590

Summaries for APOL2 Gene

Entrez Gene Summary for APOL2 Gene

  • This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOL2 Gene

APOL2 (Apolipoprotein L2) is a Protein Coding gene. Diseases associated with APOL2 include Schizophrenia and Phencyclidine Abuse. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). Gene Ontology (GO) annotations related to this gene include signaling receptor binding and high-density lipoprotein particle binding. An important paralog of this gene is APOL1.

UniProtKB/Swiss-Prot for APOL2 Gene

  • May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

Gene Wiki entry for APOL2 Gene

Additional gene information for APOL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOL2 Gene

Genomics for APOL2 Gene

GeneHancer (GH) Regulatory Elements for APOL2 Gene

Promoters and enhancers for APOL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J036236 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.3 1344 3.7 HDGF FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 APOL2 APOL4 ENSG00000273176
GH22J036449 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.3 -212.9 -212897 7.4 HDGF PKNOX1 SMAD1 FOXA2 MLX ARID4B SIN3A FEZF1 ZNF2 IRF4 CSF2RB APOL3 APOL2 NCF4 FOXRED2 ENSG00000228719 TXN2 APOL1 ENSG00000252225
GH22J036348 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.6 -128.9 -128866 40.9 MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MYH9 MCM5 EIF3D TXN2 ENSG00000252225 FOXRED2 RBFOX2 LOC105377199 APOL3 ENSG00000228719
GH22J036206 Enhancer 0.2 FANTOM5 6.5 +33.5 33462 0.2 APOL4 APOL3 APOL2 APOL1
GH22J036249 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 0.4 -10.9 -10906 2.7 PKNOX1 FOXA2 MLX ARID4B SIN3A ZNF48 ZNF143 ATF7 SP5 MIER2 APOL3 MYH9 APOL1 APOL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around APOL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the APOL2 gene promoter:
  • GR-beta
  • GR
  • GR-alpha
  • RREB-1
  • Bach1

Genomic Locations for APOL2 Gene

Genomic Locations for APOL2 Gene
13,752 bases
Minus strand
13,746 bases
Minus strand

Genomic View for APOL2 Gene

Genes around APOL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOL2 Gene

Proteins for APOL2 Gene

  • Protein details for APOL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Apolipoprotein L2
    Protein Accession:
    Secondary Accessions:
    • B0QYK7
    • O95915
    • Q59GW9
    • Q5TH96
    • Q969T6
    • Q9BT28
    • Q9UGT1
    • Q9UH10

    Protein attributes for APOL2 Gene

    337 amino acids
    Molecular mass:
    37092 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD92227.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for APOL2 Gene

Post-translational modifications for APOL2 Gene

  • Ubiquitination at posLast=326326, posLast=320320, Lys196, Lys193, and Lys83
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for APOL2 Gene

Domains & Families for APOL2 Gene

Gene Families for APOL2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for APOL2 Gene


Suggested Antigen Peptide Sequences for APOL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the apolipoprotein L family.
  • Belongs to the apolipoprotein L family.
genes like me logo Genes that share domains with APOL2: view

Function for APOL2 Gene

Molecular function for APOL2 Gene

UniProtKB/Swiss-Prot Function:
May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
GENATLAS Biochemistry:
apolipoprotein L,2

Phenotypes From GWAS Catalog for APOL2 Gene

Gene Ontology (GO) - Molecular Function for APOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding NAS 11374903
GO:0008035 high-density lipoprotein particle binding NAS 11374903
GO:0008289 lipid binding NAS,IEA 11374903
genes like me logo Genes that share ontologies with APOL2: view
genes like me logo Genes that share phenotypes with APOL2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APOL2 Gene

Localization for APOL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOL2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOL2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 3
extracellular 2
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for APOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005789 endoplasmic reticulum membrane NAS 11374903
GO:0016020 membrane IEA,IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with APOL2: view

Pathways & Interactions for APOL2 Gene

genes like me logo Genes that share pathways with APOL2: view

Pathways by source for APOL2 Gene

Gene Ontology (GO) - Biological Process for APOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process NAS 11374903
GO:0006869 lipid transport NAS,IEA 11374903
GO:0006953 acute-phase response NAS 11374903
GO:0007275 multicellular organism development NAS 11374903
GO:0008203 cholesterol metabolic process NAS 11374903
genes like me logo Genes that share ontologies with APOL2: view

No data available for SIGNOR curated interactions for APOL2 Gene

Drugs & Compounds for APOL2 Gene

No Compound Related Data Available

Transcripts for APOL2 Gene

Unigene Clusters for APOL2 Gene

Apolipoprotein L, 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOL2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: -
SP7: - - -
SP8: - - -
SP9: - -
SP10: -

Relevant External Links for APOL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APOL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APOL2 Gene

Protein differential expression in normal tissues from HIPED for APOL2 Gene

This gene is overexpressed in Nasal epithelium (26.1) and Bone (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOL2 Gene

Protein tissue co-expression partners for APOL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of APOL2 Gene:


SOURCE GeneReport for Unigene cluster for APOL2 Gene:


mRNA Expression by UniProt/SwissProt for APOL2 Gene:

Tissue specificity: Widely expressed; the highest levels are found in lung, thymus, pancreas, placenta, adult brain and prostate; also detected in spleen, liver, kidney, colon, small intestine, uterus, spinal cord, adrenal gland, salivary gland, trachea, mammary gland, skeletal muscle, testis and fetal brain and liver.

Evidence on tissue expression from TISSUES for APOL2 Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Heart(4.3)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with APOL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOL2 Gene

Orthologs for APOL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia APOL2 34 33
  • 98.62 (n)
(Bos Taurus)
Mammalia APOL3 34 33
  • 66.56 (n)
-- 34
  • 43 (a)
-- 34
  • 35 (a)
(Mus musculus)
Mammalia Apol8 16 33
  • 64.73 (n)
Apol9b 34
  • 41 (a)
Apol9a 34
  • 38 (a)
Apol10b 34
  • 34 (a)
Apol11a 34
  • 34 (a)
Apol10a 34
  • 30 (a)
Apol11b 34
  • 30 (a)
(Rattus norvegicus)
Mammalia LOC100911804 33
  • 64.09 (n)
(Canis familiaris)
Mammalia -- 34
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 28 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 25 (a)
-- 34
  • 22 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
-- 34
  • 32 (a)
(Danio rerio)
Actinopterygii APOL4 34
  • 13 (a)
Species where no ortholog for APOL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOL2 Gene

Gene Tree for APOL2 (if available)
Gene Tree for APOL2 (if available)
Evolutionary constrained regions (ECRs) for APOL2: view image

Paralogs for APOL2 Gene

Paralogs for APOL2 Gene

(5) SIMAP similar genes for APOL2 Gene using alignment to 4 proteins:

  • E9PM95_HUMAN
  • J3KQL8_HUMAN Pseudogenes for APOL2 Gene

genes like me logo Genes that share paralogs with APOL2: view

Variants for APOL2 Gene

Sequence variations from dbSNP and Humsavar for APOL2 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000093192 -- 36,232,581(-) A/G intron_variant
rs1000145457 -- 36,230,496(-) A/G intron_variant
rs1000271114 -- 36,238,514(-) G/A intron_variant
rs1000609678 -- 36,227,887(-) T/C coding_sequence_variant, synonymous_variant
rs1000816631 -- 36,232,921(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for APOL2 Gene

Variant ID Type Subtype PubMed ID
dgv4564n100 CNV gain 25217958
esv1003985 CNV deletion 20482838
esv2760715 CNV gain 21179565
esv3568384 CNV loss 25503493
esv3647680 CNV loss 21293372
esv3647682 CNV gain 21293372
esv3647683 CNV loss 21293372
esv7844 OTHER inversion 19470904
nsv1129335 OTHER inversion 24896259
nsv522931 CNV gain 19592680
nsv834185 CNV loss 17160897

Variation tolerance for APOL2 Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.42; 88.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for APOL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOL2 Gene

Disorders for APOL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for APOL2 Gene - From: OMIM, GTR, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • sczd
phencyclidine abuse
  • pcp abuse
- elite association - COSMIC cancer census association via MalaCards
Search APOL2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for APOL2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with APOL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APOL2 Gene

Publications for APOL2 Gene

  1. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page NM … Lowry PJ (Genomics 2001) 2 3 4 58
  2. Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. (PMID: 11290834) Duchateau PN … Kane JP (Journal of lipid research 2001) 3 4 22 58
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4 58
  4. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 44 58
  5. Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia. (PMID: 18632255) Takahashi S … Tsuang MT (Schizophrenia research 2008) 3 44 58

Products for APOL2 Gene

Sources for APOL2 Gene

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