Aliases for FLRT2 Gene
External Ids for FLRT2 Gene
Previous GeneCards Identifiers for FLRT2 Gene
This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
GeneCards Summary for FLRT2 Gene
FLRT2 (Fibronectin Leucine Rich Transmembrane Protein 2) is a Protein Coding gene. Among its related pathways are Negative regulation of FGFR1 signaling and Signaling by FGFR2. Gene Ontology (GO) annotations related to this gene include protein binding, bridging and chemorepellent activity. An important paralog of this gene is FLRT3.
UniProtKB/Swiss-Prot for FLRT2 Gene
Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.