External Ids for STX12 Gene
Previous GeneCards Identifiers for STX12 Gene
GeneCards Summary for STX12 Gene
STX12 (Syntaxin 12) is a Protein Coding gene. Diseases associated with STX12 include Frontotemporal Dementia. Among its related pathways are Delta508-CFTR traffic / Sorting endosome formation in CF and Delta508-CFTR traffic / ER-to-Golgi in CF. Gene Ontology (GO) annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is STX7.
UniProtKB/Swiss-Prot for STX12 Gene
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).