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Aliases for CCNDBP1 Gene

Aliases for CCNDBP1 Gene

  • Cyclin D1 Binding Protein 1 2 3 5
  • Grap2 And Cyclin-D-Interacting Protein 3 4
  • D-Type Cyclin-Interacting Protein 1 2 3
  • Cyclin D-Type Binding-Protein 1 2 3
  • Human Homolog Of Maid 3 4
  • DIP1 3 4
  • GCIP 3 4
  • HHM 3 4
  • Grap2 And Cyclin D Interacting Protein 2
  • Cyclin-D1-Binding Protein 1 3
  • MAID Protein 2

External Ids for CCNDBP1 Gene

Previous GeneCards Identifiers for CCNDBP1 Gene

  • GC15P038845
  • GC15P036373
  • GC15P041057
  • GC15P041193
  • GC15P041264
  • GC15P043477
  • GC15P020326

Summaries for CCNDBP1 Gene

Entrez Gene Summary for CCNDBP1 Gene

  • This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for CCNDBP1 Gene

CCNDBP1 (Cyclin D1 Binding Protein 1) is a Protein Coding gene. Diseases associated with CCNDBP1 include Optic Disk Drusen and Optic Nerve Disease.

UniProtKB/Swiss-Prot for CCNDBP1 Gene

  • May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.

Gene Wiki entry for CCNDBP1 Gene

Additional gene information for CCNDBP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNDBP1 Gene

Genomics for CCNDBP1 Gene

GeneHancer (GH) Regulatory Elements for CCNDBP1 Gene

Promoters and enhancers for CCNDBP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J043183 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 666 +0.3 259 3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 CCNDBP1 ENSG00000261687 ENSG00000285080 ZSCAN29 CATSPER2P1 CDAN1 ADAL ENSG00000285117 TMEM62
GH15J043230 Enhancer 0.9 ENCODE 29 +45.6 45610 1 HDGF TCF12 ZNF766 GATA2 ZFP91 ATF7 NCOA1 ZNF592 ATF4 GMEB1 CCNDBP1 TGM5 TGM7 EPB42 ENSG00000202211
GH15J043103 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.5 -79.7 -79686 3.4 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 UBR1 CCNDBP1 TTBK2 CDAN1 CATSPER2P1 ZSCAN29 ENSG00000285080 FDPSP4
GH15J043238 Enhancer 0.6 ENCODE 28.7 +53.5 53490 0.7 ZNF687 IKZF1 CREB1 ZBTB33 DPF2 IKZF2 ATF2 EGR2 CCNDBP1 TGM5 ENSG00000202211 EPB42
GH15J043149 Enhancer 0.5 ENCODE 29.1 -34.4 -34398 2.5 JUND USF1 JUN USF2 FOS HOMEZ CCNDBP1 FDPSP10 TMEM62 ENSG00000285080
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNDBP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCNDBP1 gene promoter:
  • NF-kappaB
  • NF-kappaB1
  • STAT5B

Genomic Locations for CCNDBP1 Gene

Genomic Locations for CCNDBP1 Gene
chr15:43,185,118-43,197,177
(GRCh38/hg38)
Size:
12,060 bases
Orientation:
Plus strand
chr15:43,477,316-43,488,229
(GRCh37/hg19)
Size:
10,914 bases
Orientation:
Plus strand

Genomic View for CCNDBP1 Gene

Genes around CCNDBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNDBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNDBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNDBP1 Gene

Proteins for CCNDBP1 Gene

  • Protein details for CCNDBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95273-CCDB1_HUMAN
    Recommended name:
    Cyclin-D1-binding protein 1
    Protein Accession:
    O95273
    Secondary Accessions:
    • A8K3Q0
    • A8K3U2
    • Q6ZQN9
    • Q7Z519
    • Q8NBS7
    • Q8NBY2
    • Q9NS19
    • Q9NYH3
    • Q9UHX9

    Protein attributes for CCNDBP1 Gene

    Size:
    360 amino acids
    Molecular mass:
    40262 Da
    Quaternary structure:
    • Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.
    SequenceCaution:
    • Sequence=AAD11777.1; Type=Frameshift; Positions=8, 14, 18; Evidence={ECO:0000305}; Sequence=AAP97163.1; Type=Frameshift; Positions=17, 40; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CCNDBP1 Gene

    Alternative splice isoforms for CCNDBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNDBP1 Gene

Post-translational modifications for CCNDBP1 Gene

No data available for DME Specific Peptides for CCNDBP1 Gene

Domains & Families for CCNDBP1 Gene

Gene Families for CCNDBP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCNDBP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O95273

UniProtKB/Swiss-Prot:

CCDB1_HUMAN :
  • Belongs to the CCNDBP1 family.
Family:
  • Belongs to the CCNDBP1 family.
genes like me logo Genes that share domains with CCNDBP1: view

Function for CCNDBP1 Gene

Molecular function for CCNDBP1 Gene

UniProtKB/Swiss-Prot Function:
May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.
UniProtKB/Swiss-Prot Induction:
Expression is induced by sodium butyrate, an inhibitor of colon cancer cell proliferation.

Gene Ontology (GO) - Molecular Function for CCNDBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10915743
genes like me logo Genes that share ontologies with CCNDBP1: view
genes like me logo Genes that share phenotypes with CCNDBP1: view

Animal Models for CCNDBP1 Gene

MGI Knock Outs for CCNDBP1:

Animal Model Products

CRISPR Products

miRNA for CCNDBP1 Gene

miRTarBase miRNAs that target CCNDBP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNDBP1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNDBP1 Gene

Localization for CCNDBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNDBP1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNDBP1 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCNDBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12437976
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CCNDBP1: view

Pathways & Interactions for CCNDBP1 Gene

SuperPathways for CCNDBP1 Gene

No Data Available

Pathways by source for CCNDBP1 Gene

1 GeneTex pathway for CCNDBP1 Gene

Gene Ontology (GO) - Biological Process for CCNDBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CCNDBP1: view

No data available for SIGNOR curated interactions for CCNDBP1 Gene

Drugs & Compounds for CCNDBP1 Gene

(1) Additional Compounds for CCNDBP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Na(+)
  • Na+
  • SODIUM ion
7440-23-5
genes like me logo Genes that share compounds with CCNDBP1: view

Transcripts for CCNDBP1 Gene

mRNA/cDNA for CCNDBP1 Gene

Unigene Clusters for CCNDBP1 Gene

Cyclin D-type binding-protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNDBP1

Alternative Splicing Database (ASD) splice patterns (SP) for CCNDBP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - -
SP10: - - -
SP11:
SP12: - - - -
SP13: - - -
SP14:
SP15: - - - -

ExUns: 10a · 10b ^ 11
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CCNDBP1 Gene

GeneLoc Exon Structure for
CCNDBP1
ECgene alternative splicing isoforms for
CCNDBP1

Expression for CCNDBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNDBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNDBP1 Gene

This gene is overexpressed in Whole Blood (x7.1).

Protein differential expression in normal tissues from HIPED for CCNDBP1 Gene

This gene is overexpressed in Adrenal (52.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCNDBP1 Gene



Protein tissue co-expression partners for CCNDBP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCNDBP1 Gene:

CCNDBP1

SOURCE GeneReport for Unigene cluster for CCNDBP1 Gene:

Hs.36794

mRNA Expression by UniProt/SwissProt for CCNDBP1 Gene:

O95273-CCDB1_HUMAN
Tissue specificity: Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.

Evidence on tissue expression from TISSUES for CCNDBP1 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Pancreas(4.2)
  • Eye(2.7)
  • Muscle(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with CCNDBP1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNDBP1 Gene

Orthologs for CCNDBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCNDBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNDBP1 34 33
  • 99.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCNDBP1 34 33
  • 87.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCNDBP1 34 33
  • 86.94 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccndbp1 16 34 33
  • 84.2 (n)
rat
(Rattus norvegicus)
Mammalia Ccndbp1 33
  • 83.96 (n)
oppossum
(Monodelphis domestica)
Mammalia CCNDBP1 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNDBP1 34 33
  • 61.37 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNDBP1 34
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccndbp1 33
  • 58.51 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:162082 33
  • 54.57 (n)
CCNDBP1 34
  • 38 (a)
OneToOne
Species where no ortholog for CCNDBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNDBP1 Gene

ENSEMBL:
Gene Tree for CCNDBP1 (if available)
TreeFam:
Gene Tree for CCNDBP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCNDBP1: view image

Paralogs for CCNDBP1 Gene

No data available for Paralogs for CCNDBP1 Gene

Variants for CCNDBP1 Gene

Sequence variations from dbSNP and Humsavar for CCNDBP1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs201342599 uncertain-significance, Spherocytosis, Recessive 43,197,281(+) A/T downstream_transcript_variant
rs201674874 uncertain-significance, Spherocytosis, Recessive 43,197,346(+) T/C downstream_transcript_variant
rs749454815 uncertain-significance, Spherocytosis, Recessive 43,197,435(+) ATG/ downstream_transcript_variant
rs1000290912 -- 43,195,853(+) T/G 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000395794 -- 43,185,269(+) A/C 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, synonymous_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCNDBP1 Gene

Variant ID Type Subtype PubMed ID
nsv525461 CNV loss 19592680
nsv569241 CNV loss 21841781

Variation tolerance for CCNDBP1 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNDBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNDBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNDBP1 Gene

Disorders for CCNDBP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCNDBP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
optic disk drusen
  • drusen of optic disc
optic nerve disease
  • disorder of the second nerve
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CCNDBP1

genes like me logo Genes that share disorders with CCNDBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNDBP1 Gene

Publications for CCNDBP1 Gene

  1. GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity. (PMID: 10801854) Xia C … Liu M (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells. (PMID: 17621266) Chang TW … Chang MC (Oncogene 2008) 3 4 22 58
  3. GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis. (PMID: 17131381) Ma W … Liu M (Journal of cellular biochemistry 2007) 3 4 22 58
  4. Human GCIP interacts with CT847, a novel Chlamydia trachomatis type III secretion substrate, and is degraded in a tissue-culture infection model. (PMID: 17532760) Chellas-Géry B … Fields KA (Cellular microbiology 2007) 3 22 58
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58

Products for CCNDBP1 Gene

Sources for CCNDBP1 Gene

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