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Aliases for GTPBP4 Gene

Aliases for GTPBP4 Gene

  • GTP Binding Protein 4 2 3 5
  • Chronic Renal Failure Gene Protein 3 4
  • G Protein-Binding Protein CRFG 2 3
  • GTP-Binding Protein NGB 3 4
  • CRFG 3 4
  • NOG1 3 4
  • Nucleolar GTP-Binding Protein 1 3
  • GTP-Binding Protein 2
  • NGB 3

External Ids for GTPBP4 Gene

Previous GeneCards Identifiers for GTPBP4 Gene

  • GC10P001024
  • GC10P000973
  • GC10P001034

Summaries for GTPBP4 Gene

Entrez Gene Summary for GTPBP4 Gene

  • GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTPBP4 Gene

GTPBP4 (GTP Binding Protein 4) is a Protein Coding gene. Diseases associated with GTPBP4 include Commensal Bacterial Infectious Disease. Among its related pathways are Ribosome biogenesis in eukaryotes. Gene Ontology (GO) annotations related to this gene include GTPase activity.

UniProtKB/Swiss-Prot for GTPBP4 Gene

  • Involved in the biogenesis of the 60S ribosomal subunit.

Gene Wiki entry for GTPBP4 Gene

Additional gene information for GTPBP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTPBP4 Gene

Genomics for GTPBP4 Gene

GeneHancer (GH) Regulatory Elements for GTPBP4 Gene

Promoters and enhancers for GTPBP4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J000983 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 664.9 -1.2 -1240 6.8 PKNOX1 CLOCK FOXA2 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 LARP4B GTPBP4 ENSG00000205740 DIP2C ZMYND11 LOC101927762 WDR37 PIR35547
GH10J000929 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 53.4 -57.1 -57090 3.8 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 IRF4 BRCA1 POLR2B ZNF766 LARP4B GTPBP4 ENSG00000205740 LOC101927762 GC10P000921
GH10J001047 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 +61.3 61333 4.3 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 WDR37 IDI1 LARP4B GTPBP4 IDI2-AS1 IDI2
GH10J001054 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 +68.5 68539 4.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B WDR37 IDI1 LARP4B GTPBP4 IDI2 IDI2-AS1
GH10J000509 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -477.1 -477051 1.9 PKNOX1 ARID4B SIN3A ZNF2 ZNF48 SLC30A9 ZNF143 NFYC REST NFIL3 GTPBP4 DIP2C ZMYND11 PIR53292 ENSG00000233021
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTPBP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GTPBP4 gene promoter:
  • POU2F1a
  • POU2F1
  • GATA-1
  • IRF-2
  • Ik-3
  • STAT1
  • STAT1alpha
  • STAT1beta
  • deltaCREB
  • CREB

Genomic Locations for GTPBP4 Gene

Genomic Locations for GTPBP4 Gene
31,918 bases
Plus strand
31,539 bases
Plus strand

Genomic View for GTPBP4 Gene

Genes around GTPBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTPBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTPBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTPBP4 Gene

Proteins for GTPBP4 Gene

  • Protein details for GTPBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar GTP-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KMC5
    • B4DY13
    • B7Z7A3
    • O95446
    • Q5T3R8
    • Q9NVJ8

    Protein attributes for GTPBP4 Gene

    634 amino acids
    Molecular mass:
    73964 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GTPBP4 Gene


neXtProt entry for GTPBP4 Gene

Post-translational modifications for GTPBP4 Gene

  • Ubiquitination at isoforms=2, 3181, Lys145, isoforms=2118, isoforms=2103, and Lys25
  • Modification sites at PhosphoSitePlus

Other Protein References for GTPBP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GTPBP4 Gene

Domains & Families for GTPBP4 Gene

Gene Families for GTPBP4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
genes like me logo Genes that share domains with GTPBP4: view

Function for GTPBP4 Gene

Molecular function for GTPBP4 Gene

UniProtKB/Swiss-Prot Function:
Involved in the biogenesis of the 60S ribosomal subunit.

Gene Ontology (GO) - Molecular Function for GTPBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0003924 GTPase activity IDA 17210637
GO:0005515 protein binding IPI 17210637
GO:0005525 GTP binding IDA 17210637
genes like me logo Genes that share ontologies with GTPBP4: view
genes like me logo Genes that share phenotypes with GTPBP4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTPBP4 Gene

Localization for GTPBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTPBP4 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTPBP4 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
plasma membrane 3
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GTPBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17210637
GO:0005730 nucleolus IEA,IDA --
GO:0005737 cytoplasm IDA 17210637
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with GTPBP4: view

Pathways & Interactions for GTPBP4 Gene

genes like me logo Genes that share pathways with GTPBP4: view

Pathways by source for GTPBP4 Gene

1 KEGG pathway for GTPBP4 Gene

Gene Ontology (GO) - Biological Process for GTPBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IDA 17210637
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA --
GO:0001649 osteoblast differentiation HDA 16210410
GO:0008156 negative regulation of DNA replication IMP 17210637
GO:0008285 negative regulation of cell proliferation IMP 17210637
genes like me logo Genes that share ontologies with GTPBP4: view

No data available for SIGNOR curated interactions for GTPBP4 Gene

Drugs & Compounds for GTPBP4 Gene

(1) Drugs for GTPBP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GTPBP4: view

Transcripts for GTPBP4 Gene

mRNA/cDNA for GTPBP4 Gene

Unigene Clusters for GTPBP4 Gene

GTP binding protein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTPBP4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b
SP1: - - - - -
SP2: - - - -
SP4: -

Relevant External Links for GTPBP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GTPBP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GTPBP4 Gene

Protein differential expression in normal tissues from HIPED for GTPBP4 Gene

This gene is overexpressed in Lung (19.0), Breast (8.9), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTPBP4 Gene

Protein tissue co-expression partners for GTPBP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GTPBP4 Gene:


SOURCE GeneReport for Unigene cluster for GTPBP4 Gene:


Evidence on tissue expression from TISSUES for GTPBP4 Gene

  • Kidney(4.5)
  • Nervous system(4.5)
  • Muscle(2.8)
  • Adrenal gland(2.6)
  • Heart(2.6)
  • Liver(2.5)
  • Blood(2.4)
  • Eye(2.3)
  • Lung(2.1)
  • Skin(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with GTPBP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTPBP4 Gene

Orthologs for GTPBP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GTPBP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GTPBP4 34 33
  • 95.92 (n)
(Monodelphis domestica)
Mammalia GTPBP4 34
  • 90 (a)
(Mus musculus)
Mammalia Gtpbp4 16 34 33
  • 88.96 (n)
(Rattus norvegicus)
Mammalia Gtpbp4 33
  • 88.17 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 87 (a)
-- 34
  • 83 (a)
(Canis familiaris)
Mammalia GTPBP4 34 33
  • 86.41 (n)
(Bos Taurus)
Mammalia GTPBP4 34 33
  • 86.01 (n)
(Gallus gallus)
Aves GTPBP4 34 33
  • 78.55 (n)
(Anolis carolinensis)
Reptilia GTPBP4 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gtpbp4 33
  • 74.3 (n)
Str.2929 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24805 33
(Danio rerio)
Actinopterygii gtpbp4 34 33
  • 72.05 (n)
wufi28d07 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007050 33
  • 58.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8801 34 33
  • 58.76 (n)
(Caenorhabditis elegans)
Secernentea T07A9.9 34 33
  • 58.4 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR194W 33
  • 54.31 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24135g 33
  • 53.61 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOG1 36 34 33
  • 52.52 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G10300 33
  • 56.52 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5831 33
(Oryza sativa)
Liliopsida Os07g0110200 33
  • 52.35 (n)
Os.14676 33
(Hordeum vulgare)
Liliopsida Hv.4238 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3484 34
  • 63 (a)
Cin.9 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nog1 33
  • 54.85 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05289 33
  • 52.71 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9 33
Species where no ortholog for GTPBP4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTPBP4 Gene

Gene Tree for GTPBP4 (if available)
Gene Tree for GTPBP4 (if available)
Evolutionary constrained regions (ECRs) for GTPBP4: view image

Paralogs for GTPBP4 Gene

No data available for Paralogs for GTPBP4 Gene

Variants for GTPBP4 Gene

Sequence variations from dbSNP and Humsavar for GTPBP4 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000009560 -- 1,002,184(+) G/T intron_variant
rs1000057898 -- 993,665(+) G/A intron_variant
rs1000206510 -- 1,009,370(+) A/G intron_variant
rs1000240402 -- 987,970(+) C/A/T upstream_transcript_variant
rs1000290729 -- 999,386(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GTPBP4 Gene

Variant ID Type Subtype PubMed ID
dgv74e201 CNV deletion 23290073
esv1067888 CNV deletion 17803354
esv1468754 CNV insertion 17803354
esv1989555 CNV deletion 18987734
esv24871 CNV gain 19812545
esv2551854 CNV insertion 19546169
esv2660097 CNV deletion 23128226
esv2729239 CNV deletion 23290073
esv2729251 CNV deletion 23290073
esv2729262 CNV deletion 23290073
esv2729273 CNV deletion 23290073
esv2729284 CNV deletion 23290073
esv2729295 CNV deletion 23290073
esv2729306 CNV deletion 23290073
esv2729328 CNV deletion 23290073
esv2729339 CNV deletion 23290073
esv3545708 CNV deletion 23714750
esv3891735 CNV gain 25118596
nsv1068262 CNV deletion 25765185
nsv1124337 CNV deletion 24896259
nsv1125172 CNV insertion 24896259
nsv1133144 CNV tandem duplication 24896259
nsv1137365 CNV deletion 24896259
nsv1137862 CNV deletion 24896259
nsv1150353 CNV deletion 26484159
nsv1161921 CNV duplication 26073780
nsv549765 CNV gain 21841781

Variation tolerance for GTPBP4 Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTPBP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTPBP4 Gene

Disorders for GTPBP4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GTPBP4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
commensal bacterial infectious disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GTPBP4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GTPBP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTPBP4 Gene

Publications for GTPBP4 Gene

  1. Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease. (PMID: 11316846) Laping NJ … Zhu Y (Journal of the American Society of Nephrology : JASN 2001) 2 3 4 58
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for GTPBP4 Gene

Sources for GTPBP4 Gene

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