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Aliases for ZNF281 Gene

Aliases for ZNF281 Gene

  • Zinc Finger Protein 281 2 3 3 5
  • GC-Box-Binding Zinc Finger Protein 1 3 4
  • Zinc Finger DNA-Binding Protein 99 3 4
  • Transcription Factor ZBP-99 3 4
  • ZNP-99 Transcription Factor 3
  • ZBP-99 3
  • ZNP-99 3
  • ZBP99 4
  • GZP1 4

External Ids for ZNF281 Gene

Previous GeneCards Identifiers for ZNF281 Gene

  • GC01M198105
  • GC01M195834
  • GC01M196842
  • GC01M197664
  • GC01M197663
  • GC01M197107
  • GC01M198642
  • GC01M200375
  • GC01M171541

Summaries for ZNF281 Gene

GeneCards Summary for ZNF281 Gene

ZNF281 (Zinc Finger Protein 281) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ZNF148.

UniProtKB/Swiss-Prot for ZNF281 Gene

  • Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.

Gene Wiki entry for ZNF281 Gene

Additional gene information for ZNF281 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF281 Gene

Genomics for ZNF281 Gene

GeneHancer (GH) Regulatory Elements for ZNF281 Gene

Promoters and enhancers for ZNF281 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J200408 Promoter/Enhancer 2.6 UCNEbase EPDnew Ensembl ENCODE 650.7 -0.7 -660 4.3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B PIR39640 ZNF281 GC01M200475 ENSG00000230623
GH01J200351 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 39.1 +56.3 56306 4.9 IRF2 PKNOX1 EBF1 BATF IRF4 GATA3 POLR2A EED FOS ETV6 ZNF281 LINC00862 ENSG00000230623 DDX59 GC01P200359 GC01P200337
GH01J200361 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 35.5 +45.6 45597 5.1 CTCF BACH1 YY1 ZNF316 POLR2A FOSL2 NFE2 MAFK ZBTB20 NFE2L2 ZNF281 ENSG00000230623 TMEM9 GC01P200359 GC01M200383 LINC00862
GH01J200371 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.5 +35.7 35705 6.7 FOXA2 MLX ARID4B NEUROD1 SIN3A FEZF1 DMAP1 YY1 FOS SP3 ZNF281 ENSG00000230623 GC01M200383 GC01P200359 LINC00862
GH01J200378 Enhancer 1.3 Ensembl ENCODE dbSUPER 13.3 +29.7 29742 3.4 FOXA2 SIN3A BMI1 BRCA1 RARA RFX5 YY1 ATF7 RCOR1 FOS ZNF281 GC01M200383 LINC00862 GC01P200359 ENSG00000230623
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF281 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF281 gene promoter:
  • Nkx2-5
  • Lmo2
  • Pax-4a
  • c-Myc
  • Max1
  • FOXJ2
  • FOXJ2 (long isoform)
  • STAT5A
  • C/EBPalpha

Genomic Locations for ZNF281 Gene

Genomic Locations for ZNF281 Gene
chr1:200,404,940-200,410,058
(GRCh38/hg38)
Size:
5,119 bases
Orientation:
Minus strand
chr1:200,374,068-200,379,184
(GRCh37/hg19)
Size:
5,117 bases
Orientation:
Minus strand

Genomic View for ZNF281 Gene

Genes around ZNF281 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF281 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF281 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF281 Gene

Proteins for ZNF281 Gene

  • Protein details for ZNF281 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2X9-ZN281_HUMAN
    Recommended name:
    Zinc finger protein 281
    Protein Accession:
    Q9Y2X9
    Secondary Accessions:
    • A6NF48
    • B3KMX2
    • Q5RKW5
    • Q9NY92

    Protein attributes for ZNF281 Gene

    Size:
    895 amino acids
    Molecular mass:
    96915 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB70967.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF281 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF281 Gene

Post-translational modifications for ZNF281 Gene

  • Ubiquitination at isoforms=2840, posLast=661661, and isoforms=2539
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF281 Gene

No data available for DME Specific Peptides for ZNF281 Gene

Domains & Families for ZNF281 Gene

Gene Families for ZNF281 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF281 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF281 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2X9

UniProtKB/Swiss-Prot:

ZN281_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF281: view

Function for ZNF281 Gene

Molecular function for ZNF281 Gene

UniProtKB/Swiss-Prot Function:
Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.
GENATLAS Biochemistry:
zinc finger protein 281,regulating ornithine decarboxylase gene (ODC) expression,major transcript,highly expressed in placenta,adult kidney,liver,lymphocytes,binding to thhe GC rich promoter element of gastrin and ODC

Phenotypes From GWAS Catalog for ZNF281 Gene

Gene Ontology (GO) - Molecular Function for ZNF281 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10448078
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001047 core promoter binding ISS --
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10448078
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF281: view
genes like me logo Genes that share phenotypes with ZNF281: view

Animal Models for ZNF281 Gene

MGI Knock Outs for ZNF281:

Animal Model Products

CRISPR Products

miRNA for ZNF281 Gene

miRTarBase miRNAs that target ZNF281

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF281

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF281 Gene

Localization for ZNF281 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF281 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF281 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF281 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10448078
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF281: view

Pathways & Interactions for ZNF281 Gene

genes like me logo Genes that share pathways with ZNF281: view

Pathways by source for ZNF281 Gene

2 BioSystems pathways for ZNF281 Gene

Gene Ontology (GO) - Biological Process for ZNF281 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 10448078
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010172 embryonic body morphogenesis ISS --
GO:0010629 negative regulation of gene expression IMP 10448078
genes like me logo Genes that share ontologies with ZNF281: view

No data available for SIGNOR curated interactions for ZNF281 Gene

Drugs & Compounds for ZNF281 Gene

No Compound Related Data Available

Transcripts for ZNF281 Gene

mRNA/cDNA for ZNF281 Gene

Unigene Clusters for ZNF281 Gene

Zinc finger protein 281:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF281

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF281 Gene

No ASD Table

Relevant External Links for ZNF281 Gene

GeneLoc Exon Structure for
ZNF281
ECgene alternative splicing isoforms for
ZNF281

Expression for ZNF281 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF281 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF281 Gene

This gene is overexpressed in Brain (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF281 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF281 Gene:

ZNF281

SOURCE GeneReport for Unigene cluster for ZNF281 Gene:

Hs.59757

Evidence on tissue expression from TISSUES for ZNF281 Gene

  • Liver(4.3)
  • Skin(4.2)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with ZNF281: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF281 Gene

Orthologs for ZNF281 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF281 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF281 34 33
  • 99.77 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp281 16 34 33
  • 94.35 (n)
rat
(Rattus norvegicus)
Mammalia Zfp281 33
  • 93.61 (n)
dog
(Canis familiaris)
Mammalia ZNF281 33
  • 91.45 (n)
cow
(Bos Taurus)
Mammalia ZNF281 34 33
  • 89.09 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF281 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF281 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF281 34 33
  • 83.11 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF281 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf281 33
  • 67.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30049 33
zebrafish
(Danio rerio)
Actinopterygii LOC100005963 33
  • 57.59 (n)
ZNF281 (2 of 2) 34
  • 39 (a)
OneToMany
ZNF281 (1 of 2) 34
  • 36 (a)
OneToMany
Species where no ortholog for ZNF281 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF281 Gene

ENSEMBL:
Gene Tree for ZNF281 (if available)
TreeFam:
Gene Tree for ZNF281 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF281: view image

Paralogs for ZNF281 Gene

Paralogs for ZNF281 Gene

genes like me logo Genes that share paralogs with ZNF281: view

Variants for ZNF281 Gene

Sequence variations from dbSNP and Humsavar for ZNF281 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035576 A breast cancer sample p.Ile527Thr
rs1000008332 -- 200,451,629(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000071037 -- 200,451,704(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000141925 -- 200,428,322(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000200390 -- 200,445,536(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF281 Gene

Variant ID Type Subtype PubMed ID
nsv548990 CNV loss 21841781

Variation tolerance for ZNF281 Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF281 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF281

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF281 Gene

Disorders for ZNF281 Gene

Additional Disease Information for ZNF281

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF281 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF281 Gene

Publications for ZNF281 Gene

  1. ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression. (PMID: 10448078) Law DJ … Merchant JL (Biochemical and biophysical research communications 1999) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1. (PMID: 12771217) Zhang X … Zehner ZE (Nucleic acids research 2003) 3 4 58
  5. Identification of human GC-box-binding zinc finger protein, a new Krüppel-like zinc finger protein, by the yeast one-hybrid screening with a GC-rich target sequence. (PMID: 10405178) Lisowsky T … Cantatore P (FEBS letters 1999) 3 4 58

Products for ZNF281 Gene

Sources for ZNF281 Gene

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