Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ACAP2 Gene

Aliases for ACAP2 Gene

  • ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 2 2 3 5
  • Centaurin-Beta-2 3 4
  • CNT-B2 3 4
  • CENTB2 3 4
  • Arf-GAP With Coiled-Coil, ANK Repeat And PH Domain-Containing Protein 2 3
  • Arf GAP With Coiled Coil, ANK Repeat And PH Domains 2 3
  • Centaurin, Beta 2 2
  • KIAA0041 4

External Ids for ACAP2 Gene

Previous HGNC Symbols for ACAP2 Gene

  • CENTB2

Previous GeneCards Identifiers for ACAP2 Gene

  • GC03M196477
  • GC03M194995
  • GC03M192371

Summaries for ACAP2 Gene

GeneCards Summary for ACAP2 Gene

ACAP2 (ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 2) is a Protein Coding gene. Among its related pathways are Endocytosis and Arf6 signaling events. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rab GTPase binding. An important paralog of this gene is ACAP3.

UniProtKB/Swiss-Prot for ACAP2 Gene

  • GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).

Gene Wiki entry for ACAP2 Gene

Additional gene information for ACAP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACAP2 Gene

Genomics for ACAP2 Gene

GeneHancer (GH) Regulatory Elements for ACAP2 Gene

Promoters and enhancers for ACAP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I195440 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.0 1016 3.8 HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A DMAP1 YY1 SLC30A9 ZNF207 ACAP2 LSG1 XXYLT1 SDHAP2 SDHAP1 ENSG00000207368 GC03M195420
GH03I196078 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 39.9 -637.8 -637806 4.4 MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 MEF2D GLIS1 RCOR2 TFRC SDHAP1 SDHAP2 LINC00969 UBXN7 ACAP2 ENSG00000230732 RNU6ATAC24P MUC4 SENP5
GH03I196163 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 26.7 -721.5 -721463 2.9 HDGF ARNT ZNF493 ARID4B YBX1 DMAP1 ZNF2 TCF12 SLC30A9 POLR2B SDHAP1 SDHAP2 LINC00969 UBXN7 RNU6ATAC24P ACAP2 ENSG00000230732 RNF168 UBXN7-AS1 GC03P196177
GH03I196337 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.6 -896.2 -896224 4.4 HDGF PKNOX1 ARNT SIN3A YY1 POLR2B ZNF766 E2F8 FOS SMARCB1 TM4SF19 TM4SF19-TCTEX1D2 SDHAP1 LINC00969 UBXN7 SDHAP2 ENSG00000230732 ACAP2 ENSG00000260261 ENSG00000231443
GH03I195697 Enhancer 1.1 Ensembl ENCODE 29.8 -255.2 -255160 1.8 HDGF HNRNPUL1 PKNOX1 ATF1 ARNT YBX1 POLR2B E2F8 ARID2 FOS GC03P195715 GC03P195716 MIR570 PIR60122 PIR60219 SDHAP1 SDHAP2 UBXN7 ACAP2 LINC00969
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ACAP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACAP2 gene promoter:

Genomic Locations for ACAP2 Gene

Genomic Locations for ACAP2 Gene
chr3:195,274,736-195,443,176
(GRCh38/hg38)
Size:
168,441 bases
Orientation:
Minus strand
chr3:194,995,465-195,163,817
(GRCh37/hg19)

Genomic View for ACAP2 Gene

Genes around ACAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACAP2 Gene

Proteins for ACAP2 Gene

  • Protein details for ACAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15057-ACAP2_HUMAN
    Recommended name:
    Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
    Protein Accession:
    Q15057
    Secondary Accessions:
    • A8K2V4
    • Q8N5Z8
    • Q9UQR3

    Protein attributes for ACAP2 Gene

    Size:
    778 amino acids
    Molecular mass:
    88029 Da
    Quaternary structure:
    • Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits ACAP2 to membranes. Interacts with MICALL1; the interaction is indirect through RAB35 (By similarity).
    SequenceCaution:
    • Sequence=BAA05064.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB41450.1; Type=Frameshift; Positions=98, 106, 111; Evidence={ECO:0000305};

neXtProt entry for ACAP2 Gene

Post-translational modifications for ACAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ACAP2 Gene

Domains & Families for ACAP2 Gene

Suggested Antigen Peptide Sequences for ACAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ACAP2: view

No data available for UniProtKB/Swiss-Prot for ACAP2 Gene

Function for ACAP2 Gene

Molecular function for ACAP2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).

Phenotypes From GWAS Catalog for ACAP2 Gene

Gene Ontology (GO) - Molecular Function for ACAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0017137 Rab GTPase binding IEA --
GO:0046872 metal ion binding IEA --
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding IEA --
genes like me logo Genes that share ontologies with ACAP2: view
genes like me logo Genes that share phenotypes with ACAP2: view

miRNA for ACAP2 Gene

miRTarBase miRNAs that target ACAP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACAP2 Gene

Localization for ACAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACAP2 Gene

Endosome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACAP2 gene
Compartment Confidence
endosome 5
plasma membrane 3
nucleus 3
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ACAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0010008 endosome membrane ISS --
GO:0016020 membrane HDA,IEA 19946888
genes like me logo Genes that share ontologies with ACAP2: view

Pathways & Interactions for ACAP2 Gene

SuperPathways for ACAP2 Gene

SuperPathway Contained pathways
1 Endocytosis
2 Arf6 signaling events
genes like me logo Genes that share pathways with ACAP2: view

Pathways by source for ACAP2 Gene

1 BioSystems pathway for ACAP2 Gene
1 KEGG pathway for ACAP2 Gene

Gene Ontology (GO) - Biological Process for ACAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036010 protein localization to endosome ISS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:1990090 cellular response to nerve growth factor stimulus ISS --
genes like me logo Genes that share ontologies with ACAP2: view

No data available for SIGNOR curated interactions for ACAP2 Gene

Drugs & Compounds for ACAP2 Gene

(12) Additional Compounds for ACAP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with ACAP2: view

Transcripts for ACAP2 Gene

Unigene Clusters for ACAP2 Gene

ArfGAP with coiled-coil, ankyrin repeat and PH domains 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACAP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2:
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6:
SP7: - -
SP8: - - - -
SP9:
SP10:
SP11:
SP12: -

ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ACAP2 Gene

GeneLoc Exon Structure for
ACAP2
ECgene alternative splicing isoforms for
ACAP2

Expression for ACAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACAP2 Gene

mRNA differential expression in normal tissues according to GTEx for ACAP2 Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for ACAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.0) and Lymph node (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACAP2 Gene



Protein tissue co-expression partners for ACAP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACAP2 Gene:

ACAP2

SOURCE GeneReport for Unigene cluster for ACAP2 Gene:

Hs.593373

mRNA Expression by UniProt/SwissProt for ACAP2 Gene:

Q15057-ACAP2_HUMAN
Tissue specificity: Widely expressed. Highest level in lung.

Evidence on tissue expression from TISSUES for ACAP2 Gene

  • Nervous system(4.6)
  • Blood(4.3)
  • Bone marrow(4.2)
  • Liver(4.2)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with ACAP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACAP2 Gene

Orthologs for ACAP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACAP2 33 34
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia ACAP2 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACAP2 33 34
  • 92.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ACAP2 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acap2 33 16 34
  • 89.31 (n)
rat
(Rattus norvegicus)
Mammalia Acap2 33
  • 89.26 (n)
oppossum
(Monodelphis domestica)
Mammalia ACAP2 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACAP2 34 33
  • 80.22 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 8 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia acap2 33
  • 75.66 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68712 33
zebrafish
(Danio rerio)
Actinopterygii acap2 34
  • 70 (a)
OneToMany
ACAP2 (1 of 2) 34
  • 65 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2620 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000563 33
  • 49.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta cenB1A 33 34
  • 48.08 (n)
worm
(Caenorhabditis elegans)
Secernentea cnt-1 33 34
  • 46.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE1 34
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AGD2 33
  • 47.08 (n)
rice
(Oryza sativa)
Liliopsida Os02g0632500 33
  • 47.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToMany
Species where no ortholog for ACAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACAP2 Gene

ENSEMBL:
Gene Tree for ACAP2 (if available)
TreeFam:
Gene Tree for ACAP2 (if available)

Paralogs for ACAP2 Gene

Paralogs for ACAP2 Gene

(3) SIMAP similar genes for ACAP2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ACAP2: view

Variants for ACAP2 Gene

Sequence variations from dbSNP and Humsavar for ACAP2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000009344 -- 195,313,803(-) T/C intron_variant
rs1000029154 -- 195,428,561(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000043543 -- 195,429,877(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000080714 -- 195,419,301(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000083922 -- 195,393,052(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ACAP2 Gene

Variant ID Type Subtype PubMed ID
esv2657233 CNV deletion 23128226
esv2662107 CNV deletion 23128226
esv2669458 CNV deletion 23128226
esv2726463 CNV deletion 23290073
esv2759213 CNV gain+loss 17122850
esv3304862 CNV mobile element insertion 20981092
esv3324582 CNV insertion 20981092
esv3599226 CNV gain 21293372
esv3599234 CNV loss 21293372
esv8403 CNV gain 19470904
nsv1006229 CNV gain 25217958
nsv1009796 CNV gain 25217958
nsv508977 CNV insertion 20534489
nsv526569 CNV gain 19592680
nsv829824 CNV loss 17160897
nsv963394 CNV duplication 23825009

Variation tolerance for ACAP2 Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACAP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACAP2 Gene

Disorders for ACAP2 Gene

Additional Disease Information for ACAP2

No disorders were found for ACAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACAP2 Gene

Publications for ACAP2 Gene

  1. ACAPs are arf6 GTPase-activating proteins that function in the cell periphery. (PMID: 11062263) Jackson TR … Randazzo PA (The Journal of cell biology 2000) 2 3 4 22 58
  2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling. (PMID: 11050434) Jackson TR … Theibert AB (Trends in biochemical sciences 2000) 2 3 58
  5. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. (PMID: 11001876) Dowler S … Alessi DR (The Biochemical journal 2000) 3 22 58

Products for ACAP2 Gene

Sources for ACAP2 Gene

Content
Loading form....