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Aliases for SRRM2 Gene

Aliases for SRRM2 Gene

  • Serine/Arginine Repetitive Matrix 2 2 3 5
  • Serine/Arginine-Rich Splicing Factor-Related Nuclear Matrix Protein Of 300 KDa 3 4
  • Tax-Responsive Enhancer Element-Binding Protein 803 3 4
  • Ser/Arg-Related Nuclear Matrix Protein Of 300 KDa 3 4
  • SR-Related Nuclear Matrix Protein Of 300 KDa 3 4
  • Splicing Coactivator Subunit SRm300 3 4
  • 300 KDa Nuclear Matrix Antigen 3 4
  • TaxREB803 3 4
  • SRL300 3 4
  • Serine/Arginine Repetitive Matrix Protein 2 3
  • Testicular Secretory Protein Li 53 3
  • RNA Binding Protein 3
  • KIAA0324 4
  • HSPC075 3
  • 300-KD 3
  • SRm300 3
  • SRM300 4
  • CWF21 3
  • Cwc21 3

External Ids for SRRM2 Gene

Previous GeneCards Identifiers for SRRM2 Gene

  • GC16P002822
  • GC16P002802
  • GC16P002742
  • GC16P002769
  • GC16P002754
  • GC16P002756
  • GC16P002762
  • GC16P002835
  • GC16P002891
  • GC16P002928
  • GC16P002970

Summaries for SRRM2 Gene

GeneCards Summary for SRRM2 Gene

SRRM2 (Serine/Arginine Repetitive Matrix 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include C2H2 zinc finger domain binding. An important paralog of this gene is SRRM3.

UniProtKB/Swiss-Prot for SRRM2 Gene

  • Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA.

Gene Wiki entry for SRRM2 Gene

Additional gene information for SRRM2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRM2 Gene

Genomics for SRRM2 Gene

GeneHancer (GH) Regulatory Elements for SRRM2 Gene

Promoters and enhancers for SRRM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J002750 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 682.9 +0.7 743 4.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 SRRM2 SRRM2-AS1 GC16P003532 ZNF75A ZNF263 TSC2 ERVK13-1 ZNF213-AS1 E4F1 ENSG00000261938
GH16J002481 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 650.1 -268.9 -268871 4.1 PKNOX1 FOXA2 ARID4B SLC30A9 NFKBIZ RXRA SP5 MXD4 REST ZNF592 GC16P002483 SRRM2 TBC1D24 ENSG00000260293 ENSG00000260272
GH16J002147 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 75.6 -596.5 -596539 17.4 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 TRAF7 SNORD60 SNHG19 GC16M002158 GC16M002156 ENSG00000281010 RAB26 ENSG00000261505 CRAMP1 ENSG00000260051
GH16J003019 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 86.4 +270.0 269974 5.2 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC THOC6 TNFRSF12A HCFC1R1 ZNF263 ENSG00000261938 SRRM2 E4F1 CREBBP TSC2 ERVK13-1
GH16J001962 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 58.7 -788.1 -788107 4.1 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ENSG00000255513 SNORA64 SNHG9 RPS2 GC16M001963 GC16M001965 GC16M001966 GC16P002236 SNORA78 GC16M001962
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRRM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SRRM2 gene promoter:
  • p53
  • Olf-1
  • MyoD
  • PPAR-alpha
  • AP-2alpha isoform 3
  • Brachyury
  • Pax-4a
  • AP-2alpha
  • AP-2alpha isoform 2

Regulatory Element Products

Genomic Locations for SRRM2 Gene

Genomic Locations for SRRM2 Gene
chr16:2,752,329-2,772,538
(GRCh38/hg38)
Size:
20,210 bases
Orientation:
Plus strand
chr16:2,802,330-2,822,539
(GRCh37/hg19)
Size:
20,210 bases
Orientation:
Plus strand

Genomic View for SRRM2 Gene

Genes around SRRM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRRM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRRM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRM2 Gene

Proteins for SRRM2 Gene

  • Protein details for SRRM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ35-SRRM2_HUMAN
    Recommended name:
    Serine/arginine repetitive matrix protein 2
    Protein Accession:
    Q9UQ35
    Secondary Accessions:
    • A6NKB9
    • D3DU97
    • O15038
    • O94803
    • Q6NSL3
    • Q6PIM3
    • Q6PK40
    • Q8IW17
    • Q96GY7
    • Q9P0G1
    • Q9UHA8
    • Q9UQ36
    • Q9UQ37
    • Q9UQ38
    • Q9UQ40

    Protein attributes for SRRM2 Gene

    Size:
    2752 amino acids
    Molecular mass:
    299615 Da
    Quaternary structure:
    • Component of the active spliceosome. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2. Identified in the spliceosome C complex.
    Miscellaneous:
    • Can functionally substitute for CWC12 in yeast.
    SequenceCaution:
    • Sequence=AAF21439.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF28898.1; Type=Frameshift; Positions=167, 175, 179; Evidence={ECO:0000305}; Sequence=AAH70050.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA20782.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SRRM2 Gene

    Alternative splice isoforms for SRRM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRRM2 Gene

Post-translational modifications for SRRM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SRRM2 Gene

Domains & Families for SRRM2 Gene

Gene Families for SRRM2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SRRM2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UQ35

UniProtKB/Swiss-Prot:

SRRM2_HUMAN :
  • Belongs to the CWC21 family.
Family:
  • Belongs to the CWC21 family.
genes like me logo Genes that share domains with SRRM2: view

Function for SRRM2 Gene

Molecular function for SRRM2 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA.

Phenotypes From GWAS Catalog for SRRM2 Gene

Gene Ontology (GO) - Molecular Function for SRRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0005515 protein binding IPI 15324660
GO:0047485 protein N-terminus binding IPI 17577209
GO:0070742 C2H2 zinc finger domain binding IDA 17577209
genes like me logo Genes that share ontologies with SRRM2: view
genes like me logo Genes that share phenotypes with SRRM2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRRM2 Gene

Localization for SRRM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRRM2 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRRM2 gene
Compartment Confidence
nucleus 5
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 28076346
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0015030 Cajal body IDA 17577209
GO:0016607 nuclear speck IEA,IDA 17577209
genes like me logo Genes that share ontologies with SRRM2: view

Pathways & Interactions for SRRM2 Gene

genes like me logo Genes that share pathways with SRRM2: view

Pathways by source for SRRM2 Gene

Gene Ontology (GO) - Biological Process for SRRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SRRM2: view

No data available for SIGNOR curated interactions for SRRM2 Gene

Drugs & Compounds for SRRM2 Gene

No Compound Related Data Available

Transcripts for SRRM2 Gene

mRNA/cDNA for SRRM2 Gene

Unigene Clusters for SRRM2 Gene

Serine/arginine repetitive matrix 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRRM2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^
SP1: - -
SP2:
SP3: - -
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14: - - - -
SP15:
SP16: -
SP17:
SP18:

ExUns: 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2: - - - -
SP3:
SP4:
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - - - - - - - - -
SP17:
SP18: -

Relevant External Links for SRRM2 Gene

GeneLoc Exon Structure for
SRRM2
ECgene alternative splicing isoforms for
SRRM2

Expression for SRRM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRRM2 Gene

Protein differential expression in normal tissues from HIPED for SRRM2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRRM2 Gene



Protein tissue co-expression partners for SRRM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRRM2 Gene:

SRRM2

SOURCE GeneReport for Unigene cluster for SRRM2 Gene:

Hs.433343

mRNA Expression by UniProt/SwissProt for SRRM2 Gene:

Q9UQ35-SRRM2_HUMAN
Tissue specificity: Expressed in liver, placenta, and white blood cells.

Evidence on tissue expression from TISSUES for SRRM2 Gene

  • Nervous system(5)
  • Blood(4.8)
  • Intestine(4.7)
  • Liver(4.6)
  • Lung(4.6)
  • Muscle(4.6)
  • Eye(4.5)
  • Kidney(3.6)
  • Skin(3)
  • Thyroid gland(2.9)
  • Heart(2.7)
  • Bone marrow(2.4)
  • Spleen(2.4)
  • Stomach(2.4)
  • Lymph node(2.3)
  • Gall bladder(2.2)
  • Adrenal gland(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with SRRM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRRM2 Gene

Orthologs for SRRM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRRM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRRM2 34 33
  • 99.39 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SRRM2 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srrm2 34
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRRM2 34 33
  • 79.82 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRRM2 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRRM2 34
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRRM2 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10856 33
zebrafish
(Danio rerio)
Actinopterygii srrm2 34
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7971 34
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsr-2 34
  • 32 (a)
OneToMany
Species where no ortholog for SRRM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRRM2 Gene

ENSEMBL:
Gene Tree for SRRM2 (if available)
TreeFam:
Gene Tree for SRRM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRRM2: view image

Paralogs for SRRM2 Gene

Paralogs for SRRM2 Gene

(2) SIMAP similar genes for SRRM2 Gene using alignment to 12 proteins:

  • SRRM2_HUMAN
  • A0AUK8_HUMAN
  • I3L0N7_HUMAN
  • I3L182_HUMAN
  • I3L1C0_HUMAN
  • I3L1I8_HUMAN
  • I3L1W5_HUMAN
  • I3L3Q8_HUMAN
  • I3L4D8_HUMAN
  • I3L4U6_HUMAN
  • Q05BI2_HUMAN
  • Q05CV9_HUMAN
genes like me logo Genes that share paralogs with SRRM2: view

Variants for SRRM2 Gene

Sequence variations from dbSNP and Humsavar for SRRM2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000029672 -- 2,753,336(+) C/T genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000103778 -- 2,756,369(+) ACAACGG/ coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, stop_gained
rs1000177608 -- 2,769,008(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000219278 -- 2,756,221(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000287967 -- 2,764,782(+) A/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SRRM2 Gene

Variant ID Type Subtype PubMed ID
esv2760067 CNV gain+loss 17122850
nsv471073 CNV loss 18288195
nsv827522 CNV gain 20364138
nsv833123 CNV gain+loss 17160897

Variation tolerance for SRRM2 Gene

Residual Variation Intolerance Score: 1.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.82; 86.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRRM2 Gene

Human Gene Mutation Database (HGMD)
SRRM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRRM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRM2 Gene

Disorders for SRRM2 Gene

Additional Disease Information for SRRM2

No disorders were found for SRRM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRRM2 Gene

Publications for SRRM2 Gene

  1. Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains. (PMID: 11004489) Sawada Y … Ohtaki S (Biochimica et biophysica acta 2000) 2 3 4 58
  2. The SRm160/300 splicing coactivator subunits. (PMID: 10668804) Blencowe BJ … Sharp PA (RNA (New York, N.Y.) 2000) 2 3 4 58
  3. A coactivator of pre-mRNA splicing. (PMID: 9531537) Blencowe BJ … Sharp PA (Genes & development 1998) 3 4 22 58
  4. SRRM2, a potential blood biomarker revealing high alternative splicing in Parkinson's disease. (PMID: 20161708) Shehadeh LA … Papapetropoulos S (PloS one 2010) 3 22 58
  5. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C … Mann M (Science (New York, N.Y.) 2009) 3 4 58

Products for SRRM2 Gene

Sources for SRRM2 Gene

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