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Aliases for ANP32D Gene

Aliases for ANP32D Gene

  • Acidic Nuclear Phosphoprotein 32 Family Member D 2 3 5
  • Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member D 2 3
  • Phosphoprotein 32-Related Protein 2 3 4
  • Tumorigenic Protein Pp32r2 3 4
  • Pp32 Related 2 2 3
  • PP32R2 3 4
  • Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member D 3
  • Acidic Nuclear Phosphoprotein 32D 3

External Ids for ANP32D Gene

Previous GeneCards Identifiers for ANP32D Gene

  • GC12P048832
  • GC12P048765
  • GC12P048583
  • GC12P047152
  • GC12P045900
  • GC12P048866

Summaries for ANP32D Gene

Entrez Gene Summary for ANP32D Gene

  • Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANP32D Gene

ANP32D (Acidic Nuclear Phosphoprotein 32 Family Member D) is a Protein Coding gene. Diseases associated with ANP32D include Chronic Mountain Sickness. An important paralog of this gene is ANP32A.

Gene Wiki entry for ANP32D Gene

Additional gene information for ANP32D Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANP32D Gene

Genomics for ANP32D Gene

GeneHancer (GH) Regulatory Elements for ANP32D Gene

Promoters and enhancers for ANP32D Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J048409 Enhancer 0.7 ENCODE 10.4 -62.6 -62638 0.8 HDAC1 MEIS2 KLF1 LEF1 PKNOX1 ATF1 RB1 E4F1 CTBP1 MTA3 C12orf54 ANP32D OR8S21P OR5BJ1P ENSG00000257735 GC12M048339
GH12J048482 Promoter 0.5 EPDnew 0.4 +9.8 9814 0.1 C12orf54 RPS10P20 ANP32D GC12M048339
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANP32D on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANP32D gene promoter:
  • Nkx6-1
  • CUTL1
  • IRF-7A
  • HNF-3beta
  • GATA-2
  • ZID
  • S8
  • Nkx2-5
  • NF-1
  • Sox9

Genomic Locations for ANP32D Gene

Genomic Locations for ANP32D Gene
960 bases
Plus strand
396 bases
Plus strand

Genomic View for ANP32D Gene

Genes around ANP32D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANP32D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANP32D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANP32D Gene

Proteins for ANP32D Gene

  • Protein details for ANP32D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acidic leucine-rich nuclear phosphoprotein 32 family member D
    Protein Accession:
    Secondary Accessions:
    • Q6NTC4

    Protein attributes for ANP32D Gene

    131 amino acids
    Molecular mass:
    14806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANP32D Gene

Post-translational modifications for ANP32D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANP32D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANP32D Gene

Domains & Families for ANP32D Gene

Gene Families for ANP32D Gene

Protein Domains for ANP32D Gene


Suggested Antigen Peptide Sequences for ANP32D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ANP32 family.
  • Belongs to the ANP32 family.
genes like me logo Genes that share domains with ANP32D: view

Function for ANP32D Gene

Phenotypes From GWAS Catalog for ANP32D Gene

Gene Ontology (GO) - Molecular Function for ANP32D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042393 histone binding IBA --
genes like me logo Genes that share ontologies with ANP32D: view
genes like me logo Genes that share phenotypes with ANP32D: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANP32D Gene

Localization for ANP32D Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANP32D gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Centrosome (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANP32D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0048471 perinuclear region of cytoplasm IBA --
genes like me logo Genes that share ontologies with ANP32D: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANP32D Gene

Pathways & Interactions for ANP32D Gene

SuperPathways for ANP32D Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANP32D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 NOT nucleosome assembly IBA --
GO:0006338 chromatin remodeling IBA --
GO:0006913 nucleocytoplasmic transport IBA --
GO:0042981 regulation of apoptotic process IBA --
GO:0043486 NOT histone exchange IBA --
genes like me logo Genes that share ontologies with ANP32D: view

No data available for Pathways by source and SIGNOR curated interactions for ANP32D Gene

Drugs & Compounds for ANP32D Gene

No Compound Related Data Available

Transcripts for ANP32D Gene

mRNA/cDNA for ANP32D Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANP32D Gene

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member D:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANP32D Gene

No ASD Table

Relevant External Links for ANP32D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANP32D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANP32D Gene

NURSA nuclear receptor signaling pathways regulating expression of ANP32D Gene:


SOURCE GeneReport for Unigene cluster for ANP32D Gene:

genes like me logo Genes that share expression patterns with ANP32D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANP32D Gene

Orthologs for ANP32D Gene

This gene was present in the common ancestor of animals.

Orthologs for ANP32D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 77 (a)
(Mus musculus)
Mammalia Anp32a 34
  • 45 (a)
(Bos Taurus)
Mammalia ANP32A 34
  • 45 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 39 (a)
(Canis familiaris)
Mammalia -- 34
  • 35 (a)
(Gallus gallus)
Aves -- 34
  • 39 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 42 (a)
(Danio rerio)
Actinopterygii anp32a 34
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mapmodulin 34
  • 18 (a)
(Caenorhabditis elegans)
Secernentea F33H2.3 34
  • 21 (a)
T19H12.2 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11188 34
  • 23 (a)
Species where no ortholog for ANP32D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ANP32D Gene

Gene Tree for ANP32D (if available)
Gene Tree for ANP32D (if available)
Evolutionary constrained regions (ECRs) for ANP32D: view image

Paralogs for ANP32D Gene

Paralogs for ANP32D Gene

(4) SIMAP similar genes for ANP32D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANP32D: view

Variants for ANP32D Gene

Sequence variations from dbSNP and Humsavar for ANP32D Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000812574 -- 48,472,235(+) C/T upstream_transcript_variant
rs1001719432 -- 48,473,422(+) A/C downstream_transcript_variant
rs1005573238 -- 48,472,530(+) G/T upstream_transcript_variant
rs1009653769 -- 48,471,840(+) C/T upstream_transcript_variant
rs1010069395 -- 48,472,564(+) C/A upstream_transcript_variant

Variation tolerance for ANP32D Gene

Residual Variation Intolerance Score: 69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANP32D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANP32D Gene

Disorders for ANP32D Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANP32D Gene - From: GeneCards

Disorder Aliases PubMed IDs
chronic mountain sickness
  • chronic mountain sickness, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANP32D

genes like me logo Genes that share disorders with ANP32D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANP32D Gene

Publications for ANP32D Gene

  1. Modulation of oncogenic potential by alternative gene use in human prostate cancer. (PMID: 10086381) Kadkol SS … Pasternack GR (Nature medicine 1999) 2 3 4 22 58
  2. The Anp32 family of proteins containing leucine-rich repeats. (PMID: 15895553) Matilla A … Radrizzani M (Cerebellum (London, England) 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Identification of sequences required for inhibition of oncogene-mediated transformation by pp32. (PMID: 10400610) Brody JR … Pasternack GR (The Journal of biological chemistry 1999) 2 3 58
  5. Correction to "Modulation of oncogenic potential by alternative gene use in human prostate cancer" (PMID: 10471270) Kadkol SS … Pasternack GR (Nature medicine 1999) 3 4 58

Products for ANP32D Gene

Sources for ANP32D Gene

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