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Aliases for SEC61G Gene

Aliases for SEC61G Gene

  • Sec61 Translocon Gamma Subunit 2 3 5
  • Sec61 Gamma Subunit 2 3
  • Protein Transport Protein SEC61 Gamma Subunit 3
  • Protein Transport Protein Sec61 Subunit Gamma 3
  • SSS1 3

External Ids for SEC61G Gene

Previous GeneCards Identifiers for SEC61G Gene

  • GC07M054284
  • GC07M054527
  • GC07M054561
  • GC07M054594
  • GC07M054787

Summaries for SEC61G Gene

Entrez Gene Summary for SEC61G Gene

  • The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC61G Gene

SEC61G (Sec61 Translocon Gamma Subunit) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include protein transporter activity and P-P-bond-hydrolysis-driven protein transmembrane transporter activity.

UniProtKB/Swiss-Prot for SEC61G Gene

  • Necessary for protein translocation in the endoplasmic reticulum.

Gene Wiki entry for SEC61G Gene

Additional gene information for SEC61G Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC61G Gene

Genomics for SEC61G Gene

GeneHancer (GH) Regulatory Elements for SEC61G Gene

Promoters and enhancers for SEC61G Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J054757 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 700.3 +1.0 982 2.9 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF143 FOS SEC61G LOC100996654 GC07P054734
GH07J054773 Enhancer 1 Ensembl ENCODE 49.9 -14.3 -14260 1.4 ELF3 ATF1 RB1 ARID4B SIN3A ZNF2 ZNF48 ZBTB40 ZSCAN9 RAD21 SEC61G LOC100996654 GC07P054734 GC07P054865
GH07J054809 Enhancer 0.7 Ensembl ENCODE 37.3 -51.3 -51349 2.7 JUND POLR2A JUNB CEBPB EP300 ATF2 RUNX3 SEC61G LOC100996654 GC07P054865
GH07J055253 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 10.6 -495.0 -495004 2.3 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF48 GLIS2 ZNF207 ZNF143 ATF7 ELDR PIR38213 LOC100130121 LOC100996654 SEC61G EGFR GC07P055243
GH07J054813 Enhancer 0.4 ENCODE 36.1 -53.6 -53649 0.2 YY1 GABPA SEC61G LOC100996654 GC07P054865
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEC61G on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEC61G gene promoter:
  • Elk-1
  • Evi-1
  • Max
  • c-Myc
  • TBP
  • XBP-1
  • Egr-2
  • IRF-1
  • Egr-4

Genomic Locations for SEC61G Gene

Genomic Locations for SEC61G Gene
7,728 bases
Minus strand
7,728 bases
Minus strand

Genomic View for SEC61G Gene

Genes around SEC61G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC61G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC61G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC61G Gene

Proteins for SEC61G Gene

  • Protein details for SEC61G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein transport protein Sec61 subunit gamma
    Protein Accession:
    Secondary Accessions:
    • B2R4J0
    • P38384
    • Q6IB25

    Protein attributes for SEC61G Gene

    68 amino acids
    Molecular mass:
    7741 Da
    Quaternary structure:
    • Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

neXtProt entry for SEC61G Gene

Post-translational modifications for SEC61G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEC61G Gene

No data available for DME Specific Peptides for SEC61G Gene

Domains & Families for SEC61G Gene

Gene Families for SEC61G Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SEC61G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SecE/SEC61-gamma family.
  • Belongs to the SecE/SEC61-gamma family.
genes like me logo Genes that share domains with SEC61G: view

Function for SEC61G Gene

Molecular function for SEC61G Gene

UniProtKB/Swiss-Prot Function:
Necessary for protein translocation in the endoplasmic reticulum.

Phenotypes From GWAS Catalog for SEC61G Gene

Gene Ontology (GO) - Molecular Function for SEC61G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008565 protein transporter activity ISS --
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SEC61G: view
genes like me logo Genes that share phenotypes with SEC61G: view

Animal Model Products

CRISPR Products

miRNA for SEC61G Gene

miRTarBase miRNAs that target SEC61G

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEC61G

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC61G Gene

Localization for SEC61G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC61G Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC61G gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
nucleus 2
golgi apparatus 1
plasma membrane 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SEC61G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 22375059
genes like me logo Genes that share ontologies with SEC61G: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SEC61G Gene

Pathways & Interactions for SEC61G Gene

genes like me logo Genes that share pathways with SEC61G: view

Gene Ontology (GO) - Biological Process for SEC61G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0036498 IRE1-mediated unfolded protein response TAS --
GO:0045047 protein targeting to ER ISS --
genes like me logo Genes that share ontologies with SEC61G: view

No data available for SIGNOR curated interactions for SEC61G Gene

Drugs & Compounds for SEC61G Gene

No Compound Related Data Available

Transcripts for SEC61G Gene

mRNA/cDNA for SEC61G Gene

Unigene Clusters for SEC61G Gene

Sec61 gamma subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEC61G

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC61G Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - -
SP2: -
SP3: -
SP4: -
SP5: -

Relevant External Links for SEC61G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC61G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC61G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC61G Gene

This gene is overexpressed in Bone (16.0) and Hair follicle (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SEC61G Gene

Protein tissue co-expression partners for SEC61G Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SEC61G Gene:


SOURCE GeneReport for Unigene cluster for SEC61G Gene:


Evidence on tissue expression from TISSUES for SEC61G Gene

  • Lung(4.4)
  • Nervous system(4.4)
  • Skin(4.3)
  • Blood(4.2)
  • Adrenal gland(2)
  • Intestine(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with SEC61G: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC61G Gene

Orthologs for SEC61G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC61G Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia SEC61G 34
  • 100 (a)
(Pan troglodytes)
Mammalia SEC61G 34 33
  • 100 (n)
(Ornithorhynchus anatinus)
Mammalia SEC61G 34
  • 100 (a)
(Canis familiaris)
Mammalia SEC61G 34 33
  • 96.57 (n)
(Bos Taurus)
Mammalia SEC61G 34 33
  • 96.57 (n)
(Mus musculus)
Mammalia LOC102637269 33
  • 92.65 (n)
Sec61g 16 34
  • 68 (a)
(Rattus norvegicus)
Mammalia LOC499136 33
  • 88.89 (n)
(Gallus gallus)
Aves SEC61G 34 33
  • 88.73 (n)
(Anolis carolinensis)
Reptilia SEC61G 34
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec61g 33
  • 82.35 (n)
African clawed frog
(Xenopus laevis)
Amphibia sec61g-A 33
(Danio rerio)
Actinopterygii sec61g 34 33
  • 82.35 (n)
hmzehn1231 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10075 33
fruit fly
(Drosophila melanogaster)
Insecta Sec61gamma 34
  • 81 (a)
CG8860 34 33
  • 70.15 (n)
CG13426 34
  • 35 (a)
(Caenorhabditis elegans)
Secernentea emo-1 34 33
  • 74.51 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSS1 34
  • 38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24920 33
  • 65.69 (n)
(Oryza sativa)
Liliopsida Os02g0178400 33
  • 59.31 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3850 34
  • 87 (a)
Cin.15317 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15317 33
Species where no ortholog for SEC61G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC61G Gene

Gene Tree for SEC61G (if available)
Gene Tree for SEC61G (if available)
Evolutionary constrained regions (ECRs) for SEC61G: view image

Paralogs for SEC61G Gene

No data available for Paralogs for SEC61G Gene

Variants for SEC61G Gene

Sequence variations from dbSNP and Humsavar for SEC61G Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000155095 -- 54,756,566(-) T/C intron_variant
rs1000943817 -- 54,756,740(-) T/G intron_variant
rs1001203345 -- 54,759,404(-) T/C upstream_transcript_variant
rs1001376226 -- 54,756,957(-) AC/ intron_variant
rs1001700578 -- 54,754,002(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SEC61G Gene

Variant ID Type Subtype PubMed ID
esv2734425 CNV deletion 23290073
esv2761332 CNV gain 21179565
nsv1024361 CNV gain 25217958
nsv1030676 CNV gain 25217958
nsv607029 CNV gain 21841781

Variation tolerance for SEC61G Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC61G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC61G Gene

Disorders for SEC61G Gene

Additional Disease Information for SEC61G

No disorders were found for SEC61G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC61G Gene

Publications for SEC61G Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58
  3. The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. (PMID: 10212142) Greenfield JJ … High S (Journal of cell science 1999) 2 3 58
  4. Evolutionary conservation of components of the protein translocation complex. (PMID: 8107851) Hartmann E … Rapoport TA (Nature 1994) 2 3 58
  5. Novel SEC61G-EGFR Fusion Gene in Pediatric Ependymomas Discovered by Clonal Expansion of Stem Cells in Absence of Exogenous Mitogens. (PMID: 29092923) Servidei T … Riccardi R (Cancer research 2017) 3 58

Products for SEC61G Gene

Sources for SEC61G Gene

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